Abstract:
OBJECTIVE:To assess whether a relationship existed between the T102C polymorphism of 5-HT2A receptor gene and temporomandibular dysfunction. METHODS:Sixty-three patients with temporomandibular dysfunction, and 54 healthy volunteer controls were included in the study. Molecular analysis of the T102C polymorphism of the 5-HT2A receptor gene was performed using PCR technique. RESULTS:The C/C genotype was over represented in the patients whereas T/T genotype was over represented in the controls (P < 0.05). The genotype distribution of the patients who had temporomandibular dysfunction was not different than those who did not have temporomandibular dysfunction (P > 0.05). CONCLUSION:The T102C polymorphism may be involved in the etiology of temporomandibular dysfunction. The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Mutlu N,Erdal ME,Herken H,Oz G,Bayazit YAdoi
10.1111/j.1601-0825.2004.01037.xsubject
Has Abstractpub_date
2004-11-01 00:00:00pages
349-52issue
6eissn
1354-523Xissn
1601-0825pii
ODI1037journal_volume
10pub_type
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