Current ideas to reduce or salvage radiation damage to salivary glands.

Abstract:

:Radiation-induced hyposalivation is still a major problem after radiotherapy for head and neck cancer. Current and promising new thoughts to reduce or salvage radiation damage to salivary gland tissue are explored. The main cause underlying radiation-induced hyposalivation is a lack of functional saliva-producing acinar cells resulting from radiation-induced stem cell sterilization. Current methods to prevent that damage are radiation techniques to reduce radiation-injury to salivary gland tissue, surgical techniques to relocate salivary glands to a region receiving a lower cumulative radiation dose, and techniques to make salivary gland cells more resistant to radiation injury. These preventive techniques cannot be applied in all cases, also reduce tumor sensitivity, or do not result in a sufficient amelioration of the dryness-related complaints. Therefore, alternative methods on techniques to salvage salivary glands that are damaged by radiation are explored with promising results, such as stem cell therapies and gene transfer techniques to allow the radiation-injured salivary gland tissue to secrete water.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Vissink A,van Luijk P,Langendijk JA,Coppes RP

doi

10.1111/odi.12222

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

e1-10

issue

1

eissn

1354-523X

issn

1601-0825

journal_volume

21

pub_type

杂志文章,评审
  • Palatal zygomycosis: experience of 21 cases.

    abstract:OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a bi...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01433.x

    authors: Bonifaz A,Macias B,Paredes-Farrera F,Arias P,Ponce RM,Araiza J

    更新日期:2008-09-01 00:00:00

  • ELISA test for p63 antibodies in chronic ulcerative stomatitis.

    abstract:OBJECTIVE:To develop a novel test for chronic ulcerative stomatitis (CUS), a chronic immunologically mediated condition that produces oral ulcerations. Current diagnostic methods require expensive and technically demanding in situ immunofluorescence (IF) studies. DESIGN:An Enzyme-Linked ImmunoSorbent Assay (ELISA) was...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01606.x

    authors: Solomon LW,Stark PC,Winter L,Kumar V,Sinha S

    更新日期:2010-03-01 00:00:00

  • Stimulatory response of neutrophils from periodontitis patients with periodontal pathogens.

    abstract:OBJECTIVE:Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in healthy controls towards stimulation to Porphyromonas gingivalis (Pg) and Actinobacillus actinomyce...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01323.x

    authors: Restaíno CG,Chaparro A,Valenzuela MA,Kettlun AM,Vernal R,Silva A,Puente J,Jaque MP,León R,Gamonal J

    更新日期:2007-09-01 00:00:00

  • Intra-oral carcinomas in Maiduguri, north-eastern Nigeria.

    abstract:OBJECTIVE:To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria. DESIGN AND SETTING:A retrospective clinical and histopathological review seen in a tertiary care hospital (January 1987-December 2002). MATERIALS AND METHODS:Information on socio-demographic characteristics of patients and ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2005.01134.x

    authors: Otoh EC,Johnson NW,Olasoji HO,Danfillo IS,Adeleke OA

    更新日期:2005-11-01 00:00:00

  • Pigmented lesions of the oral mucosa: A cross-sectional study of 458 histopathological specimens.

    abstract:OBJECTIVES:To evaluate clinical, demographic, and histopathological characteristics of pigmented lesions of the oral mucosa. MATERIALS AND METHODS:A cross-sectional study was conducted over a 64-year period. Information was collected from medical charts, and all archived histopathological specimens with diagnoses of a...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12924

    authors: Tavares TS,Meirelles DP,de Aguiar MCF,Caldeira PC

    更新日期:2018-11-01 00:00:00

  • The dynamics of the oral microbiome and oral health among patients receiving clear aligner orthodontic treatment.

    abstract:OBJECTIVES:This 6-month prospective clinical study assessed the impacts of Invisalign appliances on the oral bacterial community and oral health of patients. METHODS:Salivary samples were obtained from twenty-five adult patients receiving Invisalign aligner treatment before the treatment (Group B) and at a 6-month fol...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13175

    authors: Zhao R,Huang R,Long H,Li Y,Gao M,Lai W

    更新日期:2020-03-01 00:00:00

  • Global oral inequalities in HIV infection.

    abstract::Analysis of the prevalence and incidence of HIV infection globally reveal striking variances with regard to continent, country, region and gender. Of the global total of 33 million people infected with HIV, approximately 65% are in sub-Saharan African countries and 15% in South and South-East Asia with the remaining 2...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12408

    authors: Challacombe SJ

    更新日期:2016-04-01 00:00:00

  • Cytokeratins in epithelia of odontogenic neoplasms.

    abstract::Neoplasms and tumours related to the odontogenic apparatus may be composed only of epithelial tissue or epithelial tissue associated with odontogenic ectomesenchyme. The immunohistochemical detection of different cytokeratins (CKs) polypeptides and vimentin has made it easier to explain the histogenesis of many epithe...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.00861.x

    authors: Crivelini MM,de Araújo VC,de Sousa SO,de Araújo NS

    更新日期:2003-01-01 00:00:00

  • New thoughts on the initiation of mucositis.

    abstract::It has been slightly more than a decade since the classic mechanistic paradigm that defined the pathogenesis of mucositis was revised. A five-stage sequence of linked biological events forms the basis for our current understanding of how regimen-related mucosal injury occurs. The first stage is the initiation phase, a...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01681.x

    authors: Sonis ST

    更新日期:2010-10-01 00:00:00

  • Sex hormone replacement therapy in periodontology-A systematic review.

    abstract:OBJECTIVE:To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. MATERIALS AND METHODS:Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/MEDLINE. Human observational and intervent...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13059

    authors: Chaves JDP,Figueredo TFM,Warnavin SVSC,Pannuti CM,Steffens JP

    更新日期:2020-03-01 00:00:00

  • The heme oxygenase system and oral diseases.

    abstract::Oral Diseases (2011) 17, 252-257 Heme oxygenase (HO) system catabolizes heme into three products: carbon monoxide (CO), biliverdin/bilirubin and free iron, which consists of three forms identified to date: the oxidative stress-inducible protein HO-1 and the constitutive isozymes HO-2 and HO-3. HO has been involved in ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01732.x

    authors: Fan W,Huang F,Zhu X,Li D,Fu S,He H

    更新日期:2011-04-01 00:00:00

  • Secretory leukocyte protease inhibitor (SLPI) in mucosal fluids inhibits HIV-I.

    abstract::Despite the presence of HIV-1 in the oral cavity, transmission of the virus through saliva has not been proven. Consistent with these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro. Whereas other salivary ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00377.x

    authors: Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

    更新日期:1997-05-01 00:00:00

  • Is erythematous candidiasis associated with advanced HIV disease?

    abstract:OBJECTIVES:A multicentre collaborative study by the London HIV and Dentistry Group failed to associate the presence of erythematous candidiasis (EC) with advanced HIV disease. Data from a study of the periodontal health of homosexual men attending a genito-urinary medicine clinic presented an opportunity to investigate...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00339.x

    authors: Robinson PG,Challacombe SJ,Sheiham A,Zakrzewska JM

    更新日期:1997-05-01 00:00:00

  • Evaluation of a rapamycin-regulated serotype 2 adeno-associated viral vector in macaque parotid glands.

    abstract:OBJECTIVES:Salivary glands are useful target organs for local and systemic gene therapeutics. For such applications, the regulation of transgene expression is important. Previous studies by us in murine submandibular glands showed that a rapamycin transcriptional regulation system in a single serotype 2, adeno-associat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01631.x

    authors: Zheng C,Voutetakis A,Metzger M,Afione S,Cotrim AP,Eckhaus MA,Rivera VM,Clackson T,Chiorini JA,Donahue RE,Dunbar CE,Baum BJ

    更新日期:2010-04-01 00:00:00

  • Sentinels and signposts: the epidemiology and significance of the oral manifestations of HIV disease.

    abstract::A large number of studies attest to the frequency of oral disease in those with HIV infection. Most show that hairy leukoplakia and pseudomembranous candidiasis are the commonest lesions in those with HIV infection and AIDS, with higher prevalence and incidence rates correlating with falling CD4 counts and disease pro...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00344.x

    authors: Greenspan JS

    更新日期:1997-05-01 00:00:00

  • Effect of aluminum concentration on dental caries formation in the rat.

    abstract:OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on fo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1995.tb00164.x

    authors: Putt MS,Kleber CJ

    更新日期:1995-06-01 00:00:00

  • Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study.

    abstract:AIM:To investigate prospectively the qualitative and quantitative changes in oral carriage of yeasts and coliforms in southern Chinese people suffering from stroke. MATERIALS AND METHODS:In 56 elderly people suffering from stroke in a rehabilitation unit of a general medical hospital in Hong Kong, oral microbiological...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01347.x

    authors: Zhu HW,McMillan AS,McGrath C,Li LS,Samaranayake LP

    更新日期:2008-01-01 00:00:00

  • Individual and contextual determinants of dental pain in adolescents: Evidence from a national survey.

    abstract:OBJECTIVE:To investigate the prevalence of dental pain among adolescent students and its association with individual, school and city variables, using a multilevel approach. SUBJECTS AND METHODS:Individual and school data were obtained from the National Adolescent School-Based Health Survey (PeNSE) conducted in Brazil...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13100

    authors: Freire MCM,Nery NG,Jordão LMR,Abreu MHNG

    更新日期:2019-07-01 00:00:00

  • Orofacial granulomatosis--a 20-year review.

    abstract::Orofacial granulomatosis (OFG) is the presence of persistent enlargement of the soft tissues of the oral and maxillofacial region, characterized by non-caseating granulomatous inflammation in the absence of diagnosable systemic Crohn's disease (CD) or sarcoidosis. Over 20 years have passed since OFG was first describe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01500.x

    authors: Grave B,McCullough M,Wiesenfeld D

    更新日期:2009-01-01 00:00:00

  • Defensin-1, an antimicrobial peptide present in the saliva of patients with oral diseases.

    abstract:OBJECTIVES AND DESIGN:A preceding paper has noted a detection of defensin-1 (HNP-1), a peptide with antimicrobial and cytotoxic properties, in the saliva of patients with oral squamous cell carcinoma. The present study deals with the presence of HNP-1 in the saliva of patients with various oral diseases. METHODS:Whole...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1999.tb00078.x

    authors: Mizukawa N,Sugiyama K,Ueno T,Mishima K,Takagi S,Sugahara T

    更新日期:1999-04-01 00:00:00

  • Rechargeable anticandidal denture material with sustained release in saliva.

    abstract:OBJECTIVE:Candida-induced denture stomatitis is a common debilitating problem among denture wearers. Previously, we described the fabrication of a new denture material that released antifungal drugs when immersed in phosphate buffered saline. Here, we use more clinically relevant immersion conditions (human saliva; 37°...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12456

    authors: Malakhov A,Wen J,Zhang BX,Wang H,Geng H,Chen XD,Sun Y,Yeh CK

    更新日期:2016-07-01 00:00:00

  • Oral adverse effects of drugs: Taste disorders.

    abstract:OBJECTIVE:Oral healthcare professionals are frequently confronted with patients using drugs on a daily basis. These drugs can cause taste disorders as adverse effect. The literature that discusses drug-induced taste disorders is fragmented. This article aims to support oral healthcare professionals in their decision ma...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13199

    authors: Rademacher WMH,Aziz Y,Hielema A,Cheung KC,de Lange J,Vissink A,Rozema FR

    更新日期:2020-01-01 00:00:00

  • Gingival crevicular fluid matrix metalloproteinase-13 levels and molecular forms in various types of periodontal diseases.

    abstract:BACKGROUND:The purpose of this study was to evaluate the levels, molecular forms and activation degree of matrix metalloproteinase-13 (MMP-13) in the gingival crevicular fluid (GCF) of patients with periodontal diseases and to correlate these findings with periodontal clinical parameters. METHODS:Sixty one subjects pa...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01244.x

    authors: Ilgenli T,Vardar-Sengul S,Gürkan A,Sorsa T,Stackelberg S,Köse T,Atilla G

    更新日期:2006-11-01 00:00:00

  • Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours.

    abstract:OBJECTIVES:We determined the correlation between saliva and serum for CA125 and leptin, and evaluated their clinical screening potential for parotid tumours. SUBJECTS AND METHODS:Serum, acid-stimulated bilateral parotid saliva and chewing-stimulated whole saliva were collected and measured the levels of CA125 and lept...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12505

    authors: Zhang KY,Liu CY,Hua L,Wang SL,Li J

    更新日期:2016-10-01 00:00:00

  • HIV infection and periodontal diseases: an overview of the post-HAART era.

    abstract::HIV infection remains a global health problem of unprecedented dimensions, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable chronic disease with longer survival and improved quality of life in HIV-infected subjects. Among th...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01727.x

    authors: Mataftsi M,Skoura L,Sakellari D

    更新日期:2011-01-01 00:00:00

  • Prevalence of six periodontal pathogens detected by DNA probe method in HIV vs non-HIV periodontitis.

    abstract:OBJECTIVE:The aim of the study was to examine the prevalence of selected periodontal pathogens associated with HIV and non-HIV related periodontal lesions. METHODS:Subgingival plaque samples were obtained from both HIV-seropositive and HIV-seronegative patients affected with periodontal disease. DNA probes were used t...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1997.tb00350.x

    authors: Tenenbaum H,Elkaim R,Cuisinier F,Dahan M,Zamanian P,Lang JM

    更新日期:1997-05-01 00:00:00

  • Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients--randomized study.

    abstract:OBJECTIVE:To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP). METHODS:Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2012.01943.x

    authors: Gilowski L,Kondzielnik P,Wiench R,Płocica I,Strojek K,Krzemiński TF

    更新日期:2012-11-01 00:00:00

  • Neuralgia-inducing cavitational osteonecrosis: a status report.

    abstract::Neuralgia-inducing cavitational osteonecrosis remains controversial several years following the initial description. Changing etiologic concepts have led to confusion as well as the significant departures from the concept first defined by Ratner which served as the basis for the explaining the pain syndrome with featu...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2009.01532.x

    authors: Sciubba JJ

    更新日期:2009-07-01 00:00:00

  • Periodontitis in tonsil cancer patients-A comparative study in accordance with tumour p16 status.

    abstract:OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were per...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13437

    authors: Keinänen A,Marinescu-Gava M,Uittamo J,Hagström J,Marttila E,Snäll J

    更新日期:2020-11-01 00:00:00

  • Traditional Chinese medicine and oral diseases: today and tomorrow.

    abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01706.x

    authors: Zheng LW,Hua H,Cheung LK

    更新日期:2011-01-01 00:00:00