Abstract:
:Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly neutrophils and monocytes into the gingival sulcus or the periodontal pocket. Moreover, dysbiosis with overgrowth of anaerobic pathogens, such as Porphyromonas gingivalis and Tannerella forsythia, may induce death of both immune cells and host resident cells. Necroptosis is one newly characterized programmed cell death mediated by receptor-interacting protein kinase (RIPK)-1, RIPK3, and mixed lineage kinase like (MLKL). With its release of death-associated molecular patterns (DAMPs) into extracellular environment, necroptosis may help transmit the danger signal and amplify the inflammatory responses. In this review, we present recent advances on how necroptosis influences bacterial infection progression and what a role necroptosis plays in maintaining the homeostasis in the periodontal niche. Until we fully decipher the signals emanated from dying cells, we cannot completely understand the mechanism of disease progression.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Li J,Ke X,Yan F,Lei L,Li Hdoi
10.1111/odi.12722subject
Has Abstractpub_date
2018-09-01 00:00:00pages
900-907issue
6eissn
1354-523Xissn
1601-0825journal_volume
24pub_type
杂志文章,评审相关文献
ORAL DISEASES文献大全abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12197
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVES:The role of radiotherapy (RT) for oligometastases is currently established in different oncological settings but data on salivary gland cancer (SGC) are lacking. We evaluated the role of RT in oligometastatic SGC patients, focusing on stereotactic body radiation therapy (SBRT). MATERIALS AND METHODS:We perf...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13755
更新日期:2020-12-15 00:00:00
abstract:BACKGROUND:Overexpression of fatty acid synthase (FAS), the cytosolic enzyme responsible for the conversion of dietary carbohydrates to fatty acids, has been reported in several human malignancies and pointed as a potential prognostic marker for some tumors. This study investigated whether FAS immunohistochemical expre...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2007.01395.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the prevalence of areca nut consumption and to identify social and behavioural determinants among a Taiwanese adolescent population. SUBJECTS AND METHODS:A random sample of 5,343 high school students aged between 15-18 years in Kaohsiung, Taiwan, participated in the study. Par...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13467
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the oral functionality and the oral sensorimotor alterations are associated with oropharyngeal dysphagia in community-dwelling older persons and long-term care older residents. METHODS:An exploratory study with 265 independent older persons of the southern state of Brazil. The diagnosis o...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12809
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:Members of the family of matrix metalloproteinases (MMPs; also called collagenases or matrixins) are key enzymes in matrix degradation. They function at neutral pH and can digest synergistically all the matrix macromolecules. Biochemical and clonal studies indicate that there are three major groups: the spec...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1996.tb00206.x
更新日期:1996-03-01 00:00:00
abstract:OBJECTIVES:Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe complication of systemic nitrogen-containing bisphosphonate (N-BP) administration, which leads to osteonecrosis, pain, and infection. Despite much effort, effective remedies are yet to be established. This study aimed to investigate potentia...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13436
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-α at positions -863, -308 and -238 which have putative functional significances. MATERIALS AND METHODS: Genomic DNA from 75 Tha...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2010.01722.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:X-linked hypohidrotic ectodermal dysplasia (XLHED) is characterized by abnormalities of hair, teeth, and sweat glands, while non-syndromic hypodontia (NSH) affects only teeth. Mutations in Ectodysplasin A (EDA) underlie both XLHED and NSH. This study investigated the genetic causes of six hypohidrotic ectode...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12376
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Mandibular osteoradionecrosis (ORN) is a devastating complication secondary to the radiotherapy of head and neck cancer. The nutritional status of ORN patients is compromised, but remains rarely studied. We aimed to evaluate the overall nutritional status of patients with ORN and explore the risk factors beh...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13762
更新日期:2020-12-28 00:00:00
abstract:OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were per...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13437
更新日期:2020-11-01 00:00:00
abstract::Elder neglect (EN) is the failure of a designated caregiver to meet the needs of a dependent older person. World EN prevalence, meta-analyzed in this study, is 1.0% or 1.8% according to different statistical methods. Referring alleged EN cases to Adult Protective Services (APSs) by healthcare workers (HCWs) is mandato...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12797
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Prognosis of patients with head and neck squamous cell carcinoma (HNSCC) is still poor. Novel therapeutic approaches are of great interest to improve the effects of radiochemotherapy. We evaluated the effects of tyrosine kinase inhibitor neratinib on HNSCC cell lines CAL27, SCC25 and FaDu as a single agent an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12552
更新日期:2016-11-01 00:00:00
abstract::Over the last thirty years, the human immunodeficiency virus (HIV) epidemic has matured. In the United States, HIV has changed from an explosive outbreak to an endemic disease; currently, an estimated 1.1 million people are infected with HIV, including a substantial number who are unaware of their status. With recent ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12047
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:The role of structural and host defensive cells in periapical lesions has been assessed previously by morphometric and immunohistochemical studies. The aim of this study was to investigate the function of peri- apical cells by employing molecular techniques to estimate the cell synthetic activity, proliferati...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1999.tb00096.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVES:We investigated whether 25-hydroxyvitamin D concentration is independently associated with dental caries among adults in the United States. SUBJECTS AND METHODS:This investigation was a cross-sectional study. A total of 4,244 participants (aged 20-80 years) were enrolled through the 2007-2008 National Healt...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13360
更新日期:2020-10-01 00:00:00
abstract::The connective tissues of the gingiva and periodontal ligament share a common embryonic development from cells of the cranial neural crest. This review paper describes the relationship of these tissues in tooth germ initiation, development and eruption. ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1995.tb00188.x
更新日期:1995-12-01 00:00:00
abstract::Salivary gland tumours represent a diverse range of tumours with many histological subtypes which occur in major and minor salivary glands. The management of these tumours is complex owing to their heterogeneity. Surgery together with radiotherapy and/or chemotherapy remains the treatment strategy for these tumours. T...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12498
更新日期:2016-11-01 00:00:00
abstract:BACKGROUND:Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. METHODS:Databases including Ovid MEDLINE, ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13671
更新日期:2020-10-08 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine the correlation between the number of FOXP3(+) T cell in lesions and the disease activity of patients with oral lichen planus (OLP). MATERIALS AND METHODS:The expression of FOXP3 was investigated using immunohistochemical staining and real-time RT-PCR in 23 OLP lesions ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01608.x
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To study the incidence and magnitude of bacteremia after dental extraction and supragingival scaling. SUBJECTS AND METHODS:Blood samples were taken before and 5 and 30 min after dental extraction and supragingival scaling from individuals at high (n = 44) or negligible risk (n = 51) for infective endocarditi...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12792
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:Non-syndromic cleft lip, with or without cleft palate (NSCL/P), is a common craniofacial birth defect, the risk of which is influenced from multiple genetic loci. Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P have been incon...
journal_title:Oral diseases
pub_type: 杂志文章,meta分析,评审
doi:10.1111/odi.13127
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVES:The establishment of animal models of xenotransplantation can contribute to the elucidation of the molecular pathogenesis of ameloblastic fibrodentinomas (AFD) and it also provides an opportunity for drug tests. We aimed to evaluate the possibility of AFD tumour growth in a patient-derived xenograft (PDX) mo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13056
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To document the pattern of intra-oral carcinomas diagnosed in north-eastern Nigeria. DESIGN AND SETTING:A retrospective clinical and histopathological review seen in a tertiary care hospital (January 1987-December 2002). MATERIALS AND METHODS:Information on socio-demographic characteristics of patients and ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2005.01134.x
更新日期:2005-11-01 00:00:00
abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.1997.tb00361.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. METHODS:A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting ...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12113
更新日期:2014-04-01 00:00:00
abstract::Cannabis, also known as marijuana, is one of the most commonly used substances for medical and recreational purposes globally. With the trend of global legalization of medical use of cannabis and even the recreational use, the prevalence of recreational use of cannabis has increased markedly over the past few years. C...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13246
更新日期:2020-10-01 00:00:00
abstract::Periodontal diseases, primarily gingivitis and periodontitis, are characterised by progressive inflammation and tissue destruction. However, they are unusual in that they are not also accompanied by the pain commonly seen in other inflammatory conditions. This suggests that interactions between periodontal bacteria an...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12537
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:Patients with burning mouth syndrome (BMS) often represent a clinical challenge as available agents for symptomatic treatment are few and often ineffective. The aim was to evaluate the effect of a bupivacaine lozenge on oral mucosal pain, xerostomia, and taste alterations in patients with BMS. METHODS:Eighte...
journal_title:Oral diseases
pub_type: 杂志文章,随机对照试验
doi:10.1111/odi.12386
更新日期:2016-03-01 00:00:00
abstract::The aim of this study was to assess the prevalence of factors associated with oral colonization by Candida spp. in pediatric patients with AIDS. The sample comprised of 117 children. Clinical status, medicines in use, and laboratory findings were obtained from hospital records; sociodemographic data were given by rela...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2010.01765.x
更新日期:2011-05-01 00:00:00