Abstract:
OBJECTIVE:Osteoblast apoptosis is critical for the development and repairing of bone destruction in persistent apical periodontitis (PAP). Enterococcus faecalis is considered as a frequently isolated pathogen of PAP. This study aimed to explore the effect of E. faecalis on apoptosis in osteoblastic MC3T3-E1 cells via an in vitro model. MATERIALS AND METHODS:MC3T3 cells were incubated with live clinically isolated strains of E. faecalis at a multiplicity of infection (MOI) of 1,000:1 for 2 hr. Flow cytometry analysis using annexin V-FITC and PI staining, JC-1 staining and TUNEL assay were conducted to detect the apoptosis in the infected cells. Western blotting and quantitative real-time PCR were used to determine the expression of caspase-3, Bcl-2 and Bax. RESULTS:The proliferation of the infected cells was inhibited. Decreased mitochondrial membrane potential (ΔΨm) and enhanced DNA fragmentation of the infected cells were observed. The relative expression of Bax and cleavage caspase-3 was upregulated, and the expression of Bcl-2 and Bcl-2/Bax was downregulated in the infected cells. CONCLUSION:Together, the clinically isolated strains of E. faecalis can induce apoptosis in MC3T3 osteoblasts, which may be attributed to the regulation of interaction between members of the Bcl-2 family.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Li Y,Tong Z,Ling Jdoi
10.1111/odi.12883subject
Has Abstractpub_date
2019-01-01 00:00:00pages
309-318issue
1eissn
1354-523Xissn
1601-0825journal_volume
25pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract::Dental research over the last century has advanced our understanding of the etiology and pathogenesis of caries lesions. Increasing knowledge of the dynamic demineralization/remineralization processes has led to the current consensus that bacteria-mediated tooth destruction can be arrested or even to some degree rever...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2004.01030.x
更新日期:2004-09-01 00:00:00
abstract::Radiation-induced hyposalivation is still a major problem after radiotherapy for head and neck cancer. Current and promising new thoughts to reduce or salvage radiation damage to salivary gland tissue are explored. The main cause underlying radiation-induced hyposalivation is a lack of functional saliva-producing acin...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12222
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS:Haematoxylin and eosin stained sections of 51 cases of AOT were revi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01399.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS:Surgically removed oral tumours (n = 103) we...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12696
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision ma...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13199
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12552
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:A multicentre collaborative study by the London HIV and Dentistry Group failed to associate the presence of erythematous candidiasis (EC) with advanced HIV disease. Data from a study of the periodontal health of homosexual men attending a genito-urinary medicine clinic presented an opportunity to investigate...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00339.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Sodium lauryl sulphate (SLS), an important component in many oral health products, is well established as a contact irritant in skin. Recent studies have suggested that it may also affect the structural integrity of oral mucosa. SLS is rarely used alone in dentifrices or mouthwashes and the aim of this study ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2000.tb00112.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13056
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by ...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2010.01714.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP). METHODS:Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. ...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2012.01943.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:This article sets out to evaluate the prevalence and aetiopathogenesis of edentulism in patients on haemodialysis. SUBJECTS AND METHODS:The study group comprised 44 adult patients with end-stage renal disease (ESRD) on haemodialysis. A control group was formed of 44 individuals matched for age and sex and wi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12486
更新日期:2016-09-01 00:00:00
abstract:UNLABELLED:Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 at the 1p36 region and p63 at the 3q27-29 region, have recently been identified. They share considerable sequence homolog...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.02920.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVES:This review aims to evaluate the efficacy of xenogeneic collagen matrix (XCM) for the treatment of single or multiple gingival recessions in terms of clinical parameters and patient-related outcomes. MATERIALS AND METHODS:Various electronic databases (The Cochrane Central Register of Controlled Trials, MEDL...
journal_title:Oral diseases
pub_type: 杂志文章,meta分析
doi:10.1111/odi.12949
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:siRNA-induced gene silencing in the salivary gland using microbubble-enhanced sonoporation was used to develop an in vivo gene knockdown technique. METHODS:siRNA targeting rat glyceraldehyde-3-phosphate dehydrogenas (GAPDH) was mixed with echo-enhanced microbubbles and reverse-injected into rat parotid glan...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01579.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To examine oral complications 6 months after modern radiation therapy (RT) for head and neck cancer (HNC). METHODS:Prospective multicenter cohort study of patients with HNC receiving intensity-modulated radiation therapy or more advanced RT. Stimulated whole salivary flow, maximal mouth opening, oral mucosit...
journal_title:Oral diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/odi.12710
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes. DESIGN:MEDLINE search of the English language literature identified primary research reports published on (a) relationships between diabetes and pe...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2008.01442.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...
journal_title:Oral diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1601-0825.2008.01456.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To test whether the submandibular/sublingual (SMSL) salivary secretion, mucin concentration and candida carriage status were altered in human immunodeficiency virus-positive (HIV+) patients. SUBJECTS AND METHODS:SMSL saliva collected from 48 HIV-infected and 31 HIV-negative men were analyzed for flow rates,...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01514.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13420
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12990
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVES:To propose the application of the concept of geriatric syndrome for common geriatric oral and maxillofacial dysfunctions and to suggest the necessity of developing effective evaluation methods for oral and maxillofacial frailty. DESIGN:The concepts of frailty and geriatric syndrome based on multi-morbidity ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12647
更新日期:2018-04-01 00:00:00
abstract::HIV infection and AIDS are spreading rapidly among the world's children, especially among African-American and Hispanic children in the USA, and those in developing countries. Although recent research has identified several ways of preventing perinatal transmission of HIV, most of these methods are too expensive for w...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.00012.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To explore the type and prevalence of oral mucosal lesions among adults with primary HIV infection (PHI) compared with HIV-negative adults at high risk for HIV disease, and in relation to HIV viral load. METHODS:We conducted standardized oral examinations to identify specific oral mucosal lesions among adult...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01407.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVES:The access to probiotics should be facilitated in order to encourage their usage. We evaluated the effect of consumption of two experimental probiotic-containing cheeses on the oral colonization of Candida in denture wearers. METHODS:Sixty denture wearers harboring oral Candida were randomly allocated in gr...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/odi.12669
更新日期:2017-10-01 00:00:00
abstract::There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue pe...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2011.01793.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were per...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13437
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND:Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expre...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01395.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:For clinical applications of biomarkers, there is a need for multiplex assays using high throughput platforms. The objective of this study was to determine the efficacy of Luminex Multianalyte Profiling (xMAP) technology for measurement of salivary proteins and to evaluate whether multiplex assays are as effe...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2008.01488.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To determine the effects of fluorides on endothelial functioning. MATERIALS AND METHODS:We analyzed expressions of adhesion molecules, ICAM-1 and ICAM-3, and annexin V, on the surface of human umbilical vein endothelial cells (HUVECs) exposed to various concentrations of NaF and SnF(2) . We compared the effe...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2011.01873.x
更新日期:2012-04-01 00:00:00