Role of oral examination in newly diagnosed multiple myeloma patients: A safe and simple way to detect light chain amyloidosis.

Abstract:

OBJECTIVE:Up to 30% of multiple myeloma (MM) patients have subclinical amyloid deposits. These patients are under-recognized and are more susceptible to drug toxicity, bleeding and death. Early diagnosis and adjustment of treatment are crucial. Biopsies of oral mucosa might be a potentially useful diagnostic tool. The objective of this study was to assess the prevalence and characteristics at presentation of oral amyloidosis in a large cohort of MM patients. METHODS:The prevalence and characteristics of oral amyloidosis in a large cohort of MM patients who were referred for oral evaluation before and during bisphosphonate therapy were assessed, retrospectively. RESULTS:Among 212 patients analysed, 13 (6%) were diagnosed with concomitant light chain (AL) amyloidosis. In 54% (n = 7), lesions in the oral cavity compatible with amyloid deposition were detected by examination. CONCLUSIONS:The salient feature of this study is the high prevalence of oral manifestations among MM patients with amyloidosis. These results highlight the value of routine oral cavity examination and biopsy as a safe and simple method for detecting light chain amyloidosis.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Leiba M,Jarjoura S,Abboud W,Nagler A,Yahalom R,Duek A,Yarom N

doi

10.1111/odi.12901

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1343-1348

issue

7

eissn

1354-523X

issn

1601-0825

journal_volume

24

pub_type

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