Abstract:
OBJECTIVE:To investigate the specific matrix metalloproteinases (MMPs) targeting desmoglein 3 (Dsg3) in apoptotic keratinocytes. METHOD:Inhibitor studies on cultured keratinocytes and Western blot analysis. RESULTS:Blocking of MMP-9 activity strongly reduces shedding of Dsg3 from cell surface. MMP-2 has a less relevant role in the cleavage of Dsg3 while other MMPs, such as MMP-1, -3, and -8, do not target Dsg3. CONCLUSION:Apoptic keratinocytes impair the extracellular domain of cell surface Dsg3 by MMP-9 activity. The discovery of a specific targeting of Dsg3 could be useful to understand the pathophysiology of diseases in which Dsg3 is affected.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Cirillo N,Femiano F,Gombos F,Lanza Adoi
10.1111/j.1601-0825.2006.01287.xsubject
Has Abstractpub_date
2007-05-01 00:00:00pages
341-5issue
3eissn
1354-523Xissn
1601-0825pii
ODI1287journal_volume
13pub_type
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