Activated microglia are the principal glial source of thromboxane in the central nervous system.

abstract：:Metabotropic glutamate receptors (mGluRs) are expressed in neural progenitor cells (NPCs) and may play important roles in the neurogenesis during embryonic development and adult brain repair following injuries. In the present study, we investigated the expression of metabotropic glutamate receptor 7 (mGluR7) and the p...

journal_title：Neurochemistry international

authors： Tian Y,Liu Y,Chen X,Kang Q,Zhang J,Shi Q,Zhang H

更新日期：2010-08-01 00:00:00

abstract：:Protein kinase C (PKC) is involved in several cell events including proliferation, survival and differentiation. The aim of this work was to investigate the role of PKC activation on retinal cells proliferation. We demonstrated that PKC activation by phorbol 12-myristate 13-acetate (PMA), a tumor promoter phorbol este...

journal_title：Neurochemistry international

authors： dos Santos AA,Medina SV,Sholl-Franco A,de Araujo EG

更新日期：2003-01-01 00:00:00

abstract：:The synthesis of neurotransmitter glutamate in brain is mainly carried out by glutaminase enzymes. This synthesis must be exquisitely regulated because of its harmful potential giving rise to excitotoxic damage. It is noteworthy that two glutaminase isozymes coded by different genes are expressed in the brain of mamma...

journal_title：Neurochemistry international

authors： de la Rosa V,Campos-Sandoval JA,Martín-Rufián M,Cardona C,Matés JM,Segura JA,Alonso FJ,Márquez J

更新日期：2009-07-01 00:00:00

abstract：:Evidences have indicated a high degree of comorbidity of alcoholism and depression. N-acetylcysteine (NAC) has shown its clinical efficiency in the treatment of several psychiatric disorders and is identified as a multi-target acting drug. The ability of NAC to prevent alcohol abstinence-induced depression-like effect...

journal_title：Neurochemistry international

authors： Yawalkar R,Changotra H,Gupta GL

更新日期：2018-09-01 00:00:00

abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

journal_title：Neurochemistry international

authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

更新日期：2006-12-01 00:00:00

abstract：:Nucleotides can be released as signaling substances in the nervous system from both neural and glial cells. Their function is terminated by ecto-nucleotidases and sequential extracellular metabolism to the nucleoside. Recently considerable progress has been made in unraveling the molecular structure of an ecto-ATPase ...

journal_title：Neurochemistry international

authors： Zimmermann H,Braun N,Kegel B,Heine P

更新日期：1998-05-01 00:00:00

abstract：:In the last few years, several attempts were made for the setting up of specific methodologies aiming to evaluate steroid contents directly in nervous tissues. The main objective of these attempts was to determine accurately changes intervening in endogenous neuroactive steroid levels during pathological situations. T...

journal_title：Neurochemistry international

authors： Melcangi RC,Mensah-Nyagan AG

更新日期：2008-03-01 00:00:00

abstract：:Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

journal_title：Neurochemistry international

authors： Voronkov M,Cocchiaro B,Stock JB

更新日期：2020-12-10 00:00:00

abstract：:Changes in the level of ornithine decarboxylase mRNA after partial mesodiencephalic hemitransection were evaluated in various regions of the rat brain by means of in situ hybridization histochemistry coupled with computer-assisted image analysis. On days 1 and 2 after the lesion, increased accumulation of ornithine de...

journal_title：Neurochemistry international

authors： Zoli M,Bettuzzi S,Ferraguti F,Ingletti MC,Zini I,Fuxe K,Agnati LF,Corti A

更新日期：1991-01-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

journal_title：Neurochemistry international

authors： Jiang H,Song N,Wang J,Ren LY,Xie JX

更新日期：2007-07-01 00:00:00

abstract：:There has arisen considerable interest in the study of dopamine D(2/3) agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional antagonist ligands. To test the basis of this claim, we used ...

journal_title：Neurochemistry international

authors： Minuzzi L,Cumming P

更新日期：2010-05-01 00:00:00

abstract：:The observation that autophosphorylation converts CaM kinase II from the Ca(2+)-dependent form to the Ca(2+)-independent form has led to speculation that the formation of the Ca(2+)-independent form of the enzyme could encode frequency of synaptic usage and serve as a molecular explanation of "memory". In cultured rat...

journal_title：Neurochemistry international

authors： Fukunaga K,Muller D,Miyamoto E

更新日期：1996-04-01 00:00:00

abstract：:Although the cerebral cortical dopamine D(1) receptor is considered to play a role in normal and abnormal brain function, little information is available on its characteristics in human brain. We compared dopamine-stimulated adenylyl cyclase (AC) activity in homogenates of cerebral cortex (frontal, temporal, parietal,...

journal_title：Neurochemistry international

authors： Tong J,Ross BM,Sherwin AL,Kish SJ

更新日期：2001-08-01 00:00:00

abstract：:Insulin receptors from rat brain regions were studied for insulin binding and receptor associated kinase activity, in alloxan induced short-term and long-term diabetes, and insulin induced hypoglycemia. Insulin receptor activity was assessed by [125I]insulin binding, and basal as well as insulin stimulated kinase acti...

journal_title：Neurochemistry international

authors： Gupta G,Azam M,Baquer NZ

更新日期：1992-06-01 00:00:00

abstract：:In the present study we investigated the effects of a single injection of reserpine on dopamine receptor function in rat striatum. The measurement of adenylate cyclase activity indicated that cAMP formation induced by the selective D-1 agonist SKF 82526 was greatly increased 2 and 20 h after reserpine; in contrast, th...

journal_title：Neurochemistry international

authors： Liberini P,Nisoli E,Missale C,Memo M,Buonamici M,Rossi A,Spano PF

更新日期：1989-01-01 00:00:00

abstract：:Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

journal_title：Neurochemistry international

authors： Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

更新日期：2020-10-01 00:00:00

abstract：:The effect of GM(1) administration upon the time course of the postlesion changes of [(3)H]5hydroxytryptamine uptake in the partially denervated rat hippocampus has been studied 6, 21, 42 and 90 days after surgery. At 6 and 21 days after operation the postlesion decrease of [(3)H]5-hydroxytryptamine uptake was counter...

journal_title：Neurochemistry international

authors： Kiedrowski L,Gra Dkowska M,Oderfeld-Nowak B

更新日期：1987-01-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is linked to several neurological disorders, and neuronal injury cascades initiated by excessive ER stress are mediated, in part, via mitochondrial dysfunction. In the present study, we identified FAM3A as an important regulator of ER stress-induced cell death in neuronal HT22 cells. ...

journal_title：Neurochemistry international

authors： Song Q,Gou WL,Zhang R

更新日期：2016-03-01 00:00:00

abstract：:Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifest...

journal_title：Neurochemistry international

authors： Byrnes J,Ganetzky R,Lightfoot R,Tzeng M,Nakamaru-Ogiso E,Seiler C,Falk MJ

更新日期：2018-07-01 00:00:00

abstract：:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of cal...

journal_title：Neurochemistry international

authors： Casteels R,Droogmans G,Missiaen L

更新日期：1990-01-01 00:00:00

abstract：:Two puromycin-sensitive aminopeptidase isozymes (PSA-I and PSA-II) were isolated from chicken brain cytosol by ammonium sulfate fractionation followed by column chromatography on Cellex D and AH-Sepharose 4B and separated on Bio-Gel HTP. Each was purified to homogeneity on Sephadex G-200, Arg-Tyr-AH-Sepharose, Bio-Gel...

journal_title：Neurochemistry international

authors： Hui KS,Saito M,Hui M,Saito M,Lajtha A,Yamamoto K,Osawa T

更新日期：1993-05-01 00:00:00

abstract：:The rat retinal ganglion cell (RGC) line RGC-5 constitutes a widely used model for studying physiological processes in retinal cells. In this paper we investigated the expression of clock and immediately early genes, and calcium mediated responses to physiological stimuli in differentiated and mitotically active RGC-5...

journal_title：Neurochemistry international

authors： Nieto PS,Acosta-Rodríguez VA,Valdez DJ,Guido ME

更新日期：2010-10-01 00:00:00

abstract：:Dipyridamole (DPR) and nitrobenzylthioinosine (NBI) inhibition of adenosine accumulation in synaptoneurosomes derived from rat cerebral cortex, rat cerebellum, guinea pig cerebral cortex and guinea pig cerebellum was investigated. The inhibition of adenosine accumulation by NBI was observed to be distinctly biphasic i...

journal_title：Neurochemistry international

authors： Morgan PF,Marangos PJ

更新日期：1987-01-01 00:00:00

abstract：:DJ-1 (also known as PARK7) is a redox-active protein that protects against oxidative stress. This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure a...

journal_title：Neurochemistry international

authors： Tsai CY,Wu CJ,Wu JCC,Fang C,Huang YH,Dai KY

更新日期：2020-10-01 00:00:00

abstract：:Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

journal_title：Neurochemistry international

authors： Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

更新日期：2003-06-01 00:00:00

abstract：:Alteration in the lysosomal system (LS) may represent a central mechanism in neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death in catecholaminergic cells. The LS and caspases participate in apoptosis, although the mechanism(s) that is involved is not completely understood. Here, we ...

journal_title：Neurochemistry international

authors： Lee DC,Womble TA,Mason CW,Jackson IM,Lamango NS,Severs WB,Palm DE

更新日期：2007-03-01 00:00:00

abstract：:The results of the present study showed the presence of a high-affinity and saturable binding of [3H]-ketanserin to frontal and parietal brain membranes obtained postmortem from bipolar, depressed, schizophrenic patients and normal controls. The human brain samples (60 frontal cortex and 51 parietal cortex), were dona...

journal_title：Neurochemistry international

authors： Marazziti D,Giannaccini G,Giromella A,Betti L,Pesce D,Nardi I,Rossi A,Lucacchini A,Cassano GB

更新日期：2003-05-01 00:00:00

abstract：:The sensitivity of [(3)H]GABA and [(3)H]muscimol high-affinity binding sites to physiological (Krebs-Ringer's bicarbonate) and non-physiological (Tris-citrate) buffers was examined using synaptosomal membranes from bovine retinas. The maximum number of sites (B(max)) for [(3)H]GABA was present when the tissue was assa...

journal_title：Neurochemistry international

authors： Madtes P Jr,Bashir-Elahi R,Chader GJ

更新日期：1986-01-01 00:00:00

abstract：:There were specific changes in the contents of cytoskeletal components and their organization during glioblast differentiation induced by glia maturation factor (GMF). Vimentin and glial fibrillary acidic protein increased in their contents, whereas actin did not. Tubulin was only a minor component of the glial cytosk...

journal_title：Neurochemistry international

authors： Suzuki T,Kato T,Fujii T,Tanaka R

更新日期：1986-01-01 00:00:00

abstract：:Thyrotropin releasing hormone (TRH) present in several brain areas has been proposed as a neuromodulator. Its administration produces opposite effects to those observed with acute ethanol consumption. Opioid peptides, in contrast, have been proposed to mediate some of the effects of alcohol intoxication. We measured T...

journal_title：Neurochemistry international

authors： de Gortari P,Méndez M,Rodríguez-Keller I,Pérez-Martínez L,Joseph-Bravob P

更新日期：2000-11-01 00:00:00