Abstract:
OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients was a prescription/recommendation for alpha-lipoic acid. Of these patients, 35 were available for follow-up. SETTING:Tertiary care academic medical center. SUBJECTS:Ambulatory patients given prescription /recommendation for alpha-lipoic acid 600 mg per day, in divided doses. MAIN OUTCOME MEASURE:Reported improvement in symptoms documented in medical records and at follow-up (visits or telephone interviews). RESULTS:Thirty-one of the 35 patients (66% of all 47) actually took alpha-lipoic acid as recommended. No patient reported a complete alleviation of symptoms. Six (19%) of these 31 patients felt mostly better, five (16%) felt somewhat better, and 14 (45%) reported no difference. Two patients (7%) reported a worsening of symptoms and four (13%) did not know whether there had been improvement. CONCLUSION:Eleven of 31 patients (35%) reported benefit from taking alpha-lipoic acid. Because we examined only a small number of patients and relied on a subjective outcome assessment, further larger studies using a prospective, randomized, controlled, and double-blind structure are warranted.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Steele JC,Bruce AJ,Drage LA,Rogers RS 3rddoi
10.1111/j.1601-0825.2007.01414.xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
529-32issue
6eissn
1354-523Xissn
1601-0825pii
ODI1414journal_volume
14pub_type
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