Abstract:
OBJECTIVES:To evaluate the expression of epidermal growth factor receptor (EGFR) and phosphorylated EGFR (pEGFR), in oral squamous cell carcinomas (OSCC). We examined their utility as prognostic markers by relating to clinicopathological characteristics and the clinical outcome. MATERIALS AND METHODS:We analysed 74 primary OSCC and examined immunohistochemical expression of EGFR and pEGFR (phosphorylated at tyrosine 1173) using tissue microarray technology. Their role in survival was assessed by Kaplan-Meier method and Cox regression models. RESULTS:Epidermal growth factor receptor expression was observed in all cases, and pEGFR expression was observed in 41.1% of the cases. We found a significant correlation between EGFR and pEGFR expression (P = 0.003). In the multivariable analysis for cause-specific survival, we found an independent prognostic value for pEGFR expression (HR 7.94, 95% CI 2.03-31.06, P = 0.003) and for clinical stage (HR 2.88, 95% CI 1.10-7.53, P = 0.031). For recurrence-free survival, clinical stage (HR 6.59, 95% CI 1.36-31.90, P = 0.019) and tumour grade (HR 3.35, 95% CI 1.07-10.44, P = 0.037) presented independent prognostic value. CONCLUSION:Epidermal growth factor receptor is highly expressed in OSCC and is phosphorylated in more than one-third of the cases. The independent value of pEGFR expression in cause-specific survival of OSCC suggests that this marker may serve as reliable biological marker to identify high-risk subgroups and to guide therapy.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Monteiro L,Ricardo S,Delgado M,Garcez F,do Amaral B,Lopes Cdoi
10.1111/odi.12087subject
Has Abstractpub_date
2014-03-01 00:00:00pages
178-85issue
2eissn
1354-523Xissn
1601-0825journal_volume
20pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract:OBJECTIVE:The present study summarizes the current knowledge on the role of bacterial extracellular signaling systems, known as quorum sensing (QS), in oral biofilm formation, and on the possibility of blocking these microbial communication systems as a potential approach to prevent and treat oral infectious diseases. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13689
更新日期:2020-10-20 00:00:00
abstract:UNLABELLED:Reluctance of dentists to treat human immunodeficiency virus (HIV) positive patients represents a major concern. Many efforts have been extended towards the documentation of the extent of this reluctance and speculation of factors that influence it. OBJECTIVES:Assess the willingness of dentists in Jordan to...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01126.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels o...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12829
更新日期:2018-07-01 00:00:00
abstract::Candidosis is by far the commonest oral fungal infection in man and could manifest as an adverse effect of drug therapy such as inhaled or topically applied corticosteroids. Due to the anti-inflammatory and immunosuppressive effect steroids are used in the management of bronchial asthma and oral mucosal diseases. In t...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Oral-facial-digital syndrome (OFDS) type 1 (OFD1) is an X-linked dominant condition associated with embryonic male lethality. It almost always affects the oral cavity, face, and digits. It is considered to be a ciliopathy caused by mutations in the OFD1 gene. A variety of mutations have been described, and a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2011.01823.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVES:Cyclosporine A (CsA) is used as an immunosuppressive agent and its prominent side effect is the induction of gingival overgrowth. Type I plasminogen activator inhibitor (PAI-1) has shown to play an important role in CsA-induced gingival overgrowth. However, little is known about whether factors can modulate ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01653.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances. MATERIALS AND METHODS: Genomic DNA from 75 Tha...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2010.01722.x
更新日期:2011-03-01 00:00:00
abstract::Hyaline ring granuloma (HRG) is a rare and atypical foreign-body granulomatous chronic inflammatory condition. Our aim was to make a critical review of the literature cases and also to illustrate histochemical and immunohistochemical findings of a new case. A modified PICO strategy was used. Inclusion criteria were me...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13287
更新日期:2020-01-24 00:00:00
abstract:OBJECTIVE:To undertake a detailed histological investigation of a large series of adenomatoid odontogenic tumours (AOT) to document the frequency and histomorphology of secretory cells which might indicate an inductive capacity. MATERIALS AND METHODS:Haematoxylin and eosin stained sections of 51 cases of AOT were revi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01399.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To determine expression and localization of membrane-associated mucins within human keratinized and non-keratinized oral epithelia, and to explore transcriptional changes associated with primary Sjögren's syndrome. SUBJECTS AND METHODS:Mucin transcripts and glycoproteins were determined by RT-PCR and immuno...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13098
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of EBV-DNA, CMV-DNA and HPV-DNA in oral healthy mucosa of HIV-infected and renal transplant patients. To associate the detection of viral genomes with laboratory parameters of immunodeficiency, gender, antiretroviral and immunosuppressive therapy. DESIGN:A cross-sectional analysi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To assess the health-related quality of life (HRQOL) of patients complaining of halitosis at their first visit and at a later time when their complaint had diminished following therapy, using a self-administered questionnaire, the Medical Outcome Study Short Form-36 (SF-36). The aim of this study was to exami...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01102.x
更新日期:2005-01-01 00:00:00
abstract::The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12763
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:The aim of the present study was to compare the proliferation index of the epithelial cells between odontogenic keratocysts (OKC), orthokeratinized odontogenic cysts (OOC), dentigerous cysts (DC), and ameloblastomas. MATERIALS AND METHODS:The proliferation index, employing a novel cell proliferation marker ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1046/j.1354-523x.2003.00974.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes. DESIGN:MEDLINE search of the English language literature identified primary research reports published on (a) relationships between diabetes and pe...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2008.01442.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13420
更新日期:2020-10-01 00:00:00
abstract:INTRODUCTION:Clastic cells, originating from the monocyte-macrophage lineage, resorb mineralized tissues. In periapical periodontitis, alveolar bone around the tooth apex becomes resorbed; however, the roots of the teeth are often left intact by yet unknown mechanisms. Here, we examined the status of clastic cells in a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12824
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI). METHODS:Mutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the prima...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13657
更新日期:2020-09-29 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. METHODS:A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12113
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVES:The aim was to investigate the attitudes of people with HIV infection towards their own dental care provision and the possible implications for future resource allocation. DESIGN:Sixty-nine HIV positive subjects attending support groups in London were interviewed. Past and current dental visiting behaviour,...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1998.tb00250.x
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:Bisphosphonates are widely used to treat bone diseases such as osteoporosis. However, they may cause osteonecrosis of the jaw. Here, we investigated whether in vivo exposure to bisphosphonates has a different effect on long bone and jaw osteoclasts, and on the turnover of these different bones. MATERIALS AN...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12587
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Stress and menstrual cycle have been described as factors influencing bad breath, as they can alter oral homeostasis and contribute to the production of volatile sulfur compounds (VSC). OBJECTIVE:Considering that the experimenter's and volunteer's gender may influence the volunteer's responses to stress, th...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12011
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVES:It was hypothesized that beta 2 defensin (BD-2) is increased in RAU lesions compared with healthy controls to promote anti-microbial host defence. METHODS:RAU and control mucosa samples were subjected to quantitative real-time PCR and immunostained for BD-2, CD68, mast cell tryptase and 4-hydroxynonenal (4H...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12262
更新日期:2015-04-01 00:00:00
abstract:AIM:To investigate the accuracy of histological diagnosis of oral hemangioma, oral vascular malformation and oral pyogenic granuloma according to immunohistochemical evaluation of the human erythrocyte-type glucose transporter protein (GLUT-1), and to observe the immunoexpression of this protein in oral varix. MATERIA...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01246.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro. MATERIALS AND METHODS:Ninety-six dentin samples were prepared from 24 freshl...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.01762.x
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12197
更新日期:2014-11-01 00:00:00
abstract::Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13704
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVES:The role of radiotherapy (RT) for oligometastases is currently established in different oncological settings but data on salivary gland cancer (SGC) are lacking. We evaluated the role of RT in oligometastatic SGC patients, focusing on stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS:We perf...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13755
更新日期:2020-12-15 00:00:00
abstract:OBJECTIVE:Odontogenic keratocyst (OKC) is a benign lesion that tends to recur after surgical treatment. In an attempt to clarify the molecular basis underlining the OKC pathobiology, we aimed to analyze its proteomic profile. MATERIALS AND METHODS:We compared the proteomic profiles of five OKC and matched normal oral ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13598
更新日期:2020-08-09 00:00:00
abstract:OBJECTIVE:To detail a scoping review on the global and regional relative frequencies of oral mucosal disorders in the children based on both clinical studies and those reported from biopsy records. MATERIALS AND METHODS:A literature search was completed from 1 January 1990 to 31 December 2018 using PubMed and EMBASE. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13112
更新日期:2019-06-01 00:00:00