An update of knowledge on the regulatory role of Treg cells in apical periodontitis.

Abstract:

:Apical periodontitis (AP) is a prevalent infectious and inflammatory disorder that involves inflammation of periapical tissues and the disintegration of alveolar bone. AP may eventually lead to tooth loss if not timely treated. This disease is caused by pathogenic bacteria in the necrotic pulps and root canals, thereby triggering responses from the innate and adaptive immune system of the periapical tissues. Regulatory T (Treg) cells play a major role in maintaining immune homoeostasis and immunological self-tolerance; however, these only account for roughly 5%-10% of human peripheral CD4+ T cells. Several studies have examined the possible role and underlying mechanism of Treg cells in different inflammatory and autoimmune disorders to facilitate the development of novel treatments for these diseases. Recent studies have indicated that Treg cells may gather at the sites of infection, thus limiting the generation of immune responses and bone resorption in the periapical area. This review will summarize studies regarding the presence and regulatory role of Treg cells in AP.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Wei L,Xu M,Xiong H

doi

10.1111/odi.13450

subject

Has Abstract

pub_date

2020-06-02 00:00:00

eissn

1354-523X

issn

1601-0825

pub_type

杂志文章,评审
  • The PI3K/Akt/mTOR axis in head and neck cancer: functions, aberrations, cross-talk, and therapies.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is one of the most morbid, mortal, and genetically diverse malignancies. Although HNSCC is heterogeneous in nature, alterations in major components of the PI3K/Akt/mTOR pathway are consistently observed throughout the majority of HNSCC cases. These alterations include gene...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12206

    authors: Vander Broek R,Mohan S,Eytan DF,Chen Z,Van Waes C

    更新日期:2015-10-01 00:00:00

  • Panoramic radiography measurements, osteoporosis diagnoses and fractures in Japanese men and women.

    abstract:OBJECTIVES:The purpose of this study was to investigate the association of the shape of the mandibular cortex on panoramic radiographs with the risk of an osteoporosis diagnosis without prevalent fractures and with the risk of osteoporotic fractures in Japanese men and women. SUBJECTS AND METHODS:One thousand and twen...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12282

    authors: Yamada S,Uchida K,Iwamoto Y,Sugino N,Yoshinari N,Kagami H,Taguchi A

    更新日期:2015-04-01 00:00:00

  • HIV infection and periodontal diseases: an overview of the post-HAART era.

    abstract::HIV infection remains a global health problem of unprecedented dimensions, although the development of highly active antiretroviral therapy (HAART) has significantly modified the course of HIV disease into a manageable chronic disease with longer survival and improved quality of life in HIV-infected subjects. Among th...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01727.x

    authors: Mataftsi M,Skoura L,Sakellari D

    更新日期:2011-01-01 00:00:00

  • Orofacial granulomatosis--a 20-year review.

    abstract::Orofacial granulomatosis (OFG) is the presence of persistent enlargement of the soft tissues of the oral and maxillofacial region, characterized by non-caseating granulomatous inflammation in the absence of diagnosable systemic Crohn's disease (CD) or sarcoidosis. Over 20 years have passed since OFG was first describe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2008.01500.x

    authors: Grave B,McCullough M,Wiesenfeld D

    更新日期:2009-01-01 00:00:00

  • Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws.

    abstract:OBJECTIVES:To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN:Retrospective case review. METHODS:The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2008.01494.x

    authors: Treister N,Sheehy N,Bae EH,Friedland B,Lerman M,Woo S

    更新日期:2009-01-01 00:00:00

  • Prevalence of hepatitis virus infection in association with oral diseases requiring surgery.

    abstract:OBJECTIVE:We evaluated the prevalence of hepatitis virus infection in a large population of patients in terms of diseases requiring oral surgery. DESIGN:Retrospective case survey. SUBJECTS AND METHODS:Prevalence of hepatitis B and C virus (HBV, HCV) infection were compared between oral diseases such as inflammation, ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2002.1o794.x

    authors: Takata Y,Takahashi T,Fukuda J

    更新日期:2002-03-01 00:00:00

  • Traditional Chinese medicine and oral diseases: today and tomorrow.

    abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01706.x

    authors: Zheng LW,Hua H,Cheung LK

    更新日期:2011-01-01 00:00:00

  • Toward gene therapy for growth hormone deficiency via salivary gland expression of growth hormone.

    abstract:OBJECTIVES:Salivary glands are useful targets for gene therapeutics. After gene transfer into salivary glands, regulated secretory pathway proteins, such as human growth hormone, are secreted into saliva, whereas constitutive secretory pathway proteins, such as erythropoietin, are secreted into the bloodstream. Secreti...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12217

    authors: Racz GZ,Zheng C,Goldsmith CM,Baum BJ,Cawley NX

    更新日期:2015-03-01 00:00:00

  • Micronuclear and sister chromatid exchange analyses in peripheral lymphocytes of patients with oral lichen planus--a pilot study.

    abstract:OBJECTIVE:The purpose of this study was to determine the genetic instability of peripheral blood lymphocytes from patients diagnosed with oral lichen planus (OLP) by investigation of frequencies of micronuclei (MN) and sister chromatid exchange (SCE). MATERIALS AND METHODS:A total of 22 newly diagnosed and untreated p...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2009.01576.x

    authors: Ergun S,Warnakulasuriya S,Duman N,Saruhanoğlu A,Sevinç B,Oztürk S,Ozel S,Cefle K,Palanduz S,Tanyeri H

    更新日期:2009-10-01 00:00:00

  • Local drug delivery for oral mucosal diseases: challenges and opportunities.

    abstract::There are few topical formulations used for oral medicine applications most of which have been developed for the management of dermatological conditions. As such, numerous obstacles are faced when utilizing these preparations in the oral cavity, namely enzymatic degradation, taste, limited surface area, poor tissue pe...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2011.01793.x

    authors: Sankar V,Hearnden V,Hull K,Juras DV,Greenberg MS,Kerr AR,Lockhart PB,Patton LL,Porter S,Thornhill M

    更新日期:2011-04-01 00:00:00

  • Salivary gland malignancies - an update on current management for oral healthcare practitioners.

    abstract::Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12498

    authors: Green B,Rahimi S,Brennan PA

    更新日期:2016-11-01 00:00:00

  • Clinical and genetic analysis of patients with cherubism.

    abstract:OBJECTIVE:To describe the clinical and genetic features of patients with cherubism. MATERIAL AND METHODS:A descriptive analysis of 14 cases from nine different families was carried out. Clinicopathological, imaging, and follow-up data were retrieved from patients' medical files and correlated with the genetic profile ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12705

    authors: Machado RA,Pontes H,Pires FR,Silveira HM,Bufalino A,Carlos R,Tuji FM,Alves D,Santos-Silva AR,Lopes MA,Capistrano HM,Coletta RD,Fonseca FP

    更新日期:2017-11-01 00:00:00

  • The paradox of painless periodontal disease.

    abstract::Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12537

    authors: Gaurilcikaite E,Renton T,Grant AD

    更新日期:2017-05-01 00:00:00

  • Serum microRNAs as potential biomarkers of mandibular prognathism.

    abstract:OBJECTIVES:The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP). METHODS:Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12073

    authors: Gu Y,Zhang Y,Zhao C,Pan Y,Smales RJ,Wang H,Ni Y,Zhang H,Ni J,Ma J,Wang L

    更新日期:2014-01-01 00:00:00

  • Novel anticoagulants: general overview and practical considerations for dental practitioners.

    abstract::Currently, 4 novel Direct Oral Anticoagulants (DOACs) were approved by the FDA. This review focuses on these agents and proposes a matrix for the general dentists to assess bleeding risk in dental management of patient on DOACs. The outline covers the pharmacology of DOACs (rivaroxaban, apixaban, edoxaban and dabigatr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12371

    authors: Elad S,Marshall J,Meyerowitz C,Connolly G

    更新日期:2016-01-01 00:00:00

  • Current and historical involvement of dentistry in child protection and a glimpse of the future.

    abstract::Dental teams have been involved with child protection for over 40 years. This brief review summarises their involvement in the detection of various types of child abuse and goes on to discuss the gap between the proportions of dental professionals who suspect child abuse or neglect in their paediatric patients and tho...

    journal_title:Oral diseases

    pub_type: 历史文章,杂志文章,评审

    doi:10.1111/odi.12485

    authors: Park CM,Welbury R

    更新日期:2016-10-01 00:00:00

  • The effect of sodium lauryl sulphate, triclosan and zinc on the permeability of normal oral mucosa.

    abstract:OBJECTIVE:Sodium lauryl sulphate (SLS), an important component in many oral health products, is well established as a contact irritant in skin. Recent studies have suggested that it may also affect the structural integrity of oral mucosa. SLS is rarely used alone in dentifrices or mouthwashes and the aim of this study ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2000.tb00112.x

    authors: Healy CM,Cruchley AT,Thornhill MH,Williams DM

    更新日期:2000-03-01 00:00:00

  • Immunohistochemistry and gene expression of GLUT1, RUNX2 and MTOR in reparative dentinogenesis.

    abstract:OBJECTIVES:To determine glucose transporter 1 (GLUT1) and runt-related transcription factor 2 (RUNX2) expression during reparative dentinogenesis after pulpotomy with mineral trioxide aggregate (MTA) capping. SUBJECTS AND METHODS:Eight-week-old male Wistar rats were used. Pulp of the upper left first molar was exposed...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13230

    authors: Takeuchi R,Ohkura N,Yoshiba K,Tohma A,Yoshiba N,Edanami N,Shirakashi M,Belal RS,Ohshima H,Noiri Y

    更新日期:2020-03-01 00:00:00

  • The soft connective tissues of the gingiva and periodontal ligament: are they unique?

    abstract::The connective tissues of the gingiva and periodontal ligament share a common embryonic development from cells of the cranial neural crest. This review paper describes the relationship of these tissues in tooth germ initiation, development and eruption. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1995.tb00188.x

    authors: Palmer RM,Lubbock MJ

    更新日期:1995-12-01 00:00:00

  • Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.

    abstract::Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12722

    authors: Li J,Ke X,Yan F,Lei L,Li H

    更新日期:2018-09-01 00:00:00

  • Emerging and changing viral diseases in the new millennium.

    abstract::Most viral infections encountered in resource-rich countries are relatively trivial and transient with perhaps fever, malaise, myalgia, rash (exanthema) and sometimes mucosal manifestations (enanthema), including oral in some. However, the apparent benignity may be illusory as some viral infections have unexpected con...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12356

    authors: Scully C,Samaranayake LP

    更新日期:2016-04-01 00:00:00

  • Clinical, microbiological and ultrastructural features of angular cheilitis lesions in Southern Chinese.

    abstract:OBJECTIVE:To obtain baseline data on angular cheilitis in Southern Chinese. DESIGN:A cross-sectional investigation of the clinical, microbiological and ultrastructural features of the condition. SUBJECTS AND METHOD:Thirty six Chinese adults with angular cheilitis; 28 controls matched for age and sex, with no inflamma...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1995.tb00156.x

    authors: Dias AP,Samaranayake LP

    更新日期:1995-03-01 00:00:00

  • Effect of aluminum concentration on dental caries formation in the rat.

    abstract:OBJECTIVE:Topically applied aluminum (AI) reduced fissure caries in rats with indigenous microflora, but neither therapeutic activity nor concentration effects have been studied in animals infected with caries-inducing bacteria. This study investigated the effects of solutions containing various AI concentrations on fo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.1995.tb00164.x

    authors: Putt MS,Kleber CJ

    更新日期:1995-06-01 00:00:00

  • Efficacy of short-term adjunctive subantimicrobial dose doxycycline in diabetic patients--randomized study.

    abstract:OBJECTIVE:To investigate the effectiveness of short-term adjunctive subantimicrobial dose doxycycline (SDD) treatment in patients with diabetes mellitus type 2 and chronic periodontitis (CP). METHODS:Thirty-four patients with CP and type 2 diabetes mellitus were included in the placebo-controlled, double-blind study. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1601-0825.2012.01943.x

    authors: Gilowski L,Kondzielnik P,Wiench R,Płocica I,Strojek K,Krzemiński TF

    更新日期:2012-11-01 00:00:00

  • Evaluation of modified cold-atmospheric pressure plasma (MCAP) for the treatment of peri-implantitis in beagles.

    abstract:OBJECTIVE:To assess the effect of adjunctive use of modified cold-atmospheric pressure plasma (MCAP) to surgically mechanical debridement (MD) on peri-implantitis (PI) in beagles. MATERIAL AND METHODS:Bilateral mandibles of beagles with PI, which induced by cotton ligature twined with steel in sub-marginal around the ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13757

    authors: Zhou X,Wu D,Liang D,Zhang W,Shi Q,Cao Y

    更新日期:2020-12-15 00:00:00

  • Oral colonization by Candida species in AIDS pediatric patients.

    abstract::The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by rela...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2010.01765.x

    authors: Domaneschi C,Massarente DB,de Freitas RS,de Sousa Marques HH,Paula CR,Migliari DA,Antunes JL

    更新日期:2011-05-01 00:00:00

  • RT-PCR quantification of periodontal pathogens in crack users and non-users.

    abstract:OBJECTIVE:To compare counts of Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis and Fusobacterium nucleatum between crack users and non-users. MATERIALS AND METHODS:A cross-sectional study was conducted involving seventy-four crack cocaine users and eighty-one non-users matched fo...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12609

    authors: Casarin M,Antoniazzi RP,Vaucher RA,Feldens CA,Zanatta FB

    更新日期:2017-04-01 00:00:00

  • The association between serum 25-hydroxyvitamin D levels and dental caries in US adults.

    abstract:OBJECTIVES:We investigated whether 25-hydroxyvitamin D concentration is independently associated with dental caries among adults in the United States. SUBJECTS AND METHODS:This investigation was a cross-sectional study. A total of 4,244 participants (aged 20-80 years) were enrolled through the 2007-2008 National Healt...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13360

    authors: Zhou F,Zhou Y,Shi J

    更新日期:2020-10-01 00:00:00

  • Periodontitis aggravates renal inflammatory response in a mouse model of renal fibrosis.

    abstract:OBJECTIVES:To assess the effects of periodontitis on renal interstitial fibrosis in a mouse model. MATERIALS AND METHODS:Thirty C57BL/6 male mice were divided into control, periodontitis (PD), unilateral ureteral ligation (UUO) and PD+UUO groups. Unilateral ureteral ligation was performed 6 days after periodontitis. A...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13764

    authors: Bi C,Han XL,Li XZ,Sun JY,Liu Y,Duan SZ,Lu HX

    更新日期:2020-12-31 00:00:00

  • Oral lichenoid lesions of the upper lip and gingiva: What we know so far.

    abstract::The clinical presentation of oral lichen planus and oral lichenoid lesions is diverse. A special category of patients presents with lichenoid lesions affecting only the mucosa of their upper lip and the anterior upper gingiva. This is a concise review summarizing the specific characteristics of these patients. ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12763

    authors: Georgakopoulou EA,Malamos D,Achtari MD

    更新日期:2018-03-01 00:00:00