Granzyme B-truncated VEGF fusion protein represses angiogenesis and tumor growth of OSCC.

abstract：BACKGROUND:Increasing evidence indicates that andrographolide (ADG) exhibits anti-cancer activity against various cancer cell lines. However, its high hydrophobicity and poor bioavailability restrict its clinical application as a chemopreventative agent. Previously, we have shown that ADG-loaded solid lipid nanoparticl...

journal_title：Oral diseases

authors： Li H,Qu X,Qian W,Song Y,Wang C,Liu W

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVES:This 6-month prospective clinical study assessed the impacts of Invisalign appliances on the oral bacterial community and oral health of patients. METHODS:Salivary samples were obtained from twenty-five adult patients receiving Invisalign aligner treatment before the treatment (Group B) and at a 6-month fol...

journal_title：Oral diseases

authors： Zhao R,Huang R,Long H,Li Y,Gao M,Lai W

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...

journal_title：Oral diseases

authors： Byun JS,Hong SH,Choi JK,Jung JK,Lee HJ

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:siRNA-induced gene silencing in the salivary gland using microbubble-enhanced sonoporation was used to develop an in vivo gene knockdown technique. METHODS:siRNA targeting rat glyceraldehyde-3-phosphate dehydrogenas (GAPDH) was mixed with echo-enhanced microbubbles and reverse-injected into rat parotid glan...

journal_title：Oral diseases

authors： Sakai T,Kawaguchi M,Kosuge Y

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:To attempt defining differential radiographic diagnostic characteristics for osteonecrotic lesions using 2D as opposed to 3D images. MATERIALS AND METHODS:This was a cross-sectional study. Subjects presenting mandibular osteonecrotic lesions (osteomyelitis, osteoradionecrosis, and medication-related osteonec...

journal_title：Oral diseases

authors： Gaêta-Araujo H,Vanderhaeghen O,Vasconcelos KF,Coucke W,Coropciuc R,Politis C,Jacobs R

更新日期：2021-03-01 00:00:00

abstract：OBJECTIVE:This article sets out to evaluate the prevalence and aetiopathogenesis of edentulism in patients on haemodialysis. SUBJECTS AND METHODS:The study group comprised 44 adult patients with end-stage renal disease (ESRD) on haemodialysis. A control group was formed of 44 individuals matched for age and sex and wi...

journal_title：Oral diseases

authors： Limeres J,Garcez JF,Marinho JS,Loureiro A,Diniz M,Diz P

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in healthy controls towards stimulation to Porphyromonas gingivalis (Pg) and Actinobacillus actinomyce...

journal_title：Oral diseases

authors： Restaíno CG,Chaparro A,Valenzuela MA,Kettlun AM,Vernal R,Silva A,Puente J,Jaque MP,León R,Gamonal J

更新日期：2007-09-01 00:00:00

abstract：:DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Of the all epigenetic modifications, methylation, which represses transcription of the promoter region of tumor suppressor genes leading to gene silencing, ha...

journal_title：Oral diseases

authors： González-Ramírez I,García-Cuellar C,Sánchez-Pérez Y,Granados-García M

更新日期：2011-11-01 00:00:00

abstract：:As the AIDS pandemic has continued, our understanding of the events that occur during the entry and infection of conventional, susceptible cells has increased dramatically, leading to the development of control therapies for HIV-infected individuals. However, an ongoing hole in our understanding is how HIV crosses the...

journal_title：Oral diseases

authors： Moyes DL,Islam A,Kohli A,Naglik JR

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:The molecular mechanisms underlying the development of dysplasia in leukoplakia are unknown. We used RNA sequencing to examine the molecular and biological pathway differences in oral leukoplakia with and without oral epithelial dysplasia. MATERIALS AND METHODS:Excisional biopsy specimens (25) were taken fro...

journal_title：Oral diseases

authors： Farah CS,Fox SA

更新日期：2019-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the effects of various saliva substitutes (Artisial; Glandosane; Oralube; Saliva medac; Oralbalance) on the lesion depth and the mineral content of predemineralized bovine dentin in vitro. MATERIALS AND METHODS:Ninety-six dentin samples were prepared from 24 freshl...

journal_title：Oral diseases

authors： Meyer-Lueckel H,Schulte-Mönting J,Kielbassa AM

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...

journal_title：Oral diseases

authors： Takahashi K,MacDonald D,Murayama Y,Kinane D

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVES:Salivary glands are useful targets for gene therapeutics. After gene transfer into salivary glands, regulated secretory pathway proteins, such as human growth hormone, are secreted into saliva, whereas constitutive secretory pathway proteins, such as erythropoietin, are secreted into the bloodstream. Secreti...

journal_title：Oral diseases

authors： Racz GZ,Zheng C,Goldsmith CM,Baum BJ,Cawley NX

更新日期：2015-03-01 00:00:00

abstract：:Despite the presence of HIV-1 in the oral cavity, transmission of the virus through saliva has not been proven. Consistent with these observations, we recently identified an endogenous 12 kD protein, secretory leukocyte protease inhibitor (SLPI), in saliva which blocks HIV-1 infection in vitro. Whereas other salivary ...

journal_title：Oral diseases

authors： Wahl SM,McNeely TB,Janoff EN,Shugars D,Worley P,Tucker C,Orenstein JM

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of EBV-DNA, CMV-DNA and HPV-DNA in oral healthy mucosa of HIV-infected and renal transplant patients. To associate the detection of viral genomes with laboratory parameters of immunodeficiency, gender, antiretroviral and immunosuppressive therapy. DESIGN:A cross-sectional analysi...

journal_title：Oral diseases

authors： Ammatuna P,Campisi G,Giovannelli L,Giambelluca D,Alaimo C,Mancuso S,Margiotta V

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To review a series of patients with sore, burning mouth treated with alpha-lipoic acid between 2000 and May 2006 and subjectively evaluate improvement in symptoms. DESIGN:Retrospective review of medical records of 195 consecutive patients who sought treatment for sore, burning mouth. Treatment of 47 patients...

journal_title：Oral diseases

authors： Steele JC,Bruce AJ,Drage LA,Rogers RS 3rd

更新日期：2008-09-01 00:00:00

abstract：:The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...

journal_title：Oral diseases

authors： van der Meulen TA,Harmsen H,Bootsma H,Spijkervet F,Kroese F,Vissink A

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...

journal_title：Oral diseases

authors： Bots CP,Poorterman JH,Brand HS,Kalsbeek H,van Amerongen BM,Veerman EC,Nieuw Amerongen AV

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Autosomal-dominant hypocalcified amelogenesis imperfecta (ADHCAI) shows phenotypic heterogeneity. Our aim was to characterise the ADHCAI phenotypes, tooth properties and genotypes. METHODS:Three unrelated ADHCAI probands and seven additional affected members of the three families were recruited. Mutations w...

journal_title：Oral diseases

authors： Sriwattanapong K,Nitayavardhana I,Theerapanon T,Thaweesapphithak S,Chantarawaratit PO,Garuyakich R,Phokaew C,Porntaveetus T,Shotelersuk V

更新日期：2021-01-24 00:00:00

abstract：:This article reviews the recent rapid developments in research that have demonstrated the importance of chemokines and their receptors in HIV infection and the progression to AIDS. These discoveries have transformed our understanding of how the virus may infect cells and why certain individuals may be resistant to HIV...

journal_title：Oral diseases

authors： Thornhill MH,Li J

更新日期：1997-03-01 00:00:00

abstract：OBJECTIVES:To study the response to in vitro priming of peripheral neutrophils from patients with periodontitis compared to healthy controls. Peripheral neutrophils from these patients had shown increased production of oxygen radicals after activation with opsonized bacteria and a difference in priming response could s...

journal_title：Oral diseases

authors： Gustafsson A,Asman B,Bergström K

更新日期：1997-09-01 00:00:00

abstract：:Analysis of the prevalence and incidence of HIV infection globally reveal striking variances with regard to continent, country, region and gender. Of the global total of 33 million people infected with HIV, approximately 65% are in sub-Saharan African countries and 15% in South and South-East Asia with the remaining 2...

journal_title：Oral diseases

authors： Challacombe SJ

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:This review aims to evaluate the efficacy of xenogeneic collagen matrix (XCM) for the treatment of single or multiple gingival recessions in terms of clinical parameters and patient-related outcomes. MATERIALS AND METHODS:Various electronic databases (The Cochrane Central Register of Controlled Trials, MEDL...

journal_title：Oral diseases

authors： Huang JP,Liu JM,Wu YM,Chen LL,Ding PH

更新日期：2019-05-01 00:00:00

abstract：:Studies of the malignant potential of oral lichen planus (OLP) have been hampered by inconsistencies in the diagnostic criteria used for OLP, the criteria adopted to identify a true case of malignant transformation in OLP, the risk factors for malignant transformation and the optimum management of patients to ensure t...

journal_title：Oral diseases

authors： Gonzalez-Moles MA,Scully C,Gil-Montoya JA

更新日期：2008-04-01 00:00:00

abstract：:Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals, thereb...

journal_title：Oral diseases

authors： Wei L,Xu M,Xiong H

更新日期：2020-06-02 00:00:00

abstract：:With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

journal_title：Oral diseases

authors： Zheng LW,Hua H,Cheung LK

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To present a clinical report of palatal zygomycosis, its epidemiological, mycological features, and our treatment experience. DESIGN:Retrospective report. SUBJECTS AND METHODS:This is a 25-year long retrospective trial of clinically and mycologically proven cases of zygomycosis. Some patients underwent a bi...

journal_title：Oral diseases

authors： Bonifaz A,Macias B,Paredes-Farrera F,Arias P,Ponce RM,Araiza J

更新日期：2008-09-01 00:00:00

abstract：:Candidosis is by far the commonest oral fungal infection in man and could manifest as an adverse effect of drug therapy such as inhaled or topically applied corticosteroids. Due to the anti-inflammatory and immunosuppressive effect steroids are used in the management of bronchial asthma and oral mucosal diseases. In t...

journal_title：Oral diseases

authors： Ellepola AN,Samaranayake LP

更新日期：2001-07-01 00:00:00

abstract：:The basic treatment of chronic periodontitis is a mechanical debridement of periodontal pockets by scaling and root planing (S/RP) in combination with efficient plaque control. Locally delivered antiseptics (LDA) have been proposed to practitioners and, while subgingival irrigation of antiseptics is still used in clin...

journal_title：Oral diseases

authors： Etienne D

更新日期：2003-01-01 00:00:00

abstract：:Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...

journal_title：Oral diseases

authors： Green B,Rahimi S,Brennan PA

更新日期：2016-11-01 00:00:00