Herpesviruses viral loads and levels of proinflammatory cytokines in apical periodontitis.

Abstract:

OBJECTIVES:This study aimed to analyse Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) viral loads in symptomatic and asymptomatic apical periodontitis lesions, to determine levels of TNF-α, IL-1β and IL-6 in these lesions and to investigate a possible correlation between herpesviral copy numbers and levels of proinflammatory cytokines. MATERIALS AND METHODS:A total of 100 samples of apical periodontitis were subjected to HCMV and EBV copy numbers analysis by nested polymerase chain reaction (PCR) and TaqMan real-time PCR. The concentrations of TNF-α, IL-1β and IL-6 were determined by ELISA method. SPSS software was used for statistical analysis. RESULTS:There were no significant differences in the occurrence of EBV and HCMV between symptomatic and asymptomatic periapical lesions (p = .686, p = .879, respectively). Only 12 of 74 EBV (16.2%) and four of 54 HCMV (13.5%) nested PCR-positive samples showed increased viral copy numbers above the limit of 125 copies/ml. There was no significant correlation between the levels of analysed proinflammatory cytokines and herpesviral copy numbers in our sample. CONCLUSION:The observed low viral loads point to a relatively rare occurrence of active EBV and HCMV infection in our sample. Latent herpesviral infection does not enhance the production of investigated proinflammatory cytokines.

journal_name

Oral Dis

journal_title

Oral diseases

authors

Jakovljevic A,Knezevic A,Nikolic N,Soldatovic I,Jovanovic T,Milasin J,Andric M

doi

10.1111/odi.12829

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

840-846

issue

5

eissn

1354-523X

issn

1601-0825

journal_volume

24

pub_type

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