Autophagy inhibits TLR4-mediated invasiveness of oral cancer cells via the NF-κB pathway.

Abstract:

OBJECTIVES:Toll-like receptor 4 (TLR4) is abnormally expressed in oral cancer tissues and promotes cancer cell invasion. The purpose of this study was to clarify the mechanism by which autophagy regulates oral cancer invasion through the TLR4-NF-κB pathway. SUBJECTS AND METHODS:We examined TLR4 expression in oral cancer tissues and analysed the relationship between its expression and clinicopathological features. The invasion and migration of LPS-stimulated oral cancer cells with up- or downregulation of TLR4 expression was detected in addition to NF-κB signalling and autophagy levels. Furthermore, the role of autophagy in regulating TLR4-mediated cell invasiveness was explored by silencing the expression of key autophagy genes ATG7 and p62. RESULTS:We found that TLR4 overexpression was closely related to cervical lymphatic metastasis and poor survival. TLR4 activated the NF-κB pathway to promote the invasiveness of OSCC cells, and autophagy partly inhibited invasiveness by suppressing the NF-κB pathway. We observed that p62 translocated from the cytoplasm to the nucleus when autophagy was activated by LPS. Finally, silencing p62 further promoted LPS-mediated cell invasiveness. CONCLUSION:Toll-like receptor 4 significantly enhanced the invasiveness of OSCC cells. Autophagy may regulate cell invasiveness through the NF-κB pathway by modulating both the cytoplasmic and nuclear levels of p62.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Kong Q,Liang Y,He Q,You Y,Wu L,Liang L,Liang J

doi

10.1111/odi.13355

subject

Has Abstract

pub_date

2020-04-14 00:00:00

eissn

1354-523X

issn

1601-0825

pub_type

杂志文章
  • Sex hormone replacement therapy in periodontology-A systematic review.

    abstract:OBJECTIVE:To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. MATERIALS AND METHODS:Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/MEDLINE. Human observational and intervent...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13059

    authors: Chaves JDP,Figueredo TFM,Warnavin SVSC,Pannuti CM,Steffens JP

    更新日期:2020-03-01 00:00:00

  • The effect of commercially available saliva substitutes on predemineralized bovine dentin in vitro.

    abstract:OBJECTIVE:The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro. MATERIALS AND METHODS:Ninety-six dentin samples were prepared from 24 freshl...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2002.01762.x

    authors: Meyer-Lueckel H,Schulte-Mönting J,Kielbassa AM

    更新日期:2002-07-01 00:00:00

  • Effect of aluminum concentration on dental caries formation in the rat.

    abstract:OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on fo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1995.tb00164.x

    authors: Putt MS,Kleber CJ

    更新日期:1995-06-01 00:00:00

  • The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy.

    abstract:OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01183.x

    authors: Bots CP,Poorterman JH,Brand HS,Kalsbeek H,van Amerongen BM,Veerman EC,Nieuw Amerongen AV

    更新日期:2006-03-01 00:00:00

  • Diagnostic profiling of salivary exosomal microRNAs in oral lichen planus patients.

    abstract:OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12374

    authors: Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

    更新日期:2015-11-01 00:00:00

  • Alpha-lipoic acid treatment of 31 patients with sore, burning mouth.

    abstract:OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01414.x

    authors: Steele JC,Bruce AJ,Drage LA,Rogers RS 3rd

    更新日期:2008-09-01 00:00:00

  • Effect of sodium lauryl sulfate on recurrent aphthous stomatitis: a randomized controlled clinical trial.

    abstract:OBJECTIVE:To compare the effects of sodium lauryl sulfate (SLS)-free and SLS-containing dentifrice in patient with recurrent aphthous stomatitis (RAS). MATERIALS AND METHODS:The design of this study was a double-blind crossover trial. The 90 subjects were divided into three groups: group I used SLS-free (a commerciall...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2012.01920.x

    authors: Shim YJ,Choi JH,Ahn HJ,Kwon JS

    更新日期:2012-10-01 00:00:00

  • Antibiotic effects on bacterial profile in osteonecrosis of the jaw.

    abstract:OBJECTIVE:Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. MATERIALS ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2011.01848.x

    authors: Ji X,Pushalkar S,Li Y,Glickman R,Fleisher K,Saxena D

    更新日期:2012-01-01 00:00:00

  • Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone.

    abstract:OBJECTIVES:Salivary glands are useful targets for gene therapeutics. After gene transfer into salivary glands, regulated secretory pathway proteins, such as human growth hormone, are secreted into saliva, whereas constitutive secretory pathway proteins, such as erythropoietin, are secreted into the bloodstream. Secreti...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12217

    authors: Racz GZ,Zheng C,Goldsmith CM,Baum BJ,Cawley NX

    更新日期:2015-03-01 00:00:00

  • Occupational COVID-19 risk to dental staff working in a public dental unit in the outbreak epicenter.

    abstract:OBJECTIVE:The management of the COVID-19 outbreak occurred in Lombardy (Italy) implied that non-COVID-19 health care was remodeled, limiting adequate resources in non-hospital public dental healthcare settings. This situation offered the opportunity to investigate the occupational COVID-19 risk to dental staff in publi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13632

    authors: Nardone M,Cordone A,Petti S

    更新日期:2020-09-03 00:00:00

  • Marathon of eponyms: 6 Frey syndrome (Gustatory sweating).

    abstract::The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry,...

    journal_title:Oral diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01538.x

    authors: Scully C,Langdon J,Evans J

    更新日期:2009-11-01 00:00:00

  • Bone-site-specific responses to zoledronic acid.

    abstract:OBJECTIVES:Bisphosphonates are widely used to treat bone diseases such as osteoporosis. However, they may cause osteonecrosis of the jaw. Here, we investigated whether in vivo exposure to bisphosphonates has a different effect on long bone and jaw osteoclasts, and on the turnover of these different bones. MATERIALS AN...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12587

    authors: Vermeer J,Renders G,van Duin MA,Jansen I,Bakker LF,Kroon SA,de Vries TJ,Everts V

    更新日期:2017-01-01 00:00:00

  • The soft connective tissues of the gingiva and periodontal ligament: are they unique?

    abstract::The connective tissues of the gingiva and periodontal ligament share a common embryonic development from cells of the cranial neural crest. This review paper describes the relationship of these tissues in tooth germ initiation, development and eruption. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1995.tb00188.x

    authors: Palmer RM,Lubbock MJ

    更新日期:1995-12-01 00:00:00

  • Oral adverse effects of drugs: Taste disorders.

    abstract:OBJECTIVE:Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision ma...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13199

    authors: Rademacher WMH,Aziz Y,Hielema A,Cheung KC,de Lange J,Vissink A,Rozema FR

    更新日期:2020-01-01 00:00:00

  • Patient-derived xenografts of a case of ameloblastic fibrodentinoma.

    abstract:OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13056

    authors: Pereira NB,de Souza JC,Bastos VC,Fonseca FP,de Avelar GF,Castro WH,Dias AAM,Mosqueda-Taylor A,Gomez RS,Gomes CC

    更新日期:2019-05-01 00:00:00

  • Orofacial granulomatosis--a 20-year review.

    abstract::Orofacial granulomatosis (OFG) is the presence of persistent enlargement of the soft tissues of the oral and maxillofacial region, characterized by non-caseating granulomatous inflammation in the absence of diagnosable systemic Crohn's disease (CD) or sarcoidosis. Over 20 years have passed since OFG was first describe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01500.x

    authors: Grave B,McCullough M,Wiesenfeld D

    更新日期:2009-01-01 00:00:00

  • Salivary proteomics in lichen planus: A relationship with pathogenesis?

    abstract:OBJECTIVES:Oral lichen planus is a chronic, T-cell-mediated, inflammatory disease that affects the oral cavity. The oral lichen planus pathogenesis is still unclear, however, the main evidence is that the mechanisms of activation of different T lymphocyte pathway induce apoptosis with an increase in Th1 and Th17 subtyp...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12837

    authors: Souza MM,Florezi GP,Nico M,de Paula F,Paula FM,Lourenço SV

    更新日期:2018-07-01 00:00:00

  • Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO Collaborating Centre for Oral Cancer.

    abstract::Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13704

    authors: Warnakulasuriya S,Kujan O,Aguirre-Urizar JM,Bagan JV,González-Moles MÁ,Kerr AR,Lodi G,Mello FW,Monteiro L,Ogden GR,Sloan P,Johnson NW

    更新日期:2020-10-31 00:00:00

  • The deep mycoses in HIV infection.

    abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00361.x

    authors: Scully C,de Almeida OP,Sposto MR

    更新日期:1997-05-01 00:00:00

  • Comparative effects of various commercially available mouthrinse formulations on oral malodor.

    abstract:OBJECTIVES:The primary aim of this study was to compare a new mouthwash (SB12®) containing 0.025% chlorhexidine and 0.3% zinc for oral malodor reduction against four commercially available mouthwashes and negative control. A secondary aim was to compare the two methods for measuring volatile sulphur compounds (VSC) by ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2010.01714.x

    authors: Saad S,Greenman J,Shaw H

    更新日期:2011-03-01 00:00:00

  • The dynamics of the oral microbiome and oral health among patients receiving clear aligner orthodontic treatment.

    abstract:OBJECTIVES:This 6-month prospective clinical study assessed the impacts of Invisalign appliances on the oral bacterial community and oral health of patients. METHODS:Salivary samples were obtained from twenty-five adult patients receiving Invisalign aligner treatment before the treatment (Group B) and at a 6-month fol...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13175

    authors: Zhao R,Huang R,Long H,Li Y,Gao M,Lai W

    更新日期:2020-03-01 00:00:00

  • Effect of in vitro aging on Campylobacter rectus lipopolysaccharide-stimulated PGE2 release from human gingival fibroblasts.

    abstract:OBJECTIVE:We examined the influence of in vitro aging on Campylobacter rectus (C. rectus) lipopolysaccharide (LPS)-stimulated prostaglandin (PG), E2 release frOm human gingival fibroblasts (HGFs). MATERIALS AND METHODS:LPS was prepared from C. rectus ATCC33238. HGFs were established from healing gingival tissue remove...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1996.tb00225.x

    authors: Takiguchi H,Yamaguchi M,Mochizuki K,Abiko Y

    更新日期:1996-09-01 00:00:00

  • Relationship between the SF-36 questionnaire and patient's satisfaction following halitosis therapy.

    abstract:OBJECTIVE:To assess the health-related quality of life (HRQOL) of patients complaining of halitosis at their first visit and at a later time when their complaint had diminished following therapy, using a self-administered questionnaire, the Medical Outcome Study Short Form-36 (SF-36). The aim of this study was to exami...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01102.x

    authors: Kishi M,Abe A,Yonemitsu M

    更新日期:2005-01-01 00:00:00

  • Immune cellular profile of bisphosphonate-related osteonecrosis of the jaw.

    abstract:OBJECTIVES:Characterize the cell profile and immunostaining of proinflammatory markers in an experimental model of bisphosphonate-related osteonecrosis of the jaw (BRONJ). MATERIALS AND METHODS:Male Wistar rats (n = 6-7) were treated chronically with saline solution or zoledronic acid (ZA) at 0.04, 0.20, and 1.00 mg k...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12513

    authors: de Barros Silva PG,de Oliveira CC,Brizeno L,Wong D,Lima Júnior R,Gonçalves RP,Sousa FB,Mota M,de Albuquerque Ribeiro R,Alves A

    更新日期:2016-10-01 00:00:00

  • The association between miR-499a polymorphism and oral squamous cell carcinoma progression.

    abstract:OBJECTIVE:To investigate the association of miR-499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC. METHODS:The genotyping of miR-499a T>C (rs3746444) using TagMan assay was conducted in two case-cont...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12241

    authors: Hou YY,Lee JH,Chen HC,Yang CM,Huang SJ,Liou HH,Chi CC,Tsai KW,Ger LP

    更新日期:2015-03-01 00:00:00

  • Development of novel oligonucleotide probes for seven Actinomyces species and their utility in supragingival plaque analysis.

    abstract:OBJECTIVE:The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus. Therefore, we developed novel species-specific oligonucleotide probes to accurately speciate seven pathogenic...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.02926.x

    authors: Tang G,Yip HK,Luo G,Cheung BP,Shen S,Samaranayake LP

    更新日期:2003-07-01 00:00:00

  • Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.

    abstract:OBJECTIVES:To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. SUBJECTS AND METHODS:Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13337

    authors: Penteado CAS,Batista TBD,Chaiben CL,Bonacin BG,Ventura TMO,Dionizio A,Couto Souza PH,Buzalaf MAR,Azevedo-Alanis LR

    更新日期:2020-04-01 00:00:00

  • Early tooth loss in end-stage renal disease patients on haemodialysis.

    abstract:OBJECTIVE:This article sets out to evaluate the prevalence and aetiopathogenesis of edentulism in patients on haemodialysis. SUBJECTS AND METHODS:The study group comprised 44 adult patients with end-stage renal disease (ESRD) on haemodialysis. A control group was formed of 44 individuals matched for age and sex and wi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12486

    authors: Limeres J,Garcez JF,Marinho JS,Loureiro A,Diniz M,Diz P

    更新日期:2016-09-01 00:00:00

  • Trigeminal autonomic cephalalgias.

    abstract::The trigeminal autonomic cephalalgias (TACs) are a group of primary headache disorders characterised by lateralized symptoms: prominent headache and ipsilateral cranial autonomic features, such as conjunctival injection, lacrimation and rhinorrhea. The TACs are: cluster headache (CH), paroxysmal hemicrania (PH), short...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12263

    authors: Eller M,Goadsby PJ

    更新日期:2016-01-01 00:00:00

  • Periodontal disease: associations with diabetes, glycemic control and complications.

    abstract:OBJECTIVE:This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes. DESIGN:MEDLINE search of the English language literature identified primary research reports published on (a) relationships between diabetes and pe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01442.x

    authors: Taylor GW,Borgnakke WS

    更新日期:2008-04-01 00:00:00