Immunocompetent cells in oral candidiasis of HIV-infected patients: an immunohistochemical and electron microscopical study.

Abstract:

OBJECTIVE:The purpose of this study was to elucidate the pathogenesis of oral candidiasis, a common cause of discomfort and social impairment among HIV-infected individuals. STUDY DESIGN, MATERIALS AND METHODS:The oral mucosal immune system cells were analysed by immunohistochemistry and electron microscopy in biopsies from five erythematous and four pseudomembranous candidiasis cases and were compared with those from seven HIV-positive and 10 HIV-negative controls without candidiasis. RESULTS:The superficial lamina propria and basal epithelial layer was populated by CD1a+ Langerhans cells with infiltration of CD8+ lymphocytes. Within the submucosa are CD36+ dendritic macrophages and lymphocytes, although CD4+ subsets were absent from the infiltrate. The expression of human leukocyte antigen system, DR locus (HLA-DR) and leukocyte specific adhesion molecules was low in erythematous, yet more marked in pseudomembranous candidiasis. In the pseudomembranous form, CD14+ leukocytes were found in the basal epithelial layer. Langerhans cells were significantly more numerous and were richer in dendrites and Birbeck granules in erythematous than in pseudomembranous candidiasis. CONCLUSIONS:Candidiasis is associated with alterations in the number and differentiation of lymphocytes and dendritic cells, being more severe in the pseudomembranous than erythematous form. We propose that these alterations play a role in the pathogenesis and evolution of the disease.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Romagnoli P,Pimpinelli N,Mori M,Reichart PA,Eversole LR,Ficarra G

doi

10.1111/j.1601-0825.1997.tb00020.x

subject

Has Abstract

pub_date

1997-06-01 00:00:00

pages

99-105

issue

2

eissn

1354-523X

issn

1601-0825

journal_volume

3

pub_type

杂志文章
  • Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients.

    abstract:OBJECTIVES:The objective of this study was to identify the DNA of oral bacteria in placental samples from women with and without periodontitis who had or had not had preterm births and/or low birthweight (PB/LBW) neonates. METHODS:Data were gathered from 57 puerperal women in relation to socio-demographic, gynaecologi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12364

    authors: Blanc V,O'Valle F,Pozo E,Puertas A,León R,Mesa F

    更新日期:2015-10-01 00:00:00

  • Elder neglect-Oral diseases and injuries.

    abstract::Elder neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandato...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12797

    authors: Petti S

    更新日期:2018-09-01 00:00:00

  • Borate bioactive glass prevents zoledronate-induced osteonecrosis of the jaw by restoring osteogenesis and angiogenesis.

    abstract:OBJECTIVES:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen-containing bisphosphonate (N-BP) administration, which leads to osteonecrosis, pain, and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potentia...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13436

    authors: Su Z,Li J,Bai X,Tay FR,Zhang M,Liang K,He L,Yuan H,Li J

    更新日期:2020-11-01 00:00:00

  • An update of knowledge on the regulatory role of Treg cells in apical periodontitis.

    abstract::Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals, thereb...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13450

    authors: Wei L,Xu M,Xiong H

    更新日期:2020-06-02 00:00:00

  • Pathogenesis investigation of miR-199-5p in oral submucous fibrosis based on bioinformatics analysis.

    abstract:OBJECTIVES:Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes. MATERIALS AND METHODS:By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Bi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13008

    authors: Yuan Y,Li N,Zeng L,Shen Z,Jiang C

    更新日期:2019-03-01 00:00:00

  • Hairy leukoplakia; lessons learned: 30-plus years.

    abstract::Well into the fourth decade of the HIV/AIDS pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. Prominent among these is oral hairy leukoplakia...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12393

    authors: Greenspan JS,Greenspan D,Webster-Cyriaque J

    更新日期:2016-04-01 00:00:00

  • HIV diagnosis and testing: what every healthcare professional can do (and why they should).

    abstract::Over the last thirty years, the human immunodeficiency virus (HIV) epidemic has matured. In the United States, HIV has changed from an explosive outbreak to an endemic disease; currently, an estimated 1.1 million people are infected with HIV, including a substantial number who are unaware of their status. With recent ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12047

    authors: Wilson E,Tanzosh T,Maldarelli F

    更新日期:2013-07-01 00:00:00

  • Age-related dental phenotypes and tooth characteristics of FAM83H-associated hypocalcified amelogenesis imperfect.

    abstract:OBJECTIVES:Autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) shows phenotypic heterogeneity. Our aim was to characterise the ADHCAI phenotypes, tooth properties and genotypes. METHODS:Three unrelated ADHCAI probands and seven additional affected members of the three families were recruited. Mutations w...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13780

    authors: Sriwattanapong K,Nitayavardhana I,Theerapanon T,Thaweesapphithak S,Chantarawaratit PO,Garuyakich R,Phokaew C,Porntaveetus T,Shotelersuk V

    更新日期:2021-01-24 00:00:00

  • Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.

    abstract:OBJECTIVES:To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. SUBJECTS AND METHODS:Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13337

    authors: Penteado CAS,Batista TBD,Chaiben CL,Bonacin BG,Ventura TMO,Dionizio A,Couto Souza PH,Buzalaf MAR,Azevedo-Alanis LR

    更新日期:2020-04-01 00:00:00

  • The effects of cannabis use on oral health.

    abstract::Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. C...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13246

    authors: Liu C,Qi X,Yang D,Neely A,Zhou Z

    更新日期:2020-10-01 00:00:00

  • Chemokines and chemokine receptors: the key to understanding AIDS.

    abstract::This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...

    journal_title:Oral diseases

    pub_type: 社论,评审

    doi:10.1111/j.1601-0825.1997.tb00002.x

    authors: Thornhill MH,Li J

    更新日期:1997-03-01 00:00:00

  • Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry.

    abstract:OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00096.x

    authors: Takahashi K,MacDonald D,Murayama Y,Kinane D

    更新日期:1999-10-01 00:00:00

  • Alpha-lipoic acid treatment of 31 patients with sore, burning mouth.

    abstract:OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01414.x

    authors: Steele JC,Bruce AJ,Drage LA,Rogers RS 3rd

    更新日期:2008-09-01 00:00:00

  • Andrographolide-loaded solid lipid nanoparticles enhance anti-cancer activity against head and neck cancer and precancerous cells.

    abstract:BACKGROUND:Increasing evidence indicates that andrographolide (ADG) exhibits anti-cancer activity against various cancer cell lines. However, its high hydrophobicity and poor bioavailability restrict its clinical application as a chemopreventative agent. Previously, we have shown that ADG-loaded solid lipid nanoparticl...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13751

    authors: Li H,Qu X,Qian W,Song Y,Wang C,Liu W

    更新日期:2020-12-09 00:00:00

  • Detection of distant metastasis and prognostic prediction of recurrent salivary gland carcinomas using 18 F-FDG PET/CT.

    abstract:OBJECTIVE:To compare the diagnostic accuracy of 18 F-FDG PET/CT and conventional contrast-enhanced CT for the re-staging of recurrent salivary gland carcinoma (SGC). MATERIALS AND METHODS:This study included 58 consecutive patients who underwent recurrent SGCs after definitive treatment. The recurrences were evaluated...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12877

    authors: Lee SH,Roh JL,Kim JS,Lee JH,Choi SH,Nam SY,Kim SY

    更新日期:2018-09-01 00:00:00

  • World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review.

    abstract:OBJECTIVE:To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records. MATERIALS AND METHODS:A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13112

    authors: Hong CHL,Dean DR,Hull K,Hu SJ,Sim YF,Nadeau C,Gonçalves S,Lodi G,Hodgson TA

    更新日期:2019-06-01 00:00:00

  • Current and historical involvement of dentistry in child protection and a glimpse of the future.

    abstract::Dental teams have been involved with child protection for over 40 years. This brief review summarises their involvement in the detection of various types of child abuse and goes on to discuss the gap between the proportions of dental professionals who suspect child abuse or neglect in their paediatric patients and tho...

    journal_title:Oral diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/odi.12485

    authors: Park CM,Welbury R

    更新日期:2016-10-01 00:00:00

  • Periodontitis in patients with psoriasis: A systematic review and meta-analysis.

    abstract:OBJECTIVE:The present study aimed to summarize and update the evidence regarding the association between periodontitis and psoriasis. METHODS:The present systematic review was conducted under the guidelines of Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) and was recorded in the PROSPERO datab...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13617

    authors: Zhang X,Gu H,Xie S,Su Y

    更新日期:2020-08-27 00:00:00

  • Oral lichen planus: controversies surrounding malignant transformation.

    abstract::Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure t...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01441.x

    authors: Gonzalez-Moles MA,Scully C,Gil-Montoya JA

    更新日期:2008-04-01 00:00:00

  • Oral bacterial diversity is inversely correlated with mucosal inflammation.

    abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13420

    authors: Hijazi K,Morrison RW,Mukhopadhya I,Martin B,Gemmell M,Shaw S,Santoro F

    更新日期:2020-10-01 00:00:00

  • Pharmacodiagnostic evaluation of EGFR expression in oral squamous cell carcinoma.

    abstract:OBJECTIVE:To determine epidermal growth factor receptor (EGFR) expression in oral squamous cell carcinomas (OSCC), and its possible relationships with clinical findings, histological findings, disease course and prognosis. MATERIALS AND METHODS:Surgical specimens of 47 OSCCs were studied immunohistochemically for dete...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01280.x

    authors: Diniz-Freitas M,García-Caballero T,Antúnez-López J,Gándara-Rey JM,García-García A

    更新日期:2007-05-01 00:00:00

  • Neuralgia-inducing cavitational osteonecrosis: a status report.

    abstract::Neuralgia-inducing cavitational osteonecrosis remains controversial several years following the initial description. Changing etiologic concepts have led to confusion as well as the significant departures from the concept first defined by Ratner which served as the basis for the explaining the pain syndrome with featu...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01532.x

    authors: Sciubba JJ

    更新日期:2009-07-01 00:00:00

  • Prevalence of oral disease among adults with primary HIV infection.

    abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01407.x

    authors: Owotade FJ,Shiboski CH,Poole L,Ramstead CA,Malvin K,Hecht FM,Greenspan JS

    更新日期:2008-09-01 00:00:00

  • The paradox of painless periodontal disease.

    abstract::Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12537

    authors: Gaurilcikaite E,Renton T,Grant AD

    更新日期:2017-05-01 00:00:00

  • Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway.

    abstract:OBJECTIVES:Toll-like receptor 4 (TLR4) is abnormally expressed in oral cancer tissues and promotes cancer cell invasion. The purpose of this study was to clarify the mechanism by which autophagy regulates oral cancer invasion through the TLR4-NF-κB pathway. SUBJECTS AND METHODS:We examined TLR4 expression in oral canc...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13355

    authors: Kong Q,Liang Y,He Q,You Y,Wu L,Liang L,Liang J

    更新日期:2020-04-14 00:00:00

  • Influence of oestrogen deficiency and excessive mechanical stress on condylar head of mandible.

    abstract:OBJECTIVE:We assessed the aetiology of idiopathic condylar resorption by examining the effects of oestrogen and compressive mechanical stress under a low systemic oestrogen condition in temporomandibular joints (TMJ) caused by an ovariectomy. MATERIALS AND METHODS:Female rabbits were divided into non-ovariectomy (non-...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13452

    authors: Nogami S,Yamauchi K,Odashima K,Ito K,Iikubo M,Kumasaka A,Martinez-de la Cruz G,Gaggl A,Kumamoto H,Takahashi T

    更新日期:2020-11-01 00:00:00

  • Local drug delivery for oral mucosal diseases: challenges and opportunities.

    abstract::There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue pe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01793.x

    authors: Sankar V,Hearnden V,Hull K,Juras DV,Greenberg MS,Kerr AR,Lockhart PB,Patton LL,Porter S,Thornhill M

    更新日期:2011-04-01 00:00:00

  • Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

    abstract:OBJECTIVES:Salivary glands are useful target organs for local and systemic gene therapeutics. For such applications, the regulation of transgene expression is important. Previous studies by us in murine submandibular glands showed that a rapamycin transcriptional regulation system in a single serotype 2, adeno-associat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01631.x

    authors: Zheng C,Voutetakis A,Metzger M,Afione S,Cotrim AP,Eckhaus MA,Rivera VM,Clackson T,Chiorini JA,Donahue RE,Dunbar CE,Baum BJ

    更新日期:2010-04-01 00:00:00

  • Nitric oxide synthesis and severity of human periodontal disease.

    abstract:UNLABELLED:The expression of the inducible nitric oxide synthase enzyme (iNOS) is a response to an inflammatory stimulus and produces a large amount of nitric oxide (NO), which may act as a cytotoxic molecule against the invading microorganism and may be related to both harmful and beneficial effects to tissues. OBJEC...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2002.02852.x

    authors: Batista AC,Silva TA,Chun JH,Lara VS

    更新日期:2002-09-01 00:00:00

  • Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells.

    abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12552

    authors: Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

    更新日期:2016-11-01 00:00:00