Abstract:
BACKGROUND:Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expression is correlated with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS:The clinical features of 102 patients with OSCC of the tongue treated in a single institution were obtained from the medical records and all histopathological diagnoses were reviewed. The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors. RESULTS:Eighty-one cases (79.41%) were positive for FAS. Microscopic characteristics such as histological grade (P < 0.05), lymphatic permeation (P < 0.001), perineural infiltration (P < 0.05), and nodal metastasis (P < 0.02) were associated with FAS status. A significantly lower survival probability for patients with advanced clinical stage (log-rank test, P < 0.001), lymph nodes metastasis (log-rank test, P < 0.001), presence of vascular permeation (log-rank test, P = 0.05), and perineural invasion (log-rank test, P = 0.01) was observed in the studied samples. CONCLUSION:The expression of FAS in OSCC of the tongue is associated with the microscopic characteristics that determine disease progression and prognosis.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Silva SD,Perez DE,Nishimoto IN,Alves FA,Pinto CA,Kowalski LP,Graner Edoi
10.1111/j.1601-0825.2007.01395.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
376-82issue
4eissn
1354-523Xissn
1601-0825pii
ODI1395journal_volume
14pub_type
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