Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice.

Abstract:

INTRODUCTION:Clastic cells, originating from the monocyte-macrophage lineage, resorb mineralized tissues. In periapical periodontitis, alveolar bone around the tooth apex becomes resorbed; however, the roots of the teeth are often left intact by yet unknown mechanisms. Here, we examined the status of clastic cells in a periapical periodontitis model in mice. METHODS:Periapical periodontitis was induced by performing pulp exposure on the maxillary first molar. The contralateral maxillary first molar was used as a control. The maxillae were harvested, fixed, and subjected to μCT scanning and three-dimensional volumetric analysis. TRAP staining was performed, and osteoclasts were quantified. Immunohistochemical staining was performed for RANKL, OPG, and F4/80, a marker for macrophages. RESULTS:At the apex of the tooth, pulp exposure resulted in periapical radiolucency with mineralized tissues at the surrounding bone surfaces but not on the root surfaces. Histologically, clastic cells were present on the bone surfaces but absent around the root surfaces. Expression of F4/80 and RANKL was not found at close proximity to the root surfaces, but OPG was globally expressed. CONCLUSION:The absence of clastic cells around the root surface of pulp-exposed teeth, in part, is associated with the lack of macrophages and RANKL expression.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Shah A,Lee D,Song M,Kim S,Kang MK,Kim RH

doi

10.1111/odi.12824

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

57-62

issue

1-2

eissn

1354-523X

issn

1601-0825

journal_volume

24

pub_type

杂志文章
  • Clinical and genetic analysis of patients with cherubism.

    abstract:OBJECTIVE:To describe the clinical and genetic features of patients with cherubism. MATERIAL AND METHODS:A descriptive analysis of 14 cases from nine different families was carried out. Clinicopathological, imaging, and follow-up data were retrieved from patients' medical files and correlated with the genetic profile ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12705

    authors: Machado RA,Pontes H,Pires FR,Silveira HM,Bufalino A,Carlos R,Tuji FM,Alves D,Santos-Silva AR,Lopes MA,Capistrano HM,Coletta RD,Fonseca FP

    更新日期:2017-11-01 00:00:00

  • Oral lichen planus: a preliminary clinical study on treatment with tazarotene.

    abstract:OBJECTIVE:The rationale for using tazarotene in oral lichen planus (OLP) is its regulatory action on the growth and differentiation of keratinocytes and on inflammation. This randomized, placebo-controlled study addresses evaluation of the effects of topic tazarotene in the treatment of OLP. DESIGN:The degree of lesio...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1034/j.1601-0825.2002.02833.x

    authors: Petruzzi M,De Benedittis M,Grassi R,Cassano N,Vena G,Serpico R

    更新日期:2002-11-01 00:00:00

  • Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway.

    abstract:OBJECTIVES:Toll-like receptor 4 (TLR4) is abnormally expressed in oral cancer tissues and promotes cancer cell invasion. The purpose of this study was to clarify the mechanism by which autophagy regulates oral cancer invasion through the TLR4-NF-κB pathway. SUBJECTS AND METHODS:We examined TLR4 expression in oral canc...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13355

    authors: Kong Q,Liang Y,He Q,You Y,Wu L,Liang L,Liang J

    更新日期:2020-04-14 00:00:00

  • The effects of cannabis use on oral health.

    abstract::Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. C...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13246

    authors: Liu C,Qi X,Yang D,Neely A,Zhou Z

    更新日期:2020-10-01 00:00:00

  • Relationship between the SF-36 questionnaire and patient's satisfaction following halitosis therapy.

    abstract:OBJECTIVE:To assess the health-related quality of life (HRQOL) of patients complaining of halitosis at their first visit and at a later time when their complaint had diminished following therapy, using a self-administered questionnaire, the Medical Outcome Study Short Form-36 (SF-36). The aim of this study was to exami...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01102.x

    authors: Kishi M,Abe A,Yonemitsu M

    更新日期:2005-01-01 00:00:00

  • Cytokeratins in epithelia of odontogenic neoplasms.

    abstract::Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithe...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.00861.x

    authors: Crivelini MM,de Araújo VC,de Sousa SO,de Araújo NS

    更新日期:2003-01-01 00:00:00

  • MMP and TIMP gene expression in head and neck squamous cell carcinomas and adjacent tissues.

    abstract:OBJECTIVE:To compare the frequency of gene expression of matrix metalloproteinases (MMP) stromelysins -1, -2 and -3 (MMP-3, -10, and -11), matrilysin (MMP-7), MTI-MMP (MMP-14), and of TIMPs (Tissue Inhibitors of MMPs) -1, -2, -3 and -4 in head and neck squamous cell carcinomas with those of matched adjacent normal tiss...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2000.tb00130.x

    authors: Birkedal-Hansen B,Pavelic ZP,Gluckman JL,Stambrook P,Li YQ,Stetler-Stevenson WG

    更新日期:2000-11-01 00:00:00

  • Betel and tobacco chewing habit and its relation to risk factors for periodontal disease.

    abstract:OBJECTIVES:To comparatively assess periodontal status in patients who chew different products and patients who do not have this habit and to assess how this practice interacts with predisposing factors and risk indicators of disease. METHODS:Patients included in the dental care carried out in a rural community in Indi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12820

    authors: Giovannoni ML,Valdivia-Gandur I,Lozano de Luaces V,Varela Véliz H,Balasubbaiah Y,Chimenos-Küstner E

    更新日期:2018-07-01 00:00:00

  • Patient-derived xenografts of a case of ameloblastic fibrodentinoma.

    abstract:OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13056

    authors: Pereira NB,de Souza JC,Bastos VC,Fonseca FP,de Avelar GF,Castro WH,Dias AAM,Mosqueda-Taylor A,Gomez RS,Gomes CC

    更新日期:2019-05-01 00:00:00

  • Bifunctional anticaries peptides with antibacterial and remineralizing effects.

    abstract:OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12990

    authors: Wang X,Wang Y,Wang K,Ren Q,Li H,Zheng S,Niu Y,Zhou X,Li W,Zhang L

    更新日期:2019-03-01 00:00:00

  • Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.

    abstract:OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12374

    authors: Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

    更新日期:2015-11-01 00:00:00

  • Increased beta 2 defensin in recurrent aphthous ulcer.

    abstract:OBJECTIVES:It was hypothesized that beta 2 defensin (BD-2) is increased in RAU lesions compared with healthy controls to promote anti-microbial host defence. METHODS:RAU and control mucosa samples were subjected to quantitative real-time PCR and immunostained for BD-2, CD68, mast cell tryptase and 4-hydroxynonenal (4H...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12262

    authors: Al-Samadi A,Salem A,Ainola M,Hietanen J,Häyrinen-Immonen R,Konttinen YT

    更新日期:2015-04-01 00:00:00

  • Oral complication risks after invasive and non-invasive dental procedures in HIV-positive patients.

    abstract:BACKGROUND:Limited published scientific evidence is available to provide guidance to clinicians on possible increased risks of invasive oral procedures associated with the human immunodeficiency virus (HIV) status of the patient. The aim of this study was to assess post-procedural complications in patients infected wit...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01262.x

    authors: Campo J,Cano J,del Romero J,Hernando V,Rodríguez C,Bascones A

    更新日期:2007-01-01 00:00:00

  • Hairy leukoplakia; lessons learned: 30-plus years.

    abstract::Well into the fourth decade of the HIV/AIDS pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. Prominent among these is oral hairy leukoplakia...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12393

    authors: Greenspan JS,Greenspan D,Webster-Cyriaque J

    更新日期:2016-04-01 00:00:00

  • Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw.

    abstract:OBJECTIVES:Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS:Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg k...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12513

    authors: de Barros Silva PG,de Oliveira CC,Brizeno L,Wong D,Lima Júnior R,Gonçalves RP,Sousa FB,Mota M,de Albuquerque Ribeiro R,Alves A

    更新日期:2016-10-01 00:00:00

  • Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review.

    abstract:OBJECTIVES:To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. METHODS:A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12113

    authors: Dhingra K

    更新日期:2014-04-01 00:00:00

  • Effect of HAART on salivary gland function in the Women's Interagency HIV Study (WIHS).

    abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...

    journal_title:Oral diseases

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1601-0825.2008.01456.x

    authors: Navazesh M,Mulligan R,Karim R,Mack WJ,Ram S,Seirawan H,Greenspan J,Greenspan D,Phelan J,Alves M,Oral Substudy of the Women's Interagency HIV Study Collaborative Study Group*.

    更新日期:2009-01-01 00:00:00

  • Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.

    abstract::Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12722

    authors: Li J,Ke X,Yan F,Lei L,Li H

    更新日期:2018-09-01 00:00:00

  • Viscosity and wettability of animal mucin solutions and human saliva.

    abstract:OBJECTIVE:The purpose of this study was to compare viscosity and wettability between animal mucin solutions and human saliva. MATERIALS AND METHODS:Human whole and glandular saliva, porcine gastric mucin, bovine submaxillary mucin, and a mucin-based saliva substitute were used. Viscosity was measured with a cone-and-p...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01263.x

    authors: Park MS,Chung JW,Kim YK,Chung SC,Kho HS

    更新日期:2007-03-01 00:00:00

  • Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws.

    abstract:OBJECTIVES:To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN:Retrospective case review. METHODS:The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2008.01494.x

    authors: Treister N,Sheehy N,Bae EH,Friedland B,Lerman M,Woo S

    更新日期:2009-01-01 00:00:00

  • TNF as marker of oral candidiasis, HSV infection, and mucositis onset during chemotherapy in leukemia patients.

    abstract:OBJECTIVE:To assess changes in the salivary expression of IL-1α, IL-1β, IL-2, IL-6, IL-10, IL-17, and TNF in acute leukemia (AL) patients before and during chemotherapy, and its association with HSV infection, oral candidiasis (OC), and oral mucositis (OM) onset. METHODS:Cohort study in AL patients >15 years starting ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12677

    authors: Ramírez-Amador V,Zambrano JG,Anaya-Saavedra G,Zentella-Dehesa A,Irigoyen-Camacho E,Meráz-Cruz N,Ponce de León-Rosales S

    更新日期:2017-10-01 00:00:00

  • Immunocompetent cells in oral candidiasis of HIV-infected patients: an immunohistochemical and electron microscopical study.

    abstract:OBJECTIVE:The purpose of this study was to elucidate the pathogenesis of oral candidiasis, a common cause of discomfort and social impairment among HIV-infected individuals. STUDY DESIGN, MATERIALS AND METHODS:The oral mucosal immune system cells were analysed by immunohistochemistry and electron microscopy in biopsie...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00020.x

    authors: Romagnoli P,Pimpinelli N,Mori M,Reichart PA,Eversole LR,Ficarra G

    更新日期:1997-06-01 00:00:00

  • The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations in major components of the PI3K/Akt/mTOR pathway are consistently observed throughout the majority of HNSCC cases. These alterations include gene...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12206

    authors: Vander Broek R,Mohan S,Eytan DF,Chen Z,Van Waes C

    更新日期:2015-10-01 00:00:00

  • Impact of modified acidic soft drinks on enamel erosion.

    abstract:OBJECTIVE:To evaluate the enamel erosive potential of modified acidic soft drinks under controlled conditions in an artificial mouth. MATERIALS AND METHODS:From each of 144 bovine incisors one enamel sample was prepared. Labial surfaces of the samples were ground flat, polished and covered with adhesive tape, leaving ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2004.01056.x

    authors: Attin T,Weiss K,Becker K,Buchalla W,Wiegand A

    更新日期:2005-01-01 00:00:00

  • Orofacial granulomatosis--a 20-year review.

    abstract::Orofacial granulomatosis (OFG) is the presence of persistent enlargement of the soft tissues of the oral and maxillofacial region, characterized by non-caseating granulomatous inflammation in the absence of diagnosable systemic Crohn's disease (CD) or sarcoidosis. Over 20 years have passed since OFG was first describe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01500.x

    authors: Grave B,McCullough M,Wiesenfeld D

    更新日期:2009-01-01 00:00:00

  • The impact of the world Workshops on oral health and disease in HIV and AIDS (1988-2020).

    abstract::The first World Workshop on Oral AIDS was held in San Diego in 1988, organized by John and Deborah Greenspan who saw the need and advantages of getting together all those health workers globally who were interested in oral aspects of HIV with a common purpose of advancing the field collectively and collaboratively. Si...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13385

    authors: Greenspan JS,Challacombe SJ

    更新日期:2020-09-01 00:00:00

  • Nutritional status in patients of mandibular osteoradionecrosis: A single-institution experience.

    abstract:BACKGROUND:Mandibular osteoradionecrosis (ORN) is a devastating complication secondary to the radiotherapy of head and neck cancer. The nutritional status of ORN patients is compromised, but remains rarely studied. We aimed to evaluate the overall nutritional status of patients with ORN and explore the risk factors beh...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13762

    authors: Huang Q,He X,Yang WF,Ye J,Lin Z,Xiong C,Liang YJ

    更新日期:2020-12-28 00:00:00

  • Influence of gender and stress on the volatile sulfur compounds and stress biomarkers production.

    abstract:BACKGROUND:Stress and menstrual cycle have been described as factors influencing bad breath, as they can alter oral homeostasis and contribute to the production of volatile sulfur compounds (VSC). OBJECTIVE:Considering that the experimenter's and volunteer's gender may influence the volunteer's responses to stress, th...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12011

    authors: Lima PO,Calil CM,Marcondes FK

    更新日期:2013-05-01 00:00:00

  • Osteomyelitis, osteoradionecrosis, or medication-related osteonecrosis of the jaws? Can CBCT enhance radiographic diagnosis?

    abstract:OBJECTIVE:To attempt defining differential radiographic diagnostic characteristics for osteonecrotic lesions using 2D as opposed to 3D images. MATERIALS AND METHODS:This was a cross-sectional study. Subjects presenting mandibular osteonecrotic lesions (osteomyelitis, osteoradionecrosis, and medication-related osteonec...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13534

    authors: Gaêta-Araujo H,Vanderhaeghen O,Vasconcelos KF,Coucke W,Coropciuc R,Politis C,Jacobs R

    更新日期:2021-03-01 00:00:00

  • Fourier Transform Infrared Imaging analysis of dental pulp inflammatory diseases.

    abstract:OBJECTIVES:Fourier Transform Infrared microspectroscopy let characterize the macromolecular composition and distribution of tissues and cells, by studying the interaction between infrared radiation and matter. Therefore, we hypothesize to exploit this analytical tool in the analysis of inflamed pulps, to detect the dif...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12635

    authors: Giorgini E,Sabbatini S,Conti C,Rubini C,Rocchetti R,Fioroni M,Memè L,Orilisi G

    更新日期:2017-05-01 00:00:00