Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells.

Abstract:

OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent and in combination with irradiation and chemotherapy. METHODS:Effects of neratinib were evaluated in HNSCC cell lines CAL27, SCC25 and FaDu. Effect on cell viability of neratinib and combination with cisplatin and irradiation was measured using CCK-8 assays and clonogenic assays. Western blot analysis was performed to distinguish the effect on epithelial growth factor receptor and HER2 expression. Apoptosis was evaluated by flow cytometry analysis. RESULTS:Growth inhibition was achieved in all cell lines, whereas combination of cisplatin and neratinib showed greater inhibition than each agent alone. Apoptosis was induced in all cell lines. Combination of neratinib with irradiation or cisplatin showed significantly increased apoptosis. In clonogenic assays, significant growth inhibition was observed in all investigated cell lines. CONCLUSION:Neratinib, as a single agent or in combination with chemo-irradiation, may be a promising treatment option for patients with head and neck cancer.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

doi

10.1111/odi.12552

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

797-804

issue

8

eissn

1354-523X

issn

1601-0825

journal_volume

22

pub_type

杂志文章
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    abstract:OBJECTIVE:This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes. DESIGN:MEDLINE search of the English language literature identified primary research reports published on (a) relationships between diabetes and pe...

    journal_title:Oral diseases

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    doi:10.1111/j.1601-0825.2008.01442.x

    authors: Taylor GW,Borgnakke WS

    更新日期:2008-04-01 00:00:00

  • Evaluation of periodontal parameters in patients undergoing peritoneal dialysis or hemodialysis.

    abstract:OBJECTIVE:To analyze and compare periodontal parameters in chronic renal failure (CRF) patients undergoing peritoneal dialysis (PD) therapy with a group of patients on hemodialysis (HD) treatment and healthy controls (C). PARTICIPANTS:Seventy-five PD patients (mean age: 44 +/- 12 years) were matched with 41 HD patient...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01372.x

    authors: Bayraktar G,Kurtulus I,Kazancioglu R,Bayramgurler I,Cintan S,Bural C,Bozfakioglu S,Besler M,Trablus S,Issever H,Yildiz A

    更新日期:2008-03-01 00:00:00

  • Hyperbaric oxygen therapy and osteonecrosis.

    abstract::Osteonecrosis of the jaw may be caused by radiation, medication, or infection. Optimal therapy requires a multimodal approach that combines surgery with adjuvant treatments. This review focuses on the use of adjunctive hyperbaric oxygen therapy for this condition. In addition to evidence regarding the basic and clinic...

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    doi:10.1111/odi.12489

    authors: Ceponis P,Keilman C,Guerry C,Freiberger JJ

    更新日期:2017-03-01 00:00:00

  • The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study.

    abstract:OBJECTIVE:The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT). PATIENTS AND METHODS:The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treat...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.1997.tb00049.x

    authors: Cohen G,Elad S,Or R,Galili D,Garfunkel AA

    更新日期:1997-12-01 00:00:00

  • The deep mycoses in HIV infection.

    abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00361.x

    authors: Scully C,de Almeida OP,Sposto MR

    更新日期:1997-05-01 00:00:00

  • Plasmablastic lymphoma: a review.

    abstract::Plasmablastic lymphoma (PBL) has been recently characterised as an aggressive subtype of non-Hodgkin's lymphoma, most frequently arising in the oral cavity of HIV-infected patients. To date, approximately 60 cases fulfilling the clinico-pathological characteristics of PBL have been reported. PBLs are composed of large...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01493.x

    authors: Rafaniello Raviele P,Pruneri G,Maiorano E

    更新日期:2009-01-01 00:00:00

  • Relationship between periodontal disease and male infertility: A case-control study.

    abstract:OBJECTIVES:To compare the prevalence of chronic periodontitis between men who had semen abnormalities and those who had normozoospermia through a case-control study. MATERIALS AND METHODS:Male patients who visited the assisted reproduction clinic of a large general hospital and were diagnosed with semen abnormalities ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13552

    authors: Tao DY,Zhu JL,Xie CY,Kuang YP,Chai WR,Lo ECM,Ye W,Li F,Feng XP,Lu HX

    更新日期:2020-07-23 00:00:00

  • Accumulation of strontium and fluoride in approximal dental plaque and changes in plaque microflora after rinsing with chlorhexidine-fluoride-strontium solution.

    abstract:OBJECTIVES:To find out if strontium is incorporated into plaque and enamel in vivo during a 2-week rinsing period with a chlorhexidine-fluoride-strontium solution and to determine the effects of the rinsing on the numbers of mutans streptococci and lactobacilli in plaque. SUBJECTS AND METHODS:A total of 18 adult parti...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1601-0825.1998.tb00267.x

    authors: Spets-Happonen S,Seppä L,Korhonen A,Alakuijala P

    更新日期:1998-06-01 00:00:00

  • Neuralgia-inducing cavitational osteonecrosis: a status report.

    abstract::Neuralgia-inducing cavitational osteonecrosis remains controversial several years following the initial description. Changing etiologic concepts have led to confusion as well as the significant departures from the concept first defined by Ratner which served as the basis for the explaining the pain syndrome with featu...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01532.x

    authors: Sciubba JJ

    更新日期:2009-07-01 00:00:00

  • Sex differences in the hypothalamic-pituitary-adrenal axis in patients with burning mouth syndrome.

    abstract:OBJECTIVE:To investigate the sex differences in clinical features, including salivary flow rate, psychological distress and hypothalamic-pituitary-adrenal axis response and their inter-relationships in patients with burning mouth syndrome. SUBJECTS AND METHODS:Eighteen men and 37 postmenopausal women with burning mout...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13195

    authors: Lee YH,An JS,Chon S

    更新日期:2019-11-01 00:00:00

  • Regeneration of lingual musculature in rats using myoblasts over porcine bladder acellular matrix.

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    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13674

    authors: Camacho-Alonso F,García-Carrillo N,Buendía AJ,Navarro JA,Peñarrocha-Oltra D,Peñarrocha-Diago M,Lacal-Luján J

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  • Cytokeratins in epithelia of odontogenic neoplasms.

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    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.00861.x

    authors: Crivelini MM,de Araújo VC,de Sousa SO,de Araújo NS

    更新日期:2003-01-01 00:00:00

  • Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer.

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    pub_type: 杂志文章

    doi:10.1111/odi.13366

    authors: Fanetti G,Alterio D,Marvaso G,Gandini S,Rojas DP,Gobitti C,Minatel E,Revelant A,Caroli A,Francia CM,Alessandro O,Pepa M,Gugliandolo SG,Starzyńska A,Polesel J,Vaccher E,Cossu Rocca M,Tagliabue M,Ansarin M,Lupato V,

    更新日期:2020-10-01 00:00:00

  • Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature.

    abstract:OBJECTIVE:Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. The purpose of this study was to evaluate the clinical outcomes of MEC of minor salivary glands in a group of 16 patients, w...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2005.01166.x

    authors: Triantafillidou K,Dimitrakopoulos J,Iordanidis F,Koufogiannis D

    更新日期:2006-07-01 00:00:00

  • Comparative effects of various commercially available mouthrinse formulations on oral malodor.

    abstract:OBJECTIVES:The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2010.01714.x

    authors: Saad S,Greenman J,Shaw H

    更新日期:2011-03-01 00:00:00

  • Locally delivered antimicrobials for the treatment of chronic periodontitis.

    abstract::The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1034/j.1601-0825.9.s1.8.x

    authors: Etienne D

    更新日期:2003-01-01 00:00:00

  • Rehabilitation of lost teeth related to maintenance of cognitive function.

    abstract:OBJECTIVE:As the era of aging comes, cognitive impairment (CI) is increasing. The impact of rehabilitation of lost tooth on CI remains unclear. This study aimed to investigate whether non-rehabilitated lost teeth (NRLT) is associated with CI among Korean elders. METHODS:A total of 280 elders comprising of 140 cases an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12960

    authors: Shin MS,Shin YJ,Karna S,Kim HD

    更新日期:2019-01-01 00:00:00

  • Palatal zygomycosis: experience of 21 cases.

    abstract:OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a bi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01433.x

    authors: Bonifaz A,Macias B,Paredes-Farrera F,Arias P,Ponce RM,Araiza J

    更新日期:2008-09-01 00:00:00

  • Cyclin D1-induced proliferation is independent of beta-catenin in head and neck cancer.

    abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. The current study a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12124

    authors: Sales KU,Giudice FS,Castilho RM,Salles FT,Squarize CH,Abrahao AC,Pinto DS Jr

    更新日期:2014-04-01 00:00:00

  • Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients--randomized study.

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    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2012.01943.x

    authors: Gilowski L,Kondzielnik P,Wiench R,Płocica I,Strojek K,Krzemiński TF

    更新日期:2012-11-01 00:00:00

  • Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.

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    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12374

    authors: Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

    更新日期:2015-11-01 00:00:00

  • Surface properties of lactobacilli isolated from healthy subjects.

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    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2000.tb00118.x

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    更新日期:2000-07-01 00:00:00

  • Oral lichen planus: a preliminary clinical study on treatment with tazarotene.

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    pub_type: 临床试验,杂志文章,随机对照试验

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  • ELISA test for p63 antibodies in chronic ulcerative stomatitis.

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    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01606.x

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  • Effect of the three Enterococcus faecalis strains on apoptosis in MC3T3 cells.

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    pub_type: 杂志文章

    doi:10.1111/odi.12883

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    更新日期:2019-01-01 00:00:00

  • Functional variants of IL4 and IL6 genes and risk of tobacco-related oral carcinoma in high-risk Asian Indians.

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    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2011.01831.x

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  • Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

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    pub_type: 杂志文章,评审

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    authors: Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

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  • Is erythematous candidiasis associated with advanced HIV disease?

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    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00339.x

    authors: Robinson PG,Challacombe SJ,Sheiham A,Zakrzewska JM

    更新日期:1997-05-01 00:00:00

  • Dental considerations for the paediatric AIDS/HIV patient.

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    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2002.00012.x

    authors: Ramos-Gomez F

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