Alterations in expression of retinoid receptor beta and p53 in oral submucous fibrosis.

Abstract:

OBJECTIVE:Knowledge of the molecular pathogenesis of oral submucous fibrosis (OSF), a potentially malignant condition with high risk of transition to oral cancer, is meagre. Alterations in the expression of retinoic acid receptor beta (RARbeta) and tumor suppressor gene, p53 are early events in oral tumorigenesis. The aim of this study was to investigate the alterations in the expression of RARbeta and p53 in OSF lesions and determine their association with disease pathogenesis. METHODS:The expression of RARbeta and p53 proteins was analyzed by immunohistochemistry in 50 cases of OSF and 30 histologically normal oral tissues. RESULTS:No detectable RARbeta expression was observed in 35 of 50 (70%) OSF cases. p53 protein accumulation was observed in 24 of 50 (48%) OSF cases analyzed. Thirty-six percent OSF lesions showed loss of RARbeta and p53 overexpression. Interestingly, 41 of 50 (82%) of OSF lesions showed altered expression of at least one of these two proteins. CONCLUSION:Altered expression of either RARbeta or p53 in majority of OSF lesions suggests their association with disease pathogenesis and warrants follow-up to determine whether OSF lesions harboring concomitant alterations in RARbeta and p53 are at a high risk of transition to malignancy.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Kaur J,Chakravarti N,Mathur M,Srivastava A,Ralhan R

doi

10.1111/j.1601-0825.2004.00993.x

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

201-6

issue

4

eissn

1354-523X

issn

1601-0825

pii

ODI993

journal_volume

10

pub_type

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