Abstract:
OBJECTIVE:The Family with sequence similarity 5 member C (FAM5C) has been suggested to contribute in aggressive periodontitis. However, there is no data regarding its role in chronic periodontitis. The aim of this study was to evaluate the FAM5C expression in chronic periodontitis and to study association of FAM5C with key immunoinflammatory markers. MATERIAL AND METHODS:Gingival biopsies were harvested from periodontally healthy subjects (n = 10) and chronic periodontitis subjects (n = 15). The levels of mRNA of FAM5C, interleukin (IL)-17, IL-6, IL-23, IL-10, IL-4, interferon-c, toll-like receptor (TLR)-2, TLR-4, osteoprotegerin (OPG), receptor activator of NF-κB ligand (RANKL), tumor necrosis factor (TNF)-a, transforming growth factor-b, transcription factor forkhead box p3, and transcription factor orphan nuclear receptor C2 were evaluated by real-time polymerase chain reaction. RESULTS:FAM5C mRNA levels were not different between periodontally healthy and diseased tissues (P > 0.05). Gene expressions of IL-17, TNF-a, OPG, RANKL, TLR-2, and TLR-4 were higher in periodontitis, when compared to periodontally healthy sites (P < 0.05), while no differences between groups were observed for the other genes evaluated (P > 0.05). There were no correlations between the gene expression of FAM5C and the other immunoinflammatory markers (P > 0.05). CONCLUSION:Within the limits of this study, it seems that FAM5C expression does not contribute to chronic periodontitis.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Ribeiro FV,Santos VR,Bastos MF,De Miranda TS,Vieira AR,De Figueiredo LC,Duarte PMdoi
10.1111/j.1601-0825.2011.01855.xsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
147-52issue
2eissn
1354-523Xissn
1601-0825journal_volume
18pub_type
杂志文章相关文献
ORAL DISEASES文献大全abstract:OBJECTIVE:Radicular cysts occur as a result of the immunological response to continuous antigenic stimulation from root canals. We correlated the immunophenotypical composition of the lymphoid infiltrate to the microvessel density expressed by the count of CD34 reactive endothelial cells in radicular cysts. SUBJECTS A...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2012.01961.x
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:To propose the application of the concept of geriatric syndrome for common geriatric oral and maxillofacial dysfunctions and to suggest the necessity of developing effective evaluation methods for oral and maxillofacial frailty. DESIGN:The concepts of frailty and geriatric syndrome based on multi-morbidity ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12647
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To test whether the submandibular/sublingual (SMSL) salivary secretion, mucin concentration and candida carriage status were altered in human immunodeficiency virus-positive (HIV+) patients. SUBJECTS AND METHODS:SMSL saliva collected from 48 HIV-infected and 31 HIV-negative men were analyzed for flow rates,...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01514.x
更新日期:2009-04-01 00:00:00
abstract::Well into the fourth decade of the HIV/AIDS pandemic, we can look back on the early years, the initial discoveries, and the broad sweep of the progress of our understanding of the nature, causes, and significance of the oral lesions seen in those infected with the virus. Prominent among these is oral hairy leukoplakia...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12393
更新日期:2016-04-01 00:00:00
abstract::The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1034/j.1601-0825.9.s1.8.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria. DESIGN AND SETTING:A retrospective clinical and histopathological review seen in a tertiary care hospital (January 1987-December 2002). MATERIALS AND METHODS:Information on socio-demographic characteristics of patients and ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2005.01134.x
更新日期:2005-11-01 00:00:00
abstract::The salivary proteome consists of thousands of proteins, which include, among others, hormonal modulators of energy intake and output. Although the functions of this prominent category of hormones in whole body energy metabolism are well characterized, their functions in the oral cavity, whether as a salivary componen...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12015
更新日期:2013-04-01 00:00:00
abstract::Oral candidiasis is perhaps the commonest infection seen in HIV disease. The aim of this workshop was to provide a sketch of the multifarious aspects of the disease from a global perspective. To this end the panellists addressed issues such as the virulence of Candida, emergence of antifungal resistance, management of...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1034/j.1601-0825.8.s2.6.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in healthy controls towards stimulation to Porphyromonas gingivalis (Pg) and Actinobacillus actinomyce...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01323.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Orofacial clefts (OFCs) are common and etiologically complex birth defects. This study explored potential genetic differences in a pair of Japanese monozygotic (MZ) twins with different forms of OFC using whole-genome sequencing. SUBJECTS AND METHODS:One co-twin (MZ-1) presented with nonsyndromic bilateral c...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12910
更新日期:2018-10-01 00:00:00
abstract::Proliferative verrucous leukoplakia (PVL) is of uncertain etiology but may be associated with human papillomavirus (HPV) infection. Proliferative verrucous leukoplakia is seen mainly in older women, beginning as a simple slow-growing, persistent leukoplakia that tends to spread and become multifocal and affect the gin...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2009.01632.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVES:This review aims to evaluate the efficacy of xenogeneic collagen matrix (XCM) for the treatment of single or multiple gingival recessions in terms of clinical parameters and patient-related outcomes. MATERIALS AND METHODS:Various electronic databases (The Cochrane Central Register of Controlled Trials, MEDL...
journal_title:Oral diseases
pub_type: 杂志文章,meta分析
doi:10.1111/odi.12949
更新日期:2019-05-01 00:00:00
abstract::This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...
journal_title:Oral diseases
pub_type: 社论,评审
doi:10.1111/j.1601-0825.1997.tb00002.x
更新日期:1997-03-01 00:00:00
abstract:OBJECTIVES:X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED and NSH. This study investigated the genetic causes of six hypohidrotic ectode...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12376
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:In this paper, we review the mechanisms thought to be involved in the activation of osteoclasts in periodontitis. SUMMARY:Osteoclasts are regulated by both microbial and host factors. Some factors act directly on cells of the osteoclast lineage, whereas others act indirectly through other cell types in the b...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1996.tb00218.x
更新日期:1996-06-01 00:00:00
abstract::The use of eponyms has long been contentious, but many remain in common use, as discussed elsewhere (Editorial: Oral Diseases. 2009: 15; 185). The use of eponyms in diseases of the head and neck is found mainly in specialties dealing with medically compromised individuals (paediatric dentistry, special care dentistry,...
journal_title:Oral diseases
pub_type: 传,历史文章,杂志文章
doi:10.1111/j.1601-0825.2009.01557.x
更新日期:2012-05-01 00:00:00
abstract:UNLABELLED:Abnormalities in the p53 gene are regarded as the most consistent genetic abnormalities detected in head and neck squamous cell carcinogenesis. Two new members of the p53 gene family, p73 at the 1p36 region and p63 at the 3q27-29 region, have recently been identified. They share considerable sequence homolog...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2003.02920.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:Inflammatory papillary hyperplasia of the palate (IPHP) or the granular type of denture stomatitis, is a non-neoplastic lesion characterized histologically by a significant epithelial hyperplasia and inflammatory infiltrate usually caused by trauma and Candida infection. p53 and proliferative cell nuclear ant...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1998.tb00278.x
更新日期:1998-09-01 00:00:00
abstract::The first World Workshop on Oral AIDS was held in San Diego in 1988, organized by John and Deborah Greenspan who saw the need and advantages of getting together all those health workers globally who were interested in oral aspects of HIV with a common purpose of advancing the field collectively and collaboratively. Si...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13385
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Oral-facial-digital syndrome (OFDS) type 1 (OFD1) is an X-linked dominant condition associated with embryonic male lethality. It almost always affects the oral cavity, face, and digits. It is considered to be a ciliopathy caused by mutations in the OFD1 gene. A variety of mutations have been described, and a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2011.01823.x
更新日期:2011-09-01 00:00:00
abstract:OBJECTIVE:Cathepsin K was initially discovered as an osteoclast-specific cysteine proteinase, but the enzyme is also expressed in various cancers including oral squamous cell carcinomas. This study aimed to clarify the function of cathepsin K in oral squamous cell carcinomas. MATERIALS AND METHODS:Expression levels of...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12643
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVES:To assess the effects of periodontitis on renal interstitial fibrosis in a mouse model. MATERIALS AND METHODS:Thirty C57BL/6 male mice were divided into control, periodontitis (PD), unilateral ureteral ligation (UUO) and PD+UUO groups. Unilateral ureteral ligation was performed 6 days after periodontitis. A...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13764
更新日期:2020-12-31 00:00:00
abstract:OBJECTIVE:To explore the role of CD10 in cisplatin resistance of oral squamous cell carcinoma (OSCC) and its association with the Hedgehog (Hh) signaling pathway and cancer stem cells (CSCs). METHODS:The correlation between cell viability and CD10 expression was analyzed in different OSCC cell lines after the cisplati...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13673
更新日期:2020-10-09 00:00:00
abstract::Oral Diseases (2011) 17, 252-257 Heme oxygenase (HO) system catabolizes heme into three products: carbon monoxide (CO), biliverdin/bilirubin and free iron, which consists of three forms identified to date: the oxidative stress-inducible protein HO-1 and the constitutive isozymes HO-2 and HO-3. HO has been involved in ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2010.01732.x
更新日期:2011-04-01 00:00:00
abstract::Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12498
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:Subjects with cleft lip and palate (CLP) present high prevalence of dental agenesis. Among candidate genes for these phenotypes is IRF6. However, genetic studies do not analyze dental agenesis as a phenotype associated with cleft. Therefore, we investigated the frequency of rare and novel variations in IRF6 i...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12975
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVES:Fibrosis diseases are one of the leading causes of suffering and death. However, no systematic investigation has been carried out on fibrosis-related genes. MATERIALS AND METHODS:By querying PubMed using keywords "fibrosis" and "gene" or "protein," we identified fibrosis-related genes in the last decade. Bi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13008
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To determine the effect of smoking on peptidoglycan recognition protein (PGRP)-1 levels in gingival crevicular fluid (GCF) in smokers and non-smokers with chronic periodontitis (CP) following initial periodontal therapy. SUBJECTS AND METHODS:A total of 40 patients with CP (20 smokers (S + CP) and 20 non-smok...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13207
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate the expression of survivin, an inhibitor of apoptosis, in odontogenic keratocysts and to compare it to the findings in non-neoplastic jaw cysts - periapical cysts, as well as to establish a possible relationship between survivin expression and human cytomegalovirus pr...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01612.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12197
更新日期:2014-11-01 00:00:00