Palatal zygomycosis: experience of 21 cases.

Abstract:

OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a biopsy of the palatal lesion and autopsy. This study reports the treatment experience with amphotericin B alone and in combination with itraconazole and fluconazole. RESULTS:Twenty-one cases (18.75%) of zygomycosis with palatal involvement were included in the study, from a total of 112 cases screened. Mean age was 36.5 years, with 18 adults and three children. The associated pre-disposing factors were: ketoacidotic diabetes (five type-1 and 15 type-2), and acute leukaemia in one patient. The clinical varieties were as follows: 19 cases of rhinocerebral (RC) involvement and two disseminated cases. Palatal ulcers occurred in 3/21 early cases (14.3%) and in 16/21 cases after the nasal involvement. All patients received amphotericin B; in four patients, it was combined with itraconazole and four with fluconazole. Clinical and mycological cure was achieved in 4/21 patients (19.04%). CONCLUSION:Zygomycosis with palatal involvement occurs in around 18% of cases, usually associated with RC modalities; it has an acute and generally lethal course.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Bonifaz A,Macias B,Paredes-Farrera F,Arias P,Ponce RM,Araiza J

doi

10.1111/j.1601-0825.2007.01433.x

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

569-74

issue

6

eissn

1354-523X

issn

1601-0825

pii

ODI1433

journal_volume

14

pub_type

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