Abstract:
OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on formation of smooth surface and sulcal caries in cariogenically challenged rats infected with Streptococcus sobrinus. METHODS:Weanling rats, inoculated with S. sobrinus, were randomly assigned to six groups which were topically treated twice daily with water (treatment control), a NaF solution of 100 parts/10(6) F (positive control), or AIK(SO4)2 solutions containing 100, 1000, 2000, or 4000 parts/10(6) AI. Rats were fed a high-sucrose diet and distilled water ad libitum for 10 weeks, then the molars were scored for enamel and dentin caries. RESULTS:Relative to the water control, NaF and all AI solutions significantly reduced prevalence of both smooth-surface and fissure caries. Protection by AI solutions was greater on smooth surfaces than sulcal areas. AI treatments reduced smooth surface scores by 49-71% and sulcal scores by 27-53%. For all comparisons the protective effect of the 100 parts/10(6) AI solution was less than solutions containing 1000 parts/10(6) AI or more. NaF and all AI solutions also significantly reduced the extent of lesions penetration into dentin. CONCLUSIONS:Topically applied AI reduced the formation and progression of both smooth surface and sulcal caries and showed evidence of a dose response in a rat model infected with S. sobrinus.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Putt MS,Kleber CJdoi
10.1111/j.1601-0825.1995.tb00164.xsubject
Has Abstractpub_date
1995-06-01 00:00:00pages
80-5issue
2eissn
1354-523Xissn
1601-0825journal_volume
1pub_type
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