Abstract:
OBJECTIVE:This study was designed to establish a rat model of a critical size alveolar bone defect. MATERIALS AND METHODS:Standardized buccal or mesiobuccal alveolar bone defects were made around the right first mandibular molar of 12-week-old rats, and the left was used as a control. Alveolar bone healing was examined quantitatively by three-dimensional micro-computed tomographic imaging. Bone matrix production of osteoblasts and osteocytes during repair of alveolar bone defects was examined with in situ hybridization for type I collagen. RESULTS:Buccal defects were repaired significantly and the volume decreased by 88.3% in week 24, whereas mesiobuccal defects were repaired little. Osteoblasts and osteocytes expressed type I collagen in both defects in week 3 but showed little expression by week 6 and thereafter, leaving the mesiobuccal defects largely unrepaired. CONCLUSION:The mesiobuccal defect is a critical-size defect that is not ultimately repaired with bone. It may be an appropriate experimental model for investigating the effectiveness of bone regenerative agents in human alveolar bone loss.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Ebina H,Hatakeyama J,Onodera M,Honma T,Kamakura S,Shimauchi H,Sasano Ydoi
10.1111/j.1601-0825.2009.01522.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
273-80issue
4eissn
1354-523Xissn
1601-0825pii
ODI1522journal_volume
15pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract:AIM:The objective of this study was to investigate the effects of bisphosphonate on the mandible of rats in the growing phase with steroid-induced osteoporosis, and to estimate the biomechanical response in the mandibular bone. MATERIALS AND METHODS:Eight-week-old male Wistar rats (n = 50) were assigned to a 6-week co...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01331.x
更新日期:2007-11-01 00:00:00
abstract::Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure t...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2008.01441.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVES:YouTube™ has become a widely used source of health information. This cross-sectional study aimed to analyze the quality of English language videos on oral leukoplakia available on YouTube™. MATERIALS AND METHODS:A YouTube™ search for oral leukoplakia was performed, leading to 1,690 videos. The first 100 res...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13161
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Osteoblast apoptosis is critical for the development and repairing of bone destruction in persistent apical periodontitis (PAP). Enterococcus faecalis is considered as a frequently isolated pathogen of PAP. This study aimed to explore the effect of E. faecalis on apoptosis in osteoblastic MC3T3-E1 cells via a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12883
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the levels, molecular forms and activation degree of matrix metalloproteinase-13 (MMP-13) in the gingival crevicular fluid (GCF) of patients with periodontal diseases and to correlate these findings with periodontal clinical parameters. METHODS:Sixty one subjects pa...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01244.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:We evaluated the prevalence of hepatitis virus infection in a large population of patients in terms of diseases requiring oral surgery. DESIGN:Retrospective case survey. SUBJECTS AND METHODS:Prevalence of hepatitis B and C virus (HBV, HCV) infection were compared between oral diseases such as inflammation, ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.1o794.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To investigate the sex differences in clinical features, including salivary flow rate, psychological distress and hypothalamic-pituitary-adrenal axis response and their inter-relationships in patients with burning mouth syndrome. SUBJECTS AND METHODS:Eighteen men and 37 postmenopausal women with burning mout...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13195
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To obtain baseline data on angular cheilitis in Southern Chinese. DESIGN:A cross-sectional investigation of the clinical, microbiological and ultrastructural features of the condition. SUBJECTS AND METHOD:Thirty six Chinese adults with angular cheilitis; 28 controls matched for age and sex, with no inflamma...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1995.tb00156.x
更新日期:1995-03-01 00:00:00
abstract::Proliferative verrucous leukoplakia (PVL) is of uncertain etiology but may be associated with human papillomavirus (HPV) infection. Proliferative verrucous leukoplakia is seen mainly in older women, beginning as a simple slow-growing, persistent leukoplakia that tends to spread and become multifocal and affect the gin...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2009.01632.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the oral functionality and the oral sensorimotor alterations are associated with oropharyngeal dysphagia in community-dwelling older persons and long-term care older residents. METHODS:An exploratory study with 265 independent older persons of the southern state of Brazil. The diagnosis o...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12809
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:For clinical applications of biomarkers, there is a need for multiplex assays using high throughput platforms. The objective of this study was to determine the efficacy of Luminex Multianalyte Profiling (xMAP) technology for measurement of salivary proteins and to evaluate whether multiplex assays are as effe...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2008.01488.x
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. METHODS:Databases including Ovid MEDLINE, ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13671
更新日期:2020-10-08 00:00:00
abstract:OBJECTIVE:In this study, we aimed to clarify the precise mechanism underlying lipopolysaccharide (LPS)-induced osteoclastogenesis in periodontal disease with a special reference to double-stranded RNA-dependent protein kinase (PKR). MATERIAL AND METHODS:We dissected the role of PKR in LPS-induced osteoclast differenti...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12592
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the cysteine protease inhibitory properties of the human salivary cystatins S, SA and SN in order to identify potential in vivo target cysteine proteases which may include those involved in periodontal tissue destruction. In addition, the potential role of the salivar...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1999.tb00307.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to examine the prevalence of selected periodontal pathogens associated with HIV and non-HIV related periodontal lesions. METHODS:Subgingival plaque samples were obtained from both HIV-seropositive and HIV-seronegative patients affected with periodontal disease. DNA probes were used t...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00350.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To study the response to in vitro priming of peripheral neutrophils from patients with periodontitis compared to healthy controls. Peripheral neutrophils from these patients had shown increased production of oxygen radicals after activation with opsonized bacteria and a difference in priming response could s...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00030.x
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To compare counts of Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis and Fusobacterium nucleatum between crack users and non-users. MATERIALS AND METHODS:A cross-sectional study was conducted involving seventy-four crack cocaine users and eighty-one non-users matched fo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12609
更新日期:2017-04-01 00:00:00
abstract::In order for chairside diagnostic testing to make an impact on dental therapy, practitioners require a better understanding of genetic mutations contributing to the pathophysiology of periodontal disease. Commensal and pathogenic bacterial colonization in oral cavity tissues produces a cascade of proinflammatory signa...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13030
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13598
更新日期:2020-08-09 00:00:00
abstract:OBJECTIVE:This article sets out to evaluate the prevalence and aetiopathogenesis of edentulism in patients on haemodialysis. SUBJECTS AND METHODS:The study group comprised 44 adult patients with end-stage renal disease (ESRD) on haemodialysis. A control group was formed of 44 individuals matched for age and sex and wi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12486
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVES:To determine expression and localization of membrane-associated mucins within human keratinized and non-keratinized oral epithelia, and to explore transcriptional changes associated with primary Sjögren's syndrome. SUBJECTS AND METHODS:Mucin transcripts and glycoproteins were determined by RT-PCR and immuno...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13098
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12552
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Orofacial clefts (OFCs) are common birth defects that may impose a large burden on the health and psychosocioeconomic well-being of affected individuals and families. This study aims to identify qualitative factors that affect the quality of life (QOL) of family caregivers of children with OFCs. METHODS:A m...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12379
更新日期:2016-03-01 00:00:00
abstract:OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13056
更新日期:2019-05-01 00:00:00
abstract::Currently, 4 novel Direct Oral Anticoagulants (DOACs) were approved by the FDA. This review focuses on these agents and proposes a matrix for the general dentists to assess bleeding risk in dental management of patient on DOACs. The outline covers the pharmacology of DOACs (rivaroxaban, apixaban, edoxaban and dabigatr...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12371
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The aims of this study were to investigate the prevalence of sleep bruxism in children in Japan, and its relationships with sleep-related factors and daytime problematic behavior. SUBJECTS AND METHODS:Guardians of 6023 children aged 2-12 years completed the Japanese Sleep Questionnaire. Multiple regression ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12492
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01183.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus. Therefore, we developed novel species-specific oligonucleotide probes to accurately speciate seven pathogenic...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.02926.x
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a bi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01433.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To assess the effect of adjunctive use of modified cold-atmospheric pressure plasma (MCAP) to surgically mechanical debridement (MD) on peri-implantitis (PI) in beagles. MATERIAL AND METHODS:Bilateral mandibles of beagles with PI, which induced by cotton ligature twined with steel in sub-marginal around the ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13757
更新日期:2020-12-15 00:00:00