Abstract:
OBJECTIVE:To explore the role of CD10 in cisplatin resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). METHODS:The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplatin treatment. Genes related to chemotherapy resistance, cancer stem cells and the epithelial-mesenchymal transition were detected by quantitative real-time PCR (qPCR) in CD10high and CD10low OSCC cells. Mouse xenograft model and venous metastasis model were used to explore the potential regulatory mechanism of the resistance effect of CD10 on cisplatin. RESULTS:The higher expression of CD10 gene in different cell lines displayed enhanced cisplatin resistance ability. The expression of genes related to chemotherapy resistance, cell stemness, and the epithelial-mesenchymal transition was significantly higher in CD10high cells compared with CD10low cells. Moreover, the combination of cisplatin and Hh pathway inhibitors significantly reduced the resistance of CD10 to cisplatin in the xenograft model and venous metastasis models. CONCLUSION:CD10-positive cells are implicated in developing cisplatin resistance of OSCC, which could be related to its cancer stem cell characteristics regulated by the Hedgehog pathway.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Wang Y,Li Q,Xu L,Chen J,Pu Y,Wang L,Sun H,Guo Y,Guo Cdoi
10.1111/odi.13673subject
Has Abstractpub_date
2020-10-09 00:00:00eissn
1354-523Xissn
1601-0825pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract:OBJECTIVE:Placenta growth factor (PlGF) is associated with the progression and prognosis of oral cancer. MATERIALS AND METHODS:This study used ELISA, quantitative polymerase chain reaction, and Western blotting to study the arecoline-stimulated (PlGF) protein or mRNA expression in human gingival epithelial S-G cells. ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12034
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To generate a nomogram for predicting the risk of neck node metastasis in pathologically node-negative patients using a combination of variables comprising of protein expression, ultrastructural alterations and clinicopathological parameters. MATERIALS AND METHODS:Surgically removed oral tumours (n = 103) we...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12696
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro. MATERIALS AND METHODS:Ninety-six dentin samples were prepared from 24 freshl...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.01762.x
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To investigate the association of miR-499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC. METHODS:The genotyping of miR-499a T>C (rs3746444) using TagMan assay was conducted in two case-cont...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12241
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:The imbalanced host response in front of a dysbiotic biofilm is one of the major aspects of severe periodontitis, which also presents a strong familial aggregation related to the susceptibility factors transmission within family members. This study hypothesized that aggressive periodontitis (GAgP) patients a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13738
更新日期:2020-11-30 00:00:00
abstract:OBJECTIVES:The early diagnosis and monitoring of Crohn's disease (CD) and orofacial granulomatosis (OFG) might be facilitated by assaying potential disease biomarkers in saliva. Markers of oxidative stress and inflammation were assayed in salivas from patients with CD, OFG and concurrent OFG and CD (OFG + CD). SUBJECT...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13537
更新日期:2021-03-01 00:00:00
abstract:OBJECTIVE:Inflammatory papillary hyperplasia of the palate (IPHP) or the granular type of denture stomatitis, is a non-neoplastic lesion characterized histologically by a significant epithelial hyperplasia and inflammatory infiltrate usually caused by trauma and Candida infection. p53 and proliferative cell nuclear ant...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1998.tb00278.x
更新日期:1998-09-01 00:00:00
abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13598
更新日期:2020-08-09 00:00:00
abstract:BACKGROUND:Tobacco-related oral squamous cell carcinoma (OSCC) is one of the most common cancers involving Indian males. We assessed the association of IL4 promoter -589 T>C, -33 T>C, and IL6-174 G>C functional genetic polymorphisms with tobacco-related OSCC in Asian Indians. PATIENTS AND METHODS:The IL4 and IL6 promo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2011.01831.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN:Retrospective case review. METHODS:The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2008.01494.x
更新日期:2009-01-01 00:00:00
abstract::HIV infection remains a global health problem of unprecedented dimensions, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable chronic disease with longer survival and improved quality of life in HIV-infected subjects. Among th...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2010.01727.x
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:This systematic review was to evaluate the change of oral microbiome based on next-generation sequencing (NGS)-metagenomic analysis following periodontal interventions among systematically healthy subjects. MATERIALS AND METHODS:A structured search strategy consisting of "metagenomics" and "oral diseases" w...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13405
更新日期:2020-05-11 00:00:00
abstract::The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12472
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13420
更新日期:2020-10-01 00:00:00
abstract::The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by rela...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2010.01765.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:The management of the COVID-19 outbreak occurred in Lombardy (Italy) implied that non-COVID-19 health care was remodeled, limiting adequate resources in non-hospital public dental healthcare settings. This situation offered the opportunity to investigate the occupational COVID-19 risk to dental staff in publi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13632
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:The purposes of this study were to assess the influence of age on oral squamous cell carcinoma patients and sought to analyze the reasons that may contribute to this difference. METHODS:This study enrolled 2,782 patients included 2,443 patients in a retrospective cohort to find the influence of age and 339 ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13015
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVES:To analyze the role of patient compliance as a factor in evaluating the effectiveness of continuous sialogogues to prevent salivary side effects from 131 I therapy in differentiated thyroid cancer patients. METHODS:Differentiated thyroid cancer patients who were clinically scheduled for an 131 I therapy at ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12969
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To compare the effects of sodium lauryl sulfate (SLS)-free and SLS-containing dentifrice in patient with recurrent aphthous stomatitis (RAS). MATERIALS AND METHODS:The design of this study was a double-blind crossover trial. The 90 subjects were divided into three groups: group I used SLS-free (a commerciall...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1601-0825.2012.01920.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP). METHODS:Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12073
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Head and neck squamous cell carcinoma (HNSCC) progression and metastasis have previously been associated with the activation of phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) and Wnt signalling pathways, which lead to the activation of pro-proliferative genes, such as cyclin D1. The current study a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12124
更新日期:2014-04-01 00:00:00
abstract::DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Of the all epigenetic modifications, methylation, which represses transcription of the promoter region of tumor suppressor genes leading to gene silencing, ha...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2011.01833.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of EBV-DNA, CMV-DNA and HPV-DNA in oral healthy mucosa of HIV-infected and renal transplant patients. To associate the detection of viral genomes with laboratory parameters of immunodeficiency, gender, antiretroviral and immunosuppressive therapy. DESIGN:A cross-sectional analysi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1997.tb00361.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:Radicular cysts occur as a result of the immunological response to continuous antigenic stimulation from root canals. We correlated the immunophenotypical composition of the lymphoid infiltrate to the microvessel density expressed by the count of CD34 reactive endothelial cells in radicular cysts. SUBJECTS A...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2012.01961.x
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01414.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:In this study, we aimed to clarify the precise mechanism underlying lipopolysaccharide (LPS)-induced osteoclastogenesis in periodontal disease with a special reference to double-stranded RNA-dependent protein kinase (PKR). MATERIAL AND METHODS:We dissected the role of PKR in LPS-induced osteoclast differenti...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12592
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Candida-induced denture stomatitis is a common debilitating problem among denture wearers. Previously, we described the fabrication of a new denture material that released antifungal drugs when immersed in phosphate buffered saline. Here, we use more clinically relevant immersion conditions (human saliva; 37°...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12456
更新日期:2016-07-01 00:00:00
abstract::The connective tissues of the gingiva and periodontal ligament share a common embryonic development from cells of the cranial neural crest. This review paper describes the relationship of these tissues in tooth germ initiation, development and eruption. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1995.tb00188.x
更新日期:1995-12-01 00:00:00
abstract:OBJECTIVES:To investigate practices and opinions of general dentists in Maryland, USA, related to oral and pharyngeal cancer prevention and early detection. DESIGN AND METHODS:A pre-tested, 34-item questionnaire, cover letter and addressed, stamped envelope were mailed in the summer, 1995, to a simple random sample of...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2000.tb00140.x
更新日期:2000-09-01 00:00:00