Abstract:
:Orofacial granulomatosis (OFG) is the presence of persistent enlargement of the soft tissues of the oral and maxillofacial region, characterized by non-caseating granulomatous inflammation in the absence of diagnosable systemic Crohn's disease (CD) or sarcoidosis. Over 20 years have passed since OFG was first described and an extensive review of the literature reveals that there is no consensus whether OFG is a distinct clinical disorder or an initial presentation of CD or sarcoidosis. Furthermore, the precise cause of OFG is still unknown although several theories have been suggested including infection, genetic predisposition and allergy. The clinical outcome of OFG patients continues to be unpredictable. Current therapies remain unsatisfactory. Regular clinical review is indicated to identify the development of gastrointestinal or systemic involvement. The aim of this review was to analyse the developments in our understanding of the aetiology, pathogenesis and treatment protocols, with particular emphasis on management and outcomes of OFG since this entity was first described in 1985.
journal_name
Oral Disjournal_title
Oral diseasesauthors
Grave B,McCullough M,Wiesenfeld Ddoi
10.1111/j.1601-0825.2008.01500.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
46-51issue
1eissn
1354-523Xissn
1601-0825pii
ODI1500journal_volume
15pub_type
杂志文章,评审相关文献
ORAL DISEASES文献大全abstract:OBJECTIVE:We investigated the relationship amongst the oral mucosal bacterial community, clinical severity and inflammatory markers in the two most common immune-mediated oral mucosal diseases, namely recurrent aphthous stomatitis (RAS) and oral lichen planus (LP). METHODS:Patients with RAS (n = 15) and LP (n = 18) an...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13420
更新日期:2020-10-01 00:00:00
abstract::With a history of over 2000 years, traditional Chinese medicine (TCM) evolves into a unique system of diagnosing and treating illnesses. It is a challenge to convey the fundamentals of this traditional medicine to our Western colleagues because of the differences in language, philosophy and concept of diagnosis and tr...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/j.1601-0825.2010.01706.x
更新日期:2011-01-01 00:00:00
abstract::As the AIDS pandemic has continued, our understanding of the events that occur during the entry and infection of conventional, susceptible cells has increased dramatically, leading to the development of control therapies for HIV-infected individuals. However, an ongoing hole in our understanding is how HIV crosses the...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12410
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to determine whether the expression levels of specific circulating serum microRNAs (miRNAs) are associated with mandibular prognathism (MP). METHODS:Sixty subjects in the early permanent dentition stage and 23 in the mixed dentition stage with MP were identified. Sixty-eight normal ...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12073
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVES:To investigate tooth ultrastructure and mutation of two patients in a family affected with osteogenesis imperfecta (OI) type IV and dentinogenesis imperfecta (DGI). METHODS:Mutations were detected by whole exome and Sanger sequencing. The permanent second molar obtained from the proband (DGI1) and the prima...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13657
更新日期:2020-09-29 00:00:00
abstract::The human microbiome consists of all microorganisms occupying the skin, mucous membranes and intestinal tract of the human body. The contact of the mucosal immune system with the human microbiome is a balanced interplay between defence mechanisms of the immune system and symbiotic or pathogenic microbial factors, such...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12472
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVES:To investigate practices and opinions of general dentists in Maryland, USA, related to oral and pharyngeal cancer prevention and early detection. DESIGN AND METHODS:A pre-tested, 34-item questionnaire, cover letter and addressed, stamped envelope were mailed in the summer, 1995, to a simple random sample of...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2000.tb00140.x
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:To investigate a possible role of adiponectin in the pathogenesis of autoimmune sialoadenitis in non-obese diabetic (NOD) mouse model of Sjögren's syndrome. MATERIALS AND METHODS:Expression of adiponectin and its receptors (AdipoR1/2) was detected by PCR, immunoblotting, or immunofluorescence. The level of a...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12197
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:Neutrophils play a crucial role in the defense of invading bacteria by releasing biologically active molecules. The response of peripheral blood neutrophils was studied in periodontitis-affected patients and in healthy controls towards stimulation to Porphyromonas gingivalis (Pg) and Actinobacillus actinomyce...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01323.x
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Tobacco-related oral squamous cell carcinoma (OSCC) is one of the most common cancers involving Indian males. We assessed the association of IL4 promoter -589 T>C, -33 T>C, and IL6-174 G>C functional genetic polymorphisms with tobacco-related OSCC in Asian Indians. PATIENTS AND METHODS:The IL4 and IL6 promo...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2011.01831.x
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Homeobox are a family of developmental genes involved in morphogenesis and cellular differentiation. Participation of homeobox within normal and malignant tissue has been recently discussed in the literature. OBJECTIVE:To analyze the presence of HOXB13 transcript expression in human minor salivary gland. M...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01218.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To determine the effect of smoking on peptidoglycan recognition protein (PGRP)-1 levels in gingival crevicular fluid (GCF) in smokers and non-smokers with chronic periodontitis (CP) following initial periodontal therapy. SUBJECTS AND METHODS:A total of 40 patients with CP (20 smokers (S + CP) and 20 non-smok...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13207
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:To determine the impact of highly active antiretroviral therapy (HAART) on salivary gland function in human immunodeficiency virus (HIV) positive women from the Women's Interagency HIV Study (WIHS). DESIGN:Longitudinal cohort study. SUBJECTS AND METHODS:A total of 668 HIV positive women from the WIHS cohort...
journal_title:Oral diseases
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1601-0825.2008.01456.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the genetic instability of peripheral blood lymphocytes from patients diagnosed with oral lichen planus (OLP) by investigation of frequencies of micronuclei (MN) and sister chromatid exchange (SCE). MATERIALS AND METHODS:A total of 22 newly diagnosed and untreated p...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01576.x
更新日期:2009-10-01 00:00:00
abstract::Oral potentially malignant disorders (OPMDs) are associated with an increased risk of occurrence of cancers of the lip or oral cavity. This paper presents an updated report on the nomenclature and the classification of OPMDs, based predominantly on their clinical features, following discussions by an expert group at a...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.13704
更新日期:2020-10-31 00:00:00
abstract:OBJECTIVES:siRNA-induced gene silencing in the salivary gland using microbubble-enhanced sonoporation was used to develop an in vivo gene knockdown technique. METHODS:siRNA targeting rat glyceraldehyde-3-phosphate dehydrogenas (GAPDH) was mixed with echo-enhanced microbubbles and reverse-injected into rat parotid glan...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2009.01579.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the prevalence of areca nut consumption and to identify social and behavioural determinants among a Taiwanese adolescent population. SUBJECTS AND METHODS:A random sample of 5,343 high school students aged between 15-18 years in Kaohsiung, Taiwan, participated in the study. Par...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.13467
更新日期:2020-11-01 00:00:00
abstract::Dental teams have been involved with child protection for over 40 years. This brief review summarises their involvement in the detection of various types of child abuse and goes on to discuss the gap between the proportions of dental professionals who suspect child abuse or neglect in their paediatric patients and tho...
journal_title:Oral diseases
pub_type: 历史文章,杂志文章,评审
doi:10.1111/odi.12485
更新日期:2016-10-01 00:00:00
abstract::Osteonecrosis of the jaw may be caused by radiation, medication, or infection. Optimal therapy requires a multimodal approach that combines surgery with adjuvant treatments. This review focuses on the use of adjunctive hyperbaric oxygen therapy for this condition. In addition to evidence regarding the basic and clinic...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12489
更新日期:2017-03-01 00:00:00
abstract::Most viral infections encountered in resource-rich countries are relatively trivial and transient with perhaps fever, malaise, myalgia, rash (exanthema) and sometimes mucosal manifestations (enanthema), including oral in some. However, the apparent benignity may be illusory as some viral infections have unexpected con...
journal_title:Oral diseases
pub_type: 杂志文章,评审
doi:10.1111/odi.12356
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:To explore the potential of detecting the level of proinflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), interleukin-1-alpha (IL-1-alpha), IL-6, and IL-8 in whole unstimulated saliva (WUS) in monitoring the therapeutic effects of topical dexamethasone on these salivary cytokines in subjects with...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2005.01165.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To investigate the clinicopathological characteristics and biologic behaviour of epithelioid hemangioendothelioma in the oral cavity. MATERIALS AND METHODS:The clinical features and pathological findings of nine cases with intraoral epithelioid hemangioendothelioma were reviewed, including immunohistochemist...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01281.x
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:Autoimmune mechanisms may contribute to periodontal disease (PD) pathogenesis; autoantibody to collagen type 1 is produced at the periodontal site and local levels are found to be higher than in serum. OBJECTIVES:To find any evidence of autoimmune destruction in diseased periodontal tissues in patients with...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1046/j.1354-523x.2003.00961.x
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:There is little knowledge about the tooth replacement in large mammals. The aim of this study is to investigate the tooth replacement patterns in Chinese miniature pig (Sus Scrofa). MATERIALS AND METHODS:The developmental patterns of mandibular successional and additional teeth from Chinese miniature pig bef...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12126
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To investigate the association of miR-499a genetic polymorphism with the risk of oral leukoplakia, oral submucous fibrosis (OSF), oral squamous cell carcinoma (OSCC), and clinicopathological outcomes of OSCC. METHODS:The genotyping of miR-499a T>C (rs3746444) using TagMan assay was conducted in two case-cont...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12241
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare viscosity and wettability between animal mucin solutions and human saliva. MATERIALS AND METHODS:Human whole and glandular saliva, porcine gastric mucin, bovine submaxillary mucin, and a mucin-based saliva substitute were used. Viscosity was measured with a cone-and-p...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2006.01263.x
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:The expression of the inducible nitric oxide synthase enzyme (iNOS) is a response to an inflammatory stimulus and produces a large amount of nitric oxide (NO), which may act as a cytotoxic molecule against the invading microorganism and may be related to both harmful and beneficial effects to tissues. OBJEC...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1034/j.1601-0825.2002.02852.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:Oral lichen planus is a chronic inflammatory oral mucosal disease whose exact cause is unclear and which requires efficient diagnostic and therapeutic strategies. Identification of disease-specific biomarkers in saliva is an easy, quick, and non-invasive approach for molecular diagnosis. This study was design...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/odi.12374
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVES:A multicentre collaborative study by the London HIV and Dentistry Group failed to associate the presence of erythematous candidiasis (EC) with advanced HIV disease. Data from a study of the periodontal health of homosexual men attending a genito-urinary medicine clinic presented an opportunity to investigate...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.1997.tb00339.x
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVES:To determine the extent to which clinical and radiographic features of bisphosphonate-associated osteonecrosis of the jaw (BONJ) are correlated. DESIGN:Retrospective case review. METHODS:The records of 39 patients diagnosed with BONJ and examined by panoramic radiography were retrospectively evaluated. The...
journal_title:Oral diseases
pub_type: 杂志文章
doi:10.1111/j.1601-0825.2008.01494.x
更新日期:2009-01-01 00:00:00