Evidence for local production of antibodies to auto and non-self antigens in periodontal disease.

abstract：OBJECTIVE:To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes. METHOD:Inhibitor studies on cultured keratinocytes and Western blot analysis. RESULTS:Blocking of MMP-9 activity strongly reduces shedding of Dsg3 from cell surface. MMP-2 has a less releva...

journal_title：Oral diseases

authors： Cirillo N,Femiano F,Gombos F,Lanza A

更新日期：2007-05-01 00:00:00

abstract：:Over the last thirty years, the human immunodeficiency virus (HIV) epidemic has matured. In the United States, HIV has changed from an explosive outbreak to an endemic disease; currently, an estimated 1.1 million people are infected with HIV, including a substantial number who are unaware of their status. With recent ...

journal_title：Oral diseases

authors： Wilson E,Tanzosh T,Maldarelli F

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVES:We examined the content of YouTube(™) videos on mouth (oral) cancer and evaluated their usefulness in promoting early detection of oral cancer. MATERIALS AND METHODS:A systematic search of YouTube(™) for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral ...

journal_title：Oral diseases

authors： Hassona Y,Taimeh D,Marahleh A,Scully C

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insi...

journal_title：Oral diseases

authors： Rahajoe PS,Smit MJ,Kertia N,Westra J,Vissink A

更新日期：2019-09-01 00:00:00

abstract：:The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugars in caries. In ...

journal_title：Oral diseases

authors： Giacaman RA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to investigate the cysteine protease inhibitory properties of the human salivary cystatins S, SA and SN in order to identify potential in vivo target cysteine proteases which may include those involved in periodontal tissue destruction. In addition, the potential role of the salivar...

journal_title：Oral diseases

authors： Baron A,DeCarlo A,Featherstone J

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels o...

journal_title：Oral diseases

authors： Jakovljevic A,Knezevic A,Nikolic N,Soldatovic I,Jovanovic T,Milasin J,Andric M

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Orofacial clefts (OFCs) are common and etiologically complex birth defects. This study explored potential genetic differences in a pair of Japanese monozygotic (MZ) twins with different forms of OFC using whole-genome sequencing. SUBJECTS AND METHODS:One co-twin (MZ-1) presented with nonsyndromic bilateral c...

journal_title：Oral diseases

authors： Takahashi M,Hosomichi K,Yamaguchi T,Nagahama R,Yoshida H,Maki K,Marazita ML,Weinberg SM,Tajima A

更新日期：2018-10-01 00:00:00

abstract：:Well into the fourth decade of the HIV/AIDS pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. Prominent among these is oral hairy leukoplakia...

journal_title：Oral diseases

authors： Greenspan JS,Greenspan D,Webster-Cyriaque J

更新日期：2016-04-01 00:00:00

abstract：AIM:To investigate prospectively the qualitative and quantitative changes in oral carriage of yeasts and coliforms in southern Chinese people suffering from stroke. MATERIALS AND METHODS:In 56 elderly people suffering from stroke in a rehabilitation unit of a general medical hospital in Hong Kong, oral microbiological...

journal_title：Oral diseases

authors： Zhu HW,McMillan AS,McGrath C,Li LS,Samaranayake LP

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro. MATERIALS AND METHODS:Ninety-six dentin samples were prepared from 24 freshl...

journal_title：Oral diseases

authors： Meyer-Lueckel H,Schulte-Mönting J,Kielbassa AM

更新日期：2002-07-01 00:00:00

abstract：:Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...

journal_title：Oral diseases

authors： Gaurilcikaite E,Renton T,Grant AD

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity. MATERIALS AND METHODS:The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, including immunohistochemist...

journal_title：Oral diseases

authors： Sun ZJ,Zhang L,Zhang WF,Chen XM,Lai FM,Zhao YF

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo-controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP. DESIGN:The degree of lesio...

journal_title：Oral diseases

authors： Petruzzi M,De Benedittis M,Grassi R,Cassano N,Vena G,Serpico R

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:Periodontal and cardiovascular diseases share some common underlying mechanisms. Hyperlipidemia is a major risk factor for cardiovascular diseases. This study sought to assess the association of hyperlipidemia and statin consumption with periodontal status. MATERIALS AND METHODS:This cross-sectional study w...

journal_title：Oral diseases

authors： Sayar F,Fallah S,Akhondi N,Jamshidi S

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:In this study, we aimed to clarify the precise mechanism underlying lipopolysaccharide (LPS)-induced osteoclastogenesis in periodontal disease with a special reference to double-stranded RNA-dependent protein kinase (PKR). MATERIAL AND METHODS:We dissected the role of PKR in LPS-induced osteoclast differenti...

journal_title：Oral diseases

authors： Teramachi J,Inagaki Y,Shinohara H,Okamura H,Yang D,Ochiai K,Baba R,Morimoto H,Nagata T,Haneji T

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:Increasing evidence indicates that andrographolide (ADG) exhibits anti-cancer activity against various cancer cell lines. However, its high hydrophobicity and poor bioavailability restrict its clinical application as a chemopreventative agent. Previously, we have shown that ADG-loaded solid lipid nanoparticl...

journal_title：Oral diseases

authors： Li H,Qu X,Qian W,Song Y,Wang C,Liu W

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVES AND DESIGN:A preceding paper has noted a detection of defensin-1 (HNP-1), a peptide with antimicrobial and cytotoxic properties, in the saliva of patients with oral squamous cell carcinoma. The present study deals with the presence of HNP-1 in the saliva of patients with various oral diseases. METHODS:Whole...

journal_title：Oral diseases

authors： Mizukawa N,Sugiyama K,Ueno T,Mishima K,Takagi S,Sugahara T

更新日期：1999-04-01 00:00:00

abstract：:Hyaline ring granuloma (HRG) is a rare and atypical foreign-body granulomatous chronic inflammatory condition. Our aim was to make a critical review of the literature cases and also to illustrate histochemical and immunohistochemical findings of a new case. A modified PICO strategy was used. Inclusion criteria were me...

journal_title：Oral diseases

authors： Kimura TC,Carneiro MC,Coelho YFS,de Sousa SCOM,Veltrini VC

更新日期：2020-01-24 00:00:00

abstract：BACKGROUND:Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. METHODS:Databases including Ovid MEDLINE, ...

journal_title：Oral diseases

authors： Wahab A,Onkamo O,Pirinen M,Almangush A,Salo T

更新日期：2020-10-08 00:00:00

abstract：OBJECTIVE:To assess changes in the salivary expression of IL-1α, IL-1β, IL-2, IL-6, IL-10, IL-17, and TNF in acute leukemia (AL) patients before and during chemotherapy, and its association with HSV infection, oral candidiasis (OC), and oral mucositis (OM) onset. METHODS:Cohort study in AL patients >15 years starting ...

journal_title：Oral diseases

authors： Ramírez-Amador V,Zambrano JG,Anaya-Saavedra G,Zentella-Dehesa A,Irigoyen-Camacho E,Meráz-Cruz N,Ponce de León-Rosales S

更新日期：2017-10-01 00:00:00

abstract：AIM:The objective of this study was to investigate the effects of bisphosphonate on the mandible of rats in the growing phase with steroid-induced osteoporosis, and to estimate the biomechanical response in the mandibular bone. MATERIALS AND METHODS:Eight-week-old male Wistar rats (n = 50) were assigned to a 6-week co...

journal_title：Oral diseases

authors： Kimura E,Nishioka T,Hasegawa K,Maki K

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVES:To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from 131 I therapy in differentiated thyroid cancer patients. METHODS:Differentiated thyroid cancer patients who were clinically scheduled for an 131 I therapy at ...

journal_title：Oral diseases

authors： Wu D,Khorjekar G,Kharazi P,Moreau S,Kulkarni K,Burman KD,Wartofsky L,Van Nostrand D

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Inflammatory papillary hyperplasia of the palate (IPHP) or the granular type of denture stomatitis, is a non-neoplastic lesion characterized histologically by a significant epithelial hyperplasia and inflammatory infiltrate usually caused by trauma and Candida infection. p53 and proliferative cell nuclear ant...

journal_title：Oral diseases

authors： Kaplan I,Vered M,Moskona D,Buchner A,Dayan D

更新日期：1998-09-01 00:00:00

abstract：:Candidosis is by far the commonest oral fungal infection in man and could manifest as an adverse effect of drug therapy such as inhaled or topically applied corticosteroids. Due to the anti-inflammatory and immunosuppressive effect steroids are used in the management of bronchial asthma and oral mucosal diseases. In t...

journal_title：Oral diseases

authors： Ellepola AN,Samaranayake LP

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVES:This systematic review was to evaluate the change of oral microbiome based on next-generation sequencing (NGS)-metagenomic analysis following periodontal interventions among systematically healthy subjects. MATERIALS AND METHODS:A structured search strategy consisting of "metagenomics" and "oral diseases" w...

journal_title：Oral diseases

authors： Zhang Y,Qi Y,Lo ECM,McGrath C,Mei ML,Dai R

更新日期：2020-05-11 00:00:00

abstract：:The aim of this article is to review the clinical, pathophysiological, and therapeutic aspects of traumatically induced trigeminal nerve pain. We introduce a new and, in our view, more accurate terminology: peripheral painful traumatic trigeminal neuropathy (PPTTN) to define this patient group. The proposed pathophysi...

journal_title：Oral diseases

authors： Benoliel R,Kahn J,Eliav E

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS. METHODS:Eighte...

journal_title：Oral diseases

authors： Treldal C,Jacobsen CB,Mogensen S,Rasmussen M,Jacobsen J,Petersen J,Lynge Pedersen AM,Andersen O

更新日期：2016-03-01 00:00:00

abstract：:The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...

journal_title：Oral diseases

authors： van der Meulen TA,Harmsen H,Bootsma H,Spijkervet F,Kroese F,Vissink A

更新日期：2016-11-01 00:00:00

abstract：:This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...

journal_title：Oral diseases

authors： Thornhill MH,Li J

更新日期：1997-03-01 00:00:00