Abstract:
:The labelling of gangliosides and sialoglycoproteins (SGP) after injecting intraocularly 30 ?Ci of [(3)H]ManNAc was studied in chickens that had previously received, also intraocularly, 30 or 70 nmol of monensin in 10 ?l of ethanol or 24 ?g of colchicine in 10 ?l saline. Controls received ethanol or saline only. Colchicine at doses that almost completely block the axonal transport to the optic tectum does not affect the labelling of those sialocompounds. The translocation of gangliosides and SGP, measured as a percentage of accessibility to the sialidase was inhibited by colchicine, but this effect was different for gangliosides and for SGP. In contrast, monensin, also at doses that block axonal transport, inhibits the synthesis and the translocation of gangliosides and SGP. It also modifies the labelling pattern of retinal gangliosides, which with respect to the normal pattern shows an increase in the relative labelling of GM(3), GD(3), GM(1) and probably GD(1b) and a decrease in GD(1a) and GT(1b). The activity of UDP-GalNAc: GM(3), GalNAc transferase (EC 2.4.1.79) of retina membranes of chickens that received an intraocular injection of monensin 4 h before being sacrificed showed a dose-dependent decrease with respect to the controls. In experiments in vitro monensin at a concentration of 3 mM failed to inhibit this activity.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Nores GA,Caputto Rdoi
10.1016/0197-0186(86)90183-xsubject
Has Abstractpub_date
1986-01-01 00:00:00pages
501-6issue
4eissn
0197-0186issn
1872-9754pii
0197-0186(86)90183-Xjournal_volume
8pub_type
杂志文章abstract::NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable better control of ...
journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2012.02.007
更新日期:2012-04-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/j.neuint.2009.01.025
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abstract::TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...
journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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pub_type: 杂志文章,评审
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/s0197-0186(00)00034-6
更新日期:2001-02-01 00:00:00
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2010.10.007
更新日期:2011-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/j.neuint.2013.11.003
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journal_title:Neurochemistry international
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journal_title:Neurochemistry international
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doi:10.1016/j.neuint.2003.07.001
更新日期:2004-05-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/s0197-0186(97)00126-5
更新日期:1998-05-01 00:00:00
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journal_title:Neurochemistry international
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doi:10.1016/j.neuint.2012.11.007
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journal_title:Neurochemistry international
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更新日期:2018-03-01 00:00:00
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doi:10.1016/j.neuint.2019.104495
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(87)90055-6
更新日期:1987-01-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章,评审
doi:10.1016/0197-0186(93)90016-x
更新日期:1993-04-01 00:00:00
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journal_title:Neurochemistry international
pub_type: 杂志文章
doi:10.1016/0197-0186(85)90035-x
更新日期:1985-01-01 00:00:00