Defining the genomic landscape of head and neck cancers through next-generation sequencing.

abstract：OBJECTIVE:To compare the frequency of gene expression of matrix metalloproteinases (MMP) stromelysins -1, -2 and -3 (MMP-3, -10, and -11), matrilysin (MMP-7), MTI-MMP (MMP-14), and of TIMPs (Tissue Inhibitors of MMPs) -1, -2, -3 and -4 in head and neck squamous cell carcinomas with those of matched adjacent normal tiss...

journal_title：Oral diseases

authors： Birkedal-Hansen B,Pavelic ZP,Gluckman JL,Stambrook P,Li YQ,Stetler-Stevenson WG

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:We evaluated the prevalence of hepatitis virus infection in a large population of patients in terms of diseases requiring oral surgery. DESIGN:Retrospective case survey. SUBJECTS AND METHODS:Prevalence of hepatitis B and C virus (HBV, HCV) infection were compared between oral diseases such as inflammation, ...

journal_title：Oral diseases

authors： Takata Y,Takahashi T,Fukuda J

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...

journal_title：Oral diseases

authors： Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Orofacial clefts (OFCs) are common and etiologically complex birth defects. This study explored potential genetic differences in a pair of Japanese monozygotic (MZ) twins with different forms of OFC using whole-genome sequencing. SUBJECTS AND METHODS:One co-twin (MZ-1) presented with nonsyndromic bilateral c...

journal_title：Oral diseases

authors： Takahashi M,Hosomichi K,Yamaguchi T,Nagahama R,Yoshida H,Maki K,Marazita ML,Weinberg SM,Tajima A

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the levels, molecular forms and activation degree of matrix metalloproteinase-13 (MMP-13) in the gingival crevicular fluid (GCF) of patients with periodontal diseases and to correlate these findings with periodontal clinical parameters. METHODS:Sixty one subjects pa...

journal_title：Oral diseases

authors： Ilgenli T,Vardar-Sengul S,Gürkan A,Sorsa T,Stackelberg S,Köse T,Atilla G

更新日期：2006-11-01 00:00:00

abstract：:DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Of the all epigenetic modifications, methylation, which represses transcription of the promoter region of tumor suppressor genes leading to gene silencing, ha...

journal_title：Oral diseases

authors： González-Ramírez I,García-Cuellar C,Sánchez-Pérez Y,Granados-García M

更新日期：2011-11-01 00:00:00

abstract：:The traditional concept of caries as a multifactorial transmittable and infectious disease has been challenged. Novel conceptual ideas have come to add to the complexity of this highly prevalent disease worldwide. Current etiological understanding of the disease has emphasized the pivotal role of sugars in caries. In ...

journal_title：Oral diseases

authors： Giacaman RA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of dental pain among adolescent students and its association with individual, school and city variables, using a multilevel approach. SUBJECTS AND METHODS:Individual and school data were obtained from the National Adolescent School-Based Health Survey (PeNSE) conducted in Brazil...

journal_title：Oral diseases

authors： Freire MCM,Nery NG,Jordão LMR,Abreu MHNG

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:CD10 is expressed on the majority of follicle-center lymphomas and Burkitt lymphomas. CD10 has also been shown to be present in a variety of other neoplasms. DESIGN:The aim of this study was a correlation of CD10 and several parameters: age, tumor size, presence of lymph node metastases, clinic stage, histol...

journal_title：Oral diseases

authors： Piattelli A,Fioroni M,Iezzi G,Perrotti V,Stellini E,Piattelli M,Rubini C

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...

journal_title：Oral diseases

authors： Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

更新日期：2015-11-01 00:00:00

abstract：UNLABELLED:The expression of the inducible nitric oxide synthase enzyme (iNOS) is a response to an inflammatory stimulus and produces a large amount of nitric oxide (NO), which may act as a cytotoxic molecule against the invading microorganism and may be related to both harmful and beneficial effects to tissues. OBJEC...

journal_title：Oral diseases

authors： Batista AC,Silva TA,Chun JH,Lara VS

更新日期：2002-09-01 00:00:00

abstract：:There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue pe...

journal_title：Oral diseases

authors： Sankar V,Hearnden V,Hull K,Juras DV,Greenberg MS,Kerr AR,Lockhart PB,Patton LL,Porter S,Thornhill M

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on fo...

journal_title：Oral diseases

authors： Putt MS,Kleber CJ

更新日期：1995-06-01 00:00:00

abstract：:Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...

journal_title：Oral diseases

authors： Warnakulasuriya S,Kujan O,Aguirre-Urizar JM,Bagan JV,González-Moles MÁ,Kerr AR,Lodi G,Mello FW,Monteiro L,Ogden GR,Sloan P,Johnson NW

更新日期：2020-10-31 00:00:00

abstract：OBJECTIVES:To assess the effects of periodontitis on renal interstitial fibrosis in a mouse model. MATERIALS AND METHODS:Thirty C57BL/6 male mice were divided into control, periodontitis (PD), unilateral ureteral ligation (UUO) and PD+UUO groups. Unilateral ureteral ligation was performed 6 days after periodontitis. A...

journal_title：Oral diseases

authors： Bi C,Han XL,Li XZ,Sun JY,Liu Y,Duan SZ,Lu HX

更新日期：2020-12-31 00:00:00

abstract：:Patient and public involvement (PPI) is a process whereby patients, caregivers, service users and other relevant stakeholders, including the general public, are actively involved and engaged in activities to develop research. The dental research agenda has traditionally been driven by clinicians, where patients and th...

journal_title：Oral diseases

authors： Sharma Mahendra V,Ranauta A,Yuvraj A,Santella AJ,Taslim A,Doughty J

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVES:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen-containing bisphosphonate (N-BP) administration, which leads to osteonecrosis, pain, and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potentia...

journal_title：Oral diseases

authors： Su Z,Li J,Bai X,Tay FR,Zhang M,Liang K,He L,Yuan H,Li J

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To describe the clinical and genetic features of patients with cherubism. MATERIAL AND METHODS:A descriptive analysis of 14 cases from nine different families was carried out. Clinicopathological, imaging, and follow-up data were retrieved from patients' medical files and correlated with the genetic profile ...

journal_title：Oral diseases

authors： Machado RA,Pontes H,Pires FR,Silveira HM,Bufalino A,Carlos R,Tuji FM,Alves D,Santos-Silva AR,Lopes MA,Capistrano HM,Coletta RD,Fonseca FP

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:Secretory leukocyte proteinase inhibitor (SLPI) is an endogenous mucosa associated protein that has been proposed to possess anti-human immunodeficiency virus type 1 (HIV-1) activity. The aim of this study was to investigate the biological function of SLPI in salivary mediated inhibition of HIV infection and ...

journal_title：Oral diseases

authors： Skott P,Lucht E,Ehnlund M,Björling E

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms underlying the development of dysplasia in leukoplakia are unknown. We used RNA sequencing to examine the molecular and biological pathway differences in oral leukoplakia with and without oral epithelial dysplasia. MATERIALS AND METHODS:Excisional biopsy specimens (25) were taken fro...

journal_title：Oral diseases

authors： Farah CS,Fox SA

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:To assess the health-related quality of life (HRQOL) of patients complaining of halitosis at their first visit and at a later time when their complaint had diminished following therapy, using a self-administered questionnaire, the Medical Outcome Study Short Form-36 (SF-36). The aim of this study was to exami...

journal_title：Oral diseases

authors： Kishi M,Abe A,Yonemitsu M

更新日期：2005-01-01 00:00:00

abstract：:Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. C...

journal_title：Oral diseases

authors： Liu C,Qi X,Yang D,Neely A,Zhou Z

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To explore the role of CD10 in cisplatin resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). METHODS:The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplati...

journal_title：Oral diseases

authors： Wang Y,Li Q,Xu L,Chen J,Pu Y,Wang L,Sun H,Guo Y,Guo C

更新日期：2020-10-09 00:00:00

abstract：OBJECTIVES:To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan. METHODS:A total of 34 136 men and 43 711 women aged 40-79 years were included in the study. The Cox proportional ...

journal_title：Oral diseases

authors： Ide R,Mizoue T,Fujino Y,Hoshiyama Y,Sakata K,Tamakoshi A,Yoshimura T,JACC Study Group.

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVES:Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS:Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg k...

journal_title：Oral diseases

authors： de Barros Silva PG,de Oliveira CC,Brizeno L,Wong D,Lima Júnior R,Gonçalves RP,Sousa FB,Mota M,de Albuquerque Ribeiro R,Alves A

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVES:It was hypothesized that beta 2 defensin (BD-2) is increased in RAU lesions compared with healthy controls to promote anti-microbial host defence. METHODS:RAU and control mucosa samples were subjected to quantitative real-time PCR and immunostained for BD-2, CD68, mast cell tryptase and 4-hydroxynonenal (4H...

journal_title：Oral diseases

authors： Al-Samadi A,Salem A,Ainola M,Hietanen J,Häyrinen-Immonen R,Konttinen YT

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine the correlation between the number of FOXP3(+) T cell in lesions and the disease activity of patients with oral lichen planus (OLP). MATERIALS AND METHODS:The expression of FOXP3 was investigated using immunohistochemical staining and real-time RT-PCR in 23 OLP lesions ...

journal_title：Oral diseases

authors： Tao XA,Xia J,Chen XB,Wang H,Dai YH,Rhodus NL,Cheng B

更新日期：2010-01-01 00:00:00

abstract：:Submandibular gland excision is generally performed through a transcervical approach, a safe procedure that, however, carries few neurological, functional and aesthetic drawbacks. Intraoral approach to the submandibular gland has been described many years ago but it has been newly proposed in recent years thanks to en...

journal_title：Oral diseases

authors： Cammaroto G,Vicini C,Montevecchi F,Bonsembiante A,Meccariello G,Bresciani L,Pelucchi S,Capaccio P

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Periodontitis is a chronic inflammatory disease of the tissues supporting the teeth and is caused by subgingival plaque. Systemic increases in reactive oxygen species are involved in pathogenesis of periodontitis. This study addressed the relationship between levels of serum oxidative stress and antibodies ag...

journal_title：Oral diseases

authors： Tamaki N,Hayashida H,Fukui M,Kitamura M,Kawasaki K,Nakazato M,Maeda T,Saito T,Ito HO

更新日期：2014-04-01 00:00:00

abstract：:HIV infection and AIDS are spreading rapidly among the world's children, especially among African-American and Hispanic children in the USA, and those in developing countries. Although recent research has identified several ways of preventing perinatal transmission of HIV, most of these methods are too expensive for w...

journal_title：Oral diseases

authors： Ramos-Gomez F

更新日期：2002-01-01 00:00:00