Periodontitis in tonsil cancer patients-A comparative study in accordance with tumour p16 status.

Abstract:

OBJECTIVES:We assessed the periodontal situation radiologically according to tumour p16 status. MATERIALS AND METHODS:Patients with a diagnosis of tonsillar cancer and availability of a digital panoramic radiograph (DPR) during a 5-year period were included in this retrospective study. The predictor variables were periodontal stability, marginal bone loss, marginal bone loss without periodontal stability and total number of teeth. Periodontal status was compared with p16 status, age, gender, smoking and alcohol use. RESULTS:Among 115 patients included in the analyses (p16-negative, n = 24; p16-positive, n = 91), smoking (p < .0001), heavy alcohol use (p < .0001) and total number of teeth (p = .0001) were significantly associated with p16 status. Current smoking (OR = 7.3) and heavy alcohol use (OR = 10.1) increased the risk of p16-negative cancer. CONCLUSIONS:Patients with p16-negative tonsillar carcinoma had less teeth than patients with p16-positive tumours. Other periodontal findings were common in both groups without statistical significance. Heavy alcohol use and smoking were the most important risk factors for p16-negative tonsillar carcinoma.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Keinänen A,Marinescu-Gava M,Uittamo J,Hagström J,Marttila E,Snäll J

doi

10.1111/odi.13437

subject

Has Abstract

pub_date

2020-11-01 00:00:00

pages

1625-1630

issue

8

eissn

1354-523X

issn

1601-0825

journal_volume

26

pub_type

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