MSX1 gene polymorphisms and non-syndromic cleft lip with or without palate (NSCL/P): A meta-analysis.

Abstract:

OBJECTIVE:Non-syndromic cleft lip, with or without cleft palate (NSCL/P), is a common craniofacial birth defect, the risk of which is influenced from multiple genetic loci. Association study outcomes between single nucleotide polymorphisms (SNPs) near the muscle segment homeobox gene 1 (MSX1) and NSCL/P have been inconsistent. This compels a meta-analysis to obtain more precise estimates. METHODS:From 15 publications, we examined 12 SNPs under six groups (SG), based on linkage disequilibrium. Pooled odds ratios and 95% confidence intervals were calculated under the standard genetic models. The pooled effects were subjected to subgroup, outlier, sensitivity, and funnel plot (publication bias) analyses. RESULTS:Three of the six SGs showed significant associations. SG1 and SG4 effects indicated reduced risks. SG1 outcomes were attributed to outlier treatment, which the Asian outcomes validated. In contrast, increased risks were observed in SG3. All these significant outcomes were deemed robust by sensitivity analysis with no evidence of publication bias. CONCLUSIONS:Our study shows eight MSX1 SNPs associated with risk of NSCL/P. SG1 and SG4 carriers are protected (up to 23%), but SG3 carriers are 1.3-fold susceptible. Outlier treatment unmasked the significant associations in SG1. Non-heterogeneity and robustness helped elevate the level of evidence in our significant findings.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Tasanarong P,Pabalan N,Tharabenjasin P,Jarjanazi H

doi

10.1111/odi.13127

subject

Has Abstract

pub_date

2019-09-01 00:00:00

pages

1492-1501

issue

6

eissn

1354-523X

issn

1601-0825

journal_volume

25

pub_type

杂志文章,meta分析,评审
  • Clinical evaluation of salivary carbohydrate antigen 125 and leptin in controls and parotid tumours.

    abstract:OBJECTIVES:We determined the correlation between saliva and serum for CA125 and leptin, and evaluated their clinical screening potential for parotid tumours. SUBJECTS AND METHODS:Serum, acid-stimulated bilateral parotid saliva and chewing-stimulated whole saliva were collected and measured the levels of CA125 and lept...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12505

    authors: Zhang KY,Liu CY,Hua L,Wang SL,Li J

    更新日期:2016-10-01 00:00:00

  • MicroRNA-21 promotes orthodontic tooth movement by modulating the RANKL/OPG balance in T cells.

    abstract:OBJECTIVES:The present study was designed to investigate the effects of microRNA-21 (miR-21) on orthodontic tooth movement. METHODS:The orthodontic tooth movement model was established in C57BL/6 and miR-21-/- mice with or without implantation of activated T cells. Histological and histomorphometrical analyses were pe...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13239

    authors: Wu L,Su Y,Lin F,Zhu S,Wang J,Hou Y,Du J,Liu Y,Guo L

    更新日期:2020-03-01 00:00:00

  • Usefulness of intra-oral ultrasonography to predict neck metastasis in patients with tongue carcinoma.

    abstract:OBJECTIVE:To assess tissue characterization relating with neck metastasis of invasive tongue cancer, we investigate the usefulness of intra-oral ultrasonography (US). MATERIALS AND METHODS:The patients with squamous cell carcinoma of the tongue (n = 110) were preoperatively evaluated with intra-oral US. The US images ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2007.01423.x

    authors: Natori T,Koga M,Anegawa E,Nakashima Y,Tetsuka M,Yoh J,Kusukawa J

    更新日期:2008-10-01 00:00:00

  • Sex differences in the hypothalamic-pituitary-adrenal axis in patients with burning mouth syndrome.

    abstract:OBJECTIVE:To investigate the sex differences in clinical features, including salivary flow rate, psychological distress and hypothalamic-pituitary-adrenal axis response and their inter-relationships in patients with burning mouth syndrome. SUBJECTS AND METHODS:Eighteen men and 37 postmenopausal women with burning mout...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13195

    authors: Lee YH,An JS,Chon S

    更新日期:2019-11-01 00:00:00

  • Influence of gender and stress on the volatile sulfur compounds and stress biomarkers production.

    abstract:BACKGROUND:Stress and menstrual cycle have been described as factors influencing bad breath, as they can alter oral homeostasis and contribute to the production of volatile sulfur compounds (VSC). OBJECTIVE:Considering that the experimenter's and volunteer's gender may influence the volunteer's responses to stress, th...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12011

    authors: Lima PO,Calil CM,Marcondes FK

    更新日期:2013-05-01 00:00:00

  • YouTube as a source of information on mouth (oral) cancer.

    abstract:OBJECTIVES:We examined the content of YouTube(™) videos on mouth (oral) cancer and evaluated their usefulness in promoting early detection of oral cancer. MATERIALS AND METHODS:A systematic search of YouTube(™) for videos containing information on mouth cancer was conducted using the keywords 'mouth cancer' and 'oral ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12434

    authors: Hassona Y,Taimeh D,Marahleh A,Scully C

    更新日期:2016-04-01 00:00:00

  • Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain.

    abstract:OBJECTIVE:To examine whether transient receptor potential vanilloid 2 (TRPV2) contributes to the changes in intra-oral thermal and mechanical sensitivity following the incision of buccal mucosa. MATERIALS AND METHODS:Buccal mucosal pain threshold was measured after the incision. Changes in the number of TRPV2-immunore...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12853

    authors: Urata K,Shinoda M,Ikutame D,Iinuma T,Iwata K

    更新日期:2018-09-01 00:00:00

  • Increased oral inflammation, leukocytes, and leptin, and lower adiponectin in overweight or obesity.

    abstract:OBJECTIVES:The association between body mass index (BMI) and oral diseases was investigated, and levels of obesity-related inflammatory mediators were evaluated. SUBJECTS AND METHODS:Participants (n = 160) were clinically and radiographically examined for oral diseases. Blood profiles were recorded. Levels of adiponec...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12679

    authors: Thanakun S,Pornprasertsuk-Damrongsri S,Izumi Y

    更新日期:2017-10-01 00:00:00

  • Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature.

    abstract:OBJECTIVE:Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insi...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13145

    authors: Rahajoe PS,Smit MJ,Kertia N,Westra J,Vissink A

    更新日期:2019-09-01 00:00:00

  • Solubility properties of human tooth mineral and pathogenesis of dental caries.

    abstract::Dental research over the last century has advanced our understanding of the etiology and pathogenesis of caries lesions. Increasing knowledge of the dynamic demineralization/remineralization processes has led to the current consensus that bacteria-mediated tooth destruction can be arrested or even to some degree rever...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2004.01030.x

    authors: Aoba T

    更新日期:2004-09-01 00:00:00

  • Sentinels and signposts: the epidemiology and significance of the oral manifestations of HIV disease.

    abstract::A large number of studies attest to the frequency of oral disease in those with HIV infection. Most show that hairy leukoplakia and pseudomembranous candidiasis are the commonest lesions in those with HIV infection and AIDS, with higher prevalence and incidence rates correlating with falling CD4 counts and disease pro...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00344.x

    authors: Greenspan JS

    更新日期:1997-05-01 00:00:00

  • Collagenases and tissue inhibitors of metalloproteinases: a functional balance in tissue degradation.

    abstract:BACKGROUND:Members of the family of matrix metalloproteinases (MMPs; also called collagenases or matrixins) are key enzymes in matrix degradation. They function at neutral pH and can digest synergistically all the matrix macromolecules. Biochemical and clonal studies indicate that there are three major groups: the spec...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1996.tb00206.x

    authors: Reynolds JJ

    更新日期:1996-03-01 00:00:00

  • Serum microRNAs as potential biomarkers of mandibular prognathism.

    abstract:OBJECTIVES:The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP). METHODS:Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12073

    authors: Gu Y,Zhang Y,Zhao C,Pan Y,Smales RJ,Wang H,Ni Y,Zhang H,Ni J,Ma J,Wang L

    更新日期:2014-01-01 00:00:00

  • Surface properties of lactobacilli isolated from healthy subjects.

    abstract:OBJECTIVE:Lactobacilli are considered cariogenic micro-organisms. As oral species of lactobacilli have not been thoroughly described, the aim of this work was to isolated and identify these organisms from teeth, tongue, saliva and gum of healthy patients and to describe some of their surface properties. SUBJECTS:Forty...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2000.tb00118.x

    authors: Colloca ME,Ahumada MC,López ME,Nader-Macías ME

    更新日期:2000-07-01 00:00:00

  • The microbiome-systemic diseases connection.

    abstract::The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12472

    authors: van der Meulen TA,Harmsen H,Bootsma H,Spijkervet F,Kroese F,Vissink A

    更新日期:2016-11-01 00:00:00

  • The deep mycoses in HIV infection.

    abstract::The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infecte...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.1997.tb00361.x

    authors: Scully C,de Almeida OP,Sposto MR

    更新日期:1997-05-01 00:00:00

  • The oral health status of dentate patients with chronic renal failure undergoing dialysis therapy.

    abstract:OBJECTIVE:The aim of this study was to compare the oral health status of chronic renal failure (CRF) patients on renal replacement therapy with a matched reference population. DESIGN:Cross-sectional study. SUBJECTS:Forty-two dentate CRF patients--aged 25-52 years old--were matched with a reference group of 808 dentat...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2005.01183.x

    authors: Bots CP,Poorterman JH,Brand HS,Kalsbeek H,van Amerongen BM,Veerman EC,Nieuw Amerongen AV

    更新日期:2006-03-01 00:00:00

  • Prevalence and classification of HIV-associated oral lesions.

    abstract:OBJECTIVES:An International Workshop addressed the prevalence and classification of HIV/ AIDS associated oral lesions. DESIGN:Five questions provided the framework for discussion and literature review. What is the prevalence of oral lesions in children and adults? Should the accepted classification of HIV-related oral...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1034/j.1601-0825.2002.00020.x

    authors: Patton LL,Phelan JA,Ramos-Gomez FJ,Nittayananta W,Shiboski CH,Mbuguye TL

    更新日期:2002-01-01 00:00:00

  • Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

    abstract:OBJECTIVE:Transforming growth factor-beta (TGF-β) proteins are involved in epithelial keratinization. The major function of latent TGF-β binding proteins (LTBPs) is modulating TGF-β activity. However, whether LTBP-1 and LTBP-2 play roles in gingiva keratinization remains unclear. MATERIALS AND METHODS:Human keratinize...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12344

    authors: Chiang MS,Yang JR,Liao SC,Hsu CC,Hsu CW,Yuan K

    更新日期:2015-09-01 00:00:00

  • Hyperbaric oxygen therapy and osteonecrosis.

    abstract::Osteonecrosis of the jaw may be caused by radiation, medication, or infection. Optimal therapy requires a multimodal approach that combines surgery with adjuvant treatments. This review focuses on the use of adjunctive hyperbaric oxygen therapy for this condition. In addition to evidence regarding the basic and clinic...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12489

    authors: Ceponis P,Keilman C,Guerry C,Freiberger JJ

    更新日期:2017-03-01 00:00:00

  • Necroptosis in the periodontal homeostasis: Signals emanating from dying cells.

    abstract::Periodontal tissues are constantly exposed to microbial stimuli. The equilibrium between microbes and host defense system helps maintain the homeostasis in the periodontal microenvironment. Growth of pathogenic bacteria in dental biofilms may induce proinflammatory cytokine production to recruit sentinel cells, mainly...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12722

    authors: Li J,Ke X,Yan F,Lei L,Li H

    更新日期:2018-09-01 00:00:00

  • Antibiotic effects on bacterial profile in osteonecrosis of the jaw.

    abstract:OBJECTIVE:Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ), and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues. MATERIALS ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2011.01848.x

    authors: Ji X,Pushalkar S,Li Y,Glickman R,Fleisher K,Saxena D

    更新日期:2012-01-01 00:00:00

  • Aloe vera herbal dentifrices for plaque and gingivitis control: a systematic review.

    abstract:OBJECTIVES:To evaluate the effectiveness of aloe vera containing herbal dentifrices in improving plaque control and gingival health. METHODS:A manual and electronic literature (MEDLINE and Cochrane Central Register of Controlled Trials) search was performed up to July 2012, for randomized controlled trials presenting ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.12113

    authors: Dhingra K

    更新日期:2014-04-01 00:00:00

  • Traditional Chinese medicine and oral diseases: today and tomorrow.

    abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/j.1601-0825.2010.01706.x

    authors: Zheng LW,Hua H,Cheung LK

    更新日期:2011-01-01 00:00:00

  • Rehabilitation of lost teeth related to maintenance of cognitive function.

    abstract:OBJECTIVE:As the era of aging comes, cognitive impairment (CI) is increasing. The impact of rehabilitation of lost tooth on CI remains unclear. This study aimed to investigate whether non-rehabilitated lost teeth (NRLT) is associated with CI among Korean elders. METHODS:A total of 280 elders comprising of 140 cases an...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.12960

    authors: Shin MS,Shin YJ,Karna S,Kim HD

    更新日期:2019-01-01 00:00:00

  • Development of novel oligonucleotide probes for seven Actinomyces species and their utility in supragingival plaque analysis.

    abstract:OBJECTIVE:The traditional, biochemical and enzymatic methods of identifying Actinomyces species are frequently confounded by the similar phenotypic characteristics shared by the different members of this genus. Therefore, we developed novel species-specific oligonucleotide probes to accurately speciate seven pathogenic...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1034/j.1601-0825.2003.02926.x

    authors: Tang G,Yip HK,Luo G,Cheung BP,Shen S,Samaranayake LP

    更新日期:2003-07-01 00:00:00

  • Dental panoramic radiographic evaluation in bisphosphonate-associated osteonecrosis of the jaws.

    abstract:OBJECTIVES:To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN:Retrospective case review. METHODS:The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2008.01494.x

    authors: Treister N,Sheehy N,Bae EH,Friedland B,Lerman M,Woo S

    更新日期:2009-01-01 00:00:00

  • The budding and depth of invasion model in oral cancer: A systematic review and meta-analysis.

    abstract:BACKGROUND:Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta-analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC. METHODS:Databases including Ovid MEDLINE, ...

    journal_title:Oral diseases

    pub_type: 杂志文章,评审

    doi:10.1111/odi.13671

    authors: Wahab A,Onkamo O,Pirinen M,Almangush A,Salo T

    更新日期:2020-10-08 00:00:00

  • Expression of protease-activated receptor-1 and -2 in orofacial granulomatosis.

    abstract:OBJECTIVE:Orofacial granulomatosis (OFG) is a rare condition characterized by non-caseating granulomas in the orofacial region. Protease-Activated Receptors (PARs) play a role in inflammatory diseases in diverse human tissues. The aim of the study was to investigate the expression of PAR-1, PAR-2, MMP-2, MMP-9, COX-1, ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/j.1601-0825.2006.01317.x

    authors: Ketabchi S,Massi D,Ficarra G,Rubino I,Franchi A,Paglierani M,Simoni A,Capodiferro S,Favia G,Maiorano E,Tarantini F,Cirino G,Santucci M

    更新日期:2007-07-01 00:00:00

  • The impact of age on oral squamous cell carcinoma: A longitudinal cohort study of 2,782 patients.

    abstract:BACKGROUND:The purposes of this study were to assess the influence of age on oral squamous cell carcinoma patients and sought to analyze the reasons that may contribute to this difference. METHODS:This study enrolled 2,782 patients included 2,443 patients in a retrospective cohort to find the influence of age and 339 ...

    journal_title:Oral diseases

    pub_type: 杂志文章

    doi:10.1111/odi.13015

    authors: Xu Q,Wang C,Li B,Kim K,Li J,Mao M,Qin L,Li H,Huang X,Xing R,Han Z,Feng Z

    更新日期:2019-04-01 00:00:00