Metalloproteinase 9 is the outer executioner of desmoglein 3 in apoptotic keratinocytes.

Abstract:

OBJECTIVE:To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes. METHOD:Inhibitor studies on cultured keratinocytes and Western blot analysis. RESULTS:Blocking of MMP-9 activity strongly reduces shedding of Dsg3 from cell surface. MMP-2 has a less relevant role in the cleavage of Dsg3 while other MMPs, such as MMP-1, -3, and -8, do not target Dsg3. CONCLUSION:Apoptic keratinocytes impair the extracellular domain of cell surface Dsg3 by MMP-9 activity. The discovery of a specific targeting of Dsg3 could be useful to understand the pathophysiology of diseases in which Dsg3 is affected.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Cirillo N,Femiano F,Gombos F,Lanza A

doi

10.1111/j.1601-0825.2006.01287.x

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

341-5

issue

3

eissn

1354-523X

issn

1601-0825

pii

ODI1287

journal_volume

13

pub_type

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