Current ideas to reduce or salvage radiation damage to salivary glands.


:Radiation-induced hyposalivation is still a major problem after radiotherapy for head and neck cancer. Current and promising new thoughts to reduce or salvage radiation damage to salivary gland tissue are explored. The main cause underlying radiation-induced hyposalivation is a lack of functional saliva-producing acinar cells resulting from radiation-induced stem cell sterilization. Current methods to prevent that damage are radiation techniques to reduce radiation-injury to salivary gland tissue, surgical techniques to relocate salivary glands to a region receiving a lower cumulative radiation dose, and techniques to make salivary gland cells more resistant to radiation injury. These preventive techniques cannot be applied in all cases, also reduce tumor sensitivity, or do not result in a sufficient amelioration of the dryness-related complaints. Therefore, alternative methods on techniques to salvage salivary glands that are damaged by radiation are explored with promising results, such as stem cell therapies and gene transfer techniques to allow the radiation-injured salivary gland tissue to secrete water.


Oral Dis


Oral diseases


Vissink A,van Luijk P,Langendijk JA,Coppes RP




Has Abstract


2015-01-01 00:00:00












  • An immunohistochemical study of p53 and PCNA in inflammatory papillary hyperplasia of the palate: a dilemma of interpretation.

    abstract:OBJECTIVE:Inflammatory papillary hyperplasia of the palate (IPHP) or the granular type of denture stomatitis, is a non-neoplastic lesion characterized histologically by a significant epithelial hyperplasia and inflammatory infiltrate usually caused by trauma and Candida infection. p53 and proliferative cell nuclear ant...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Kaplan I,Vered M,Moskona D,Buchner A,Dayan D

    更新日期:1998-09-01 00:00:00

  • Locally delivered antimicrobials for the treatment of chronic periodontitis.

    abstract::The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Etienne D

    更新日期:2003-01-01 00:00:00

  • Rehabilitation of lost teeth related to maintenance of cognitive function.

    abstract:OBJECTIVE:As the era of aging comes, cognitive impairment (CI) is increasing. The impact of rehabilitation of lost tooth on CI remains unclear. This study aimed to investigate whether non-rehabilitated lost teeth (NRLT) is associated with CI among Korean elders. METHODS:A total of 280 elders comprising of 140 cases an...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Shin MS,Shin YJ,Karna S,Kim HD

    更新日期:2019-01-01 00:00:00

  • Clinical, microbiological and ultrastructural features of angular cheilitis lesions in Southern Chinese.

    abstract:OBJECTIVE:To obtain baseline data on angular cheilitis in Southern Chinese. DESIGN:A cross-sectional investigation of the clinical, microbiological and ultrastructural features of the condition. SUBJECTS AND METHOD:Thirty six Chinese adults with angular cheilitis; 28 controls matched for age and sex, with no inflamma...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Dias AP,Samaranayake LP

    更新日期:1995-03-01 00:00:00

  • Cigarette smoking, alcohol drinking, and oral and pharyngeal cancer mortality in Japan.

    abstract:OBJECTIVES:To prospectively examine the association of cigarette smoking and alcohol drinking with oral and pharyngeal carcinogenesis, we analyzed data from a nation-wide large-scale cohort study in Japan. METHODS:A total of 34 136 men and 43 711 women aged 40-79 years were included in the study. The Cox proportional ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Ide R,Mizoue T,Fujino Y,Hoshiyama Y,Sakata K,Tamakoshi A,Yoshimura T,JACC Study Group.

    更新日期:2008-05-01 00:00:00

  • Quorum sensing systems as a new target to prevent biofilm-related oral diseases.

    abstract:OBJECTIVE:The present study summarizes the current knowledge on the role of bacterial extracellular signaling systems, known as quorum sensing (QS), in oral biofilm formation, and on the possibility of blocking these microbial communication systems as a potential approach to prevent and treat oral infectious diseases. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Muras A,Mallo N,Otero-Casal P,Pose-Rodríguez JM,Otero A

    更新日期:2020-10-20 00:00:00

  • Effects of neratinib and combination with irradiation and chemotherapy in head and neck cancer cells.

    abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Schneider S,Thurnher D,Kadletz L,Seemann R,Brunner M,Kotowski U,Schmid R,Lill C,Heiduschka G

    更新日期:2016-11-01 00:00:00

  • MicroRNA-21 promotes orthodontic tooth movement by modulating the RANKL/OPG balance in T cells.

    abstract:OBJECTIVES:The present study was designed to investigate the effects of microRNA-21 (miR-21) on orthodontic tooth movement. METHODS:The orthodontic tooth movement model was established in C57BL/6 and miR-21-/- mice with or without implantation of activated T cells. Histological and histomorphometrical analyses were pe...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Wu L,Su Y,Lin F,Zhu S,Wang J,Hou Y,Du J,Liu Y,Guo L

    更新日期:2020-03-01 00:00:00

  • The use of tretinoin as oral mucositis prophylaxis in bone marrow transplantation patients: a preliminary study.

    abstract:OBJECTIVE:The examination of prophylactic efficacy of tretinoin on oral mucositis, post bone marrow transplantation (BMT). PATIENTS AND METHODS:The study population consisted of 11 patients undergoing BMT. Six tretinoin topically-treated patients (0.25 mg daily of 0.1% tretinoin cream) were matched with five non-treat...

    journal_title:Oral diseases

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cohen G,Elad S,Or R,Galili D,Garfunkel AA

    更新日期:1997-12-01 00:00:00

  • An update of knowledge on the regulatory role of Treg cells in apical periodontitis.

    abstract::Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals, thereb...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Wei L,Xu M,Xiong H

    更新日期:2020-06-02 00:00:00

  • Salivary protein candidates for biomarkers of oral disorders in alcohol and tobacco dependents.

    abstract:OBJECTIVES:To evaluate the oral condition of alcohol and tobacco dependents and identify salivary protein candidates for biomarkers of oral disorders. SUBJECTS AND METHODS:Thirty-three male volunteers were evaluated for alcohol abuse rehabilitation; nine were selected for proteomic analysis. Intraoral examination was ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Penteado CAS,Batista TBD,Chaiben CL,Bonacin BG,Ventura TMO,Dionizio A,Couto Souza PH,Buzalaf MAR,Azevedo-Alanis LR

    更新日期:2020-04-01 00:00:00

  • Efficacy of hypermethylated DNA biomarkers in saliva and oral swabs for oral cancer diagnosis: Systematic review and meta-analysis.

    abstract:OBJECTIVES:This study aims to determine the diagnostic test accuracy (DTA) of hypermethylated DNA biomarkers in saliva and oral swabs for oral squamous cell carcinoma (OSCC) detection from the prevalidation studies available. MATERIALS AND METHODS:Electronic database searching of PubMed, EMBASE, Cochrane Library, Scop...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Adeoye J,Alade AA,Zhu WY,Wang W,Choi SW,Thomson P

    更新日期:2021-01-10 00:00:00

  • Bifunctional anticaries peptides with antibacterial and remineralizing effects.

    abstract:OBJECTIVES:Initial dental caries often occurs in clinic. Reduction of cariogenic bacteria and promotion of remineralization are effective ways to control them. This study was to develop bifunctional anticaries peptides with antibacterial and remineralizing properties. METHODS:We designed peptides TDH19, TNH19, and TVH...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Wang X,Wang Y,Wang K,Ren Q,Li H,Zheng S,Niu Y,Zhou X,Li W,Zhang L

    更新日期:2019-03-01 00:00:00

  • Periodontitis in patients with psoriasis: A systematic review and meta-analysis.

    abstract:OBJECTIVE:The present study aimed to summarize and update the evidence regarding the association between periodontitis and psoriasis. METHODS:The present systematic review was conducted under the guidelines of Transparent Reporting of Systematic Reviews and Meta-Analyses (PRISMA) and was recorded in the PROSPERO datab...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Zhang X,Gu H,Xie S,Su Y

    更新日期:2020-08-27 00:00:00

  • Immunohistochemical evaluation of TGF-beta and extracellular matrix proteins expression in rat squamous cell carcinomas.

    abstract:OBJECTIVE:The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (la...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Poulopoulos AK,Kayavis IG,Papanayotou P

    更新日期:1996-03-01 00:00:00

  • YouTube as a source of information on mouth (oral) cancer.

    abstract:OBJECTIVES:We examined the content of YouTube(™) videos on mouth (oral) cancer and evaluated their usefulness in promoting early detection of oral cancer. MATERIALS AND METHODS:A systematic search of YouTube(™) for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Hassona Y,Taimeh D,Marahleh A,Scully C

    更新日期:2016-04-01 00:00:00

  • Marathon of eponyms: 25 Yersiniosis.

    abstract::The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry,...

    journal_title:Oral diseases

    pub_type: 传,历史文章,杂志文章


    authors: Scully C,Langdon J,Evans J

    更新日期:2012-05-01 00:00:00

  • Hyaline ring granuloma of the mouth-A foreign-body reaction that dentists should be aware of: Critical review of literature and histochemical/immunohistochemical study of a new case.

    abstract::Hyaline ring granuloma (HRG) is a rare and atypical foreign-body granulomatous chronic inflammatory condition. Our aim was to make a critical review of the literature cases and also to illustrate histochemical and immunohistochemical findings of a new case. A modified PICO strategy was used. Inclusion criteria were me...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Kimura TC,Carneiro MC,Coelho YFS,de Sousa SCOM,Veltrini VC

    更新日期:2020-01-24 00:00:00

  • Osteoclast activation in inflammatory periodontal diseases.

    abstract:OBJECTIVE:In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis. SUMMARY:Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the b...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Wiebe SH,Hafezi M,Sandhu HS,Sims SM,Dixon SJ

    更新日期:1996-06-01 00:00:00

  • Salivary gland malignancies - an update on current management for oral healthcare practitioners.

    abstract::Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Green B,Rahimi S,Brennan PA

    更新日期:2016-11-01 00:00:00

  • Prevalence and distribution of oral lesions: a cross-sectional study in Turkey.

    abstract:OBJECTIVES:The purpose of this study was to evaluate the prevalence and distribution of oral lesions (OLs) in Turkish population. SUBJECTS AND METHODS:In this cross-sectional study, 765 residents (F/M: 375/390) were selected by the cluster sampling method and examined according to WHO criteria. RESULTS:Excessive mela...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Mumcu G,Cimilli H,Sur H,Hayran O,Atalay T

    更新日期:2005-03-01 00:00:00

  • Betel and tobacco chewing habit and its relation to risk factors for periodontal disease.

    abstract:OBJECTIVES:To comparatively assess periodontal status in patients who chew different products and patients who do not have this habit and to assess how this practice interacts with predisposing factors and risk indicators of disease. METHODS:Patients included in the dental care carried out in a rural community in Indi...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Giovannoni ML,Valdivia-Gandur I,Lozano de Luaces V,Varela Véliz H,Balasubbaiah Y,Chimenos-Küstner E

    更新日期:2018-07-01 00:00:00

  • Chemokines and chemokine receptors: the key to understanding AIDS.

    abstract::This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...

    journal_title:Oral diseases

    pub_type: 社论,评审


    authors: Thornhill MH,Li J

    更新日期:1997-03-01 00:00:00

  • MSX1 gene polymorphisms and non-syndromic cleft lip with or without palate (NSCL/P): A meta-analysis.

    abstract:OBJECTIVE:Non-syndromic cleft lip, with or without cleft palate (NSCL/P), is a common craniofacial birth defect, the risk of which is influenced from multiple genetic loci. Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P have been incon...

    journal_title:Oral diseases

    pub_type: 杂志文章,meta分析,评审


    authors: Tasanarong P,Pabalan N,Tharabenjasin P,Jarjanazi H

    更新日期:2019-09-01 00:00:00

  • Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.

    abstract:OBJECTIVE:To investigate the therapeutic effect of oral glucosamine (GS) as an adjunct to hyaluronic acid (HA) injection on patients with temporomandibular joint osteoarthritis (TMJ OA). METHODS:In this clinical trial, 136 participants, diagnosed as TMJ OA clinically and radiographically, were enrolled and randomized ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验


    authors: Cen X,Liu Y,Wang S,Yang X,Shi Z,Liang X

    更新日期:2018-04-01 00:00:00

  • A comparative study of epithelial cell proliferation between the odontogenic keratocyst, orthokeratinized odontogenic cyst, dentigerous cyst, and ameloblastoma.

    abstract:OBJECTIVES:The aim of the present study was to compare the proliferation index of the epithelial cells between odontogenic keratocysts (OKC), orthokeratinized odontogenic cysts (OOC), dentigerous cysts (DC), and ameloblastomas. MATERIALS AND METHODS:The proliferation index, employing a novel cell proliferation marker ...

    journal_title:Oral diseases

    pub_type: 杂志文章


    authors: Thosaporn W,Iamaroon A,Pongsiriwet S,Ng KH

    更新日期:2004-01-01 00:00:00

  • Mucoepidermoid carcinoma of minor salivary glands: a clinical study of 16 cases and review of the literature.

    abstract:OBJECTIVE:Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of salivary glands with a widely diverse biologic behavior that is correlated with the histological grade of the tumor. The purpose of this study was to evaluate the clinical outcomes of MEC of minor salivary glands in a group of 16 patients, w...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Triantafillidou K,Dimitrakopoulos J,Iordanidis F,Koufogiannis D

    更新日期:2006-07-01 00:00:00

  • Periodontal disease: associations with diabetes, glycemic control and complications.

    abstract:OBJECTIVE:This report reviews the evidence for adverse effects of diabetes on periodontal health and periodontal disease on glycemic control and complications of diabetes. DESIGN:MEDLINE search of the English language literature identified primary research reports published on (a) relationships between diabetes and pe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Taylor GW,Borgnakke WS

    更新日期:2008-04-01 00:00:00

  • Traditional Chinese medicine and oral diseases: today and tomorrow.

    abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Zheng LW,Hua H,Cheung LK

    更新日期:2011-01-01 00:00:00

  • Metabolic hormones in saliva: origins and functions.

    abstract::The salivary proteome consists of thousands of proteins, which include, among others, hormonal modulators of energy intake and output. Although the functions of this prominent category of hormones in whole body energy metabolism are well characterized, their functions in the oral cavity, whether as a salivary componen...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审


    authors: Zolotukhin S

    更新日期:2013-04-01 00:00:00