Abstract:
OBJECTIVE:To compare the diagnostic accuracy of 18 F-FDG PET/CT and conventional contrast-enhanced CT for the re-staging of recurrent salivary gland carcinoma (SGC). MATERIALS AND METHODS:This study included 58 consecutive patients who underwent recurrent SGCs after definitive treatment. The recurrences were evaluated by 18 F-FDG PET/CT and contrast-enhanced CT of the neck and chest. McNemar's test was used to compare the diagnostic accuracy of 18 F-FDG PET/CT with standard neck and chest CT imaging, and a Cox proportional hazards model was used to assess the prognostic value of PET/CT. RESULTS:Of 58 patients with recurrent SGCs, 17 (29%) had a local recurrence, 17 (29%) had a regional recurrence, and 38 (66%) had a distant metastasis, with these classifications showing overlap. The sensitivity and accuracy of 18 F-FDG PET/CT for the detection of distant metastases were significantly higher than those of CT (p < 0.05), whereas, for detection of loco-regional recurrences, they did not differ (p > 0.1). The 18 F-FDG PET/CT-positive findings at distant sites were predictors of poor progression-free and overall survival outcome (all p < 0.05). CONCLUSIONS:18 F-FDG PET/CT is a more effective method than CT for detecting distant site recurrences of SGC. This may lead to prognostic prediction for recurrent SGCs.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Lee SH,Roh JL,Kim JS,Lee JH,Choi SH,Nam SY,Kim SYdoi
10.1111/odi.12877subject
Has Abstractpub_date
2018-09-01 00:00:00pages
940-947issue
6eissn
1354-523Xissn
1601-0825journal_volume
24pub_type
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