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Agonist-induced entry of Ca(2+) in smooth muscle cells.

Abstract：

:The changes in intracellar Ca(2+)-concentration, which occur during stimulation of vascular smooth muscle cells with excitatory agonists, are discussed. The effects of these agonists on the membrane potential of these cells are indirect, and mainly due to an activation of K(+)- and Cl(?)-channels by the release of calcium from internal stores. Voltage-dependent Ca(2+)-channels are only activated if the cells depolarize beyond the threshold for activation of these channels. However, the influx of calcium through these channels is strongly inhibited by the agonists, probably via activation of protein kinase C. The mechanism of agonist-mediated Ca(2+)-entry is shown to be modulated by the degree of Ca(2+)-depletion of the agonist-sensitive Ca(2+)-stores. Arguments are presented in favour of a direct pathway for Ca(2+)-entry from the extracellular medium into this agonist-sensitive store.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Casteels R,Droogmans G,Missiaen L

doi

10.1016/0197-0186(90)90152-j

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

297-302

issue

2

eissn

0197-0186

issn

1872-9754

pii

0197-0186(90)90152-J

journal_volume

17

pub_type

杂志文章

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