Abstract:
:The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such as microbial antigens and metabolites. In systemic autoimmune diseases (SADs) such as rheumatoid arthritis, systemic lupus erythematosus and Sjögren's syndrome, the immune system is deranged to a chronic inflammatory state and autoantibodies are an important hallmark. Specific bacteria and/or a dysbiosis in the human microbiome can lead to local mucosal inflammation and increased intestinal permeability. Proinflammatory lymphocytes and cytokines can spread to the systemic circulation and increase the risk of inflammation at distant anatomical sites, such as the joints or salivary glands. Increased intestinal permeability increases antigen exposure and the risk of autoantibody production. If the human microbiome indeed plays such a critical role in SADs, this finding holds a great promise for new therapeutic strategies, such as diet interventions and probiotics and prebiotics. This review provides a background on the human microbiome and mucosal immunity in the gut and oral cavity and gives a summary of the current knowledge on the microbiome-SADs connection.
journal_name
Oral Disjournal_title
Oral diseasesauthors
van der Meulen TA,Harmsen H,Bootsma H,Spijkervet F,Kroese F,Vissink Adoi
10.1111/odi.12472subject
Has Abstractpub_date
2016-11-01 00:00:00pages
719-734issue
8eissn
1354-523Xissn
1601-0825journal_volume
22pub_type
杂志文章,评审相关文献
ORAL DISEASES文献大全abstract::The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12763
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVE:To obtain baseline information on the prevalence of oral problems and disease in institutionalized elderly in a Scottish hospital. DESIGN:A cross-sectional clinical investigation with complementary microbiological studies as appropriate. SUBJECTS AND METHODS:A cohort of 147 elderly in five long-term care wa...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1995.tb00177.x
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:The purposes of this study were to assess the influence of age on oral squamous cell carcinoma patients and sought to analyze the reasons that may contribute to this difference. METHODS:This study enrolled 2,782 patients included 2,443 patients in a retrospective cohort to find the influence of age and 339 ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13015
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus. Therefore, we developed novel species-specific oligonucleotide probes to accurately speciate seven pathogenic...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.02926.x
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVES:Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS:Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg k...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12513
更新日期:2016-10-01 00:00:00
abstract:UNLABELLED:Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 at the 1p36 region and p63 at the 3q27-29 region, have recently been identified. They share considerable sequence homolog...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.02920.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:The early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG + CD). SUBJECT...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13537
更新日期:2021-03-01 00:00:00
abstract:OBJECTIVES:The association between body mass index (BMI) and oral diseases was investigated, and levels of obesity-related inflammatory mediators were evaluated. SUBJECTS AND METHODS:Participants (n = 160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponec...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12679
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:To compare the diagnostic accuracy of 18 F-FDG PET/CT and conventional contrast-enhanced CT for the re-staging of recurrent salivary gland carcinoma (SGC). MATERIALS AND METHODS:This study included 58 consecutive patients who underwent recurrent SGCs after definitive treatment. The recurrences were evaluated...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12877
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01407.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies ag...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12127
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the antitumor effects of fusion protein hGrB-TV of human granzyme B (hGrB) and truncated vascular endothelial growth factor (tVEGF) on human oral squamous cell carcinoma (OSCC) in vitro and in vivo. METHODS:The fusion protein hGrB-TV was expressed and purified from E. coli bacteria by affinity ch...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12522
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To establish whether an intra-oral lubricating device for dry mouth alters the oral environment. DESIGN:A single-blind randomized cross-over study. METHOD:Twenty-nine dentate subjects from the Sjogren's syndrome clinic attended on five occasions at 4-week intervals. They were randomized, having the device f...
journal_title:Oral diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2005.01161.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. The current study a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12124
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to examine the relationship between active osteoclasts, as defined by positive nuclear NFATc1 signals, and the clinical behaviors of oral giant cell granulomas. MATERIALS AND METHODS:NFATc1 immunohistochemical and TRAP-Cbfa1 double immunofluorescence stainings were performed on 9 ca...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13022
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus pr...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01612.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in healthy controls towards stimulation to Porphyromonas gingivalis (Pg) and Actinobacillus actinomyce...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01323.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT). PATIENTS AND METHODS:The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treat...
journal_title:Oral diseases
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1601-0825.1997.tb00049.x
更新日期:1997-12-01 00:00:00
abstract:OBJECTIVES:A multicentre collaborative study by the London HIV and Dentistry Group failed to associate the presence of erythematous candidiasis (EC) with advanced HIV disease. Data from a study of the periodontal health of homosexual men attending a genito-urinary medicine clinic presented an opportunity to investigate...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00339.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:Cyclosporine A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of gingival overgrowth. Type I plasminogen activator inhibitor (PAI-1) has shown to play an important role in CsA-induced gingival overgrowth. However, little is known about whether factors can modulate ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01653.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the oral functionality and the oral sensorimotor alterations are associated with oropharyngeal dysphagia in community-dwelling older persons and long-term care older residents. METHODS:An exploratory study with 265 independent older persons of the southern state of Brazil. The diagnosis o...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12809
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:We aimed to investigate BRAF V600E percentage immunohistochemically in ameloblastomas of a single institute cohort. We were interested if age, location, histological properties, or tumor recurrence depend on the BRAF status. SUBJECTS, MATERIALS AND METHODS:We had 36 formalin-fixed, paraffin-embedded amelobl...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13072
更新日期:2019-05-01 00:00:00
abstract::Well into the fourth decade of the HIV/AIDS pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. Prominent among these is oral hairy leukoplakia...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12393
更新日期:2016-04-01 00:00:00
abstract::Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13704
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVES:This systematic review was to evaluate the change of oral microbiome based on next-generation sequencing (NGS)-metagenomic analysis following periodontal interventions among systematically healthy subjects. MATERIALS AND METHODS:A structured search strategy consisting of "metagenomics" and "oral diseases" w...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13405
更新日期:2020-05-11 00:00:00
abstract::Elder neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandato...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12797
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of EBV-DNA, CMV-DNA and HPV-DNA in oral healthy mucosa of HIV-infected and renal transplant patients. To associate the detection of viral genomes with laboratory parameters of immunodeficiency, gender, antiretroviral and immunosuppressive therapy. DESIGN:A cross-sectional analysi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study. MATERIALS AND METHODS:Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13552
更新日期:2020-07-23 00:00:00
abstract:OBJECTIVE:To investigate the therapeutic effect of oral glucosamine (GS) as an adjunct to hyaluronic acid (HA) injection on patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS:In this clinical trial, 136 participants, diagnosed as TMJ OA clinically and radiographically, were enrolled and randomized ...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/odi.12760
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12990
更新日期:2019-03-01 00:00:00