Abstract:
OBJECTIVES:The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus presence within these cysts. MATERIALS AND METHODS:Samples of 10 odontogenic keratocysts (five positive and five negative for the presence of cytomegalovirus, as determined by polymerase chain reaction) and 10 periapical cysts (five positive and five negative for the cytomegalovirus presence) were analysed. The expression of survivin was assessed by immunohistochemical methods, using monoclonal antibody that selectively recognizes the cytoplasmic form of survivin. RESULTS:All 10 odontogenic keratocysts showed immunostaining for survivin, while all 10 periapical cysts were negative for its presence. There was no correlation between cytomegalovirus presence and expression of survivin within odontogenic keratocysts. CONCLUSION:Survivin may contribute to the aggressive behavior of odontogenic keratocysts, and thus support the emerging opinion of their neoplastic nature.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Andric M,Dozic B,Popovic B,Stefanovic D,Basta-Jovanovic G,Djogo N,Andjus P,Milasin Jdoi
10.1111/j.1601-0825.2009.01612.xsubject
Has Abstractpub_date
2010-03-01 00:00:00pages
156-9issue
2eissn
1354-523Xissn
1601-0825pii
ODI1612journal_volume
16pub_type
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