Abstract:
OBJECTIVE:The aim of this study was to establish a possible association between the degree of differentiation of squamous cell carcinomas (SCC) derived from rat oral tissues treated in vivo with carcinogen 4NQO, and the expression of TGF-beta on epithelial cells and the distribution of extracellular matrix proteins (laminin-collagen type IV). MATERIALS AND METHODS:A parent tumor showing a spectrum of differentiation was used to establish clonal subpopulations that formed differentiated SCC and undifferentiated (spindle cell phenotype) tumours following transplantation to athymic mice. RESULTS:Immunohistological findings revealed the absence of TGF-beta staining on epithelial cells and extracellular matrix proteins in spindle cell tumours. In contrast, staining of SCC revealed a significant number of TGF-beta positive cells and the presence of extracellular matrix proteins. CONCLUSIONS:The findings suggested that there is a positive correlation between histological differentiation, TGF-beta expression and the elaboration of extracellular matrix proteins.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Poulopoulos AK,Kayavis IG,Papanayotou Pdoi
10.1111/j.1601-0825.1996.tb00198.xsubject
Has Abstractpub_date
1996-03-01 00:00:00pages
18-24issue
1eissn
1354-523Xissn
1601-0825journal_volume
2pub_type
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