Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer.

Abstract:

AIM:To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. PATIENTS AND METHODS:A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers for progression-free survival (PFS) and overall survival (OS). Logistic models were used to assess the association with downstage in TNM 8th ed. RESULTS:Seventy-seven (61.6%) pts had HPV/p16 + related OPC. Therapeutic choice consisted in sequential and concurrent CRT. Median follow-up was 50 months. A value of NLR ≥3 was associated with poorer OS. Two-year OS was 91% and 81% in pts with NLR <3 and ≥3, respectively. CONCLUSION:A baseline NLR ≥ 3 at treatment initiation represented a negative prognostic marker for OPC treated with definitive CRT. These results are in line with literature data, and prognostic value of NLR has been confirmed restaging our cohort with new TNM staging (8th ed.). Therefore, NLR could be considered a valuable biomarker for risk stratification in pts with OPC.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Fanetti G,Alterio D,Marvaso G,Gandini S,Rojas DP,Gobitti C,Minatel E,Revelant A,Caroli A,Francia CM,Alessandro O,Pepa M,Gugliandolo SG,Starzyńska A,Polesel J,Vaccher E,Cossu Rocca M,Tagliabue M,Ansarin M,Lupato V,

doi

10.1111/odi.13366

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

1384-1392

issue

7

eissn

1354-523X

issn

1601-0825

journal_volume

26

pub_type

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