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Presenilin-1 and the amyloid precursor protein are transported bidirectionally in the sciatic nerve of adult rat.

Abstract：

:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport of these proteins has been demonstrated in the sciatic nerve of adult rat. Double-ligation of the sciatic nerve for 6, 12 or 24h was observed to cause a progressive accumulation of the 45kDa presenilin-1 holoprotein and APPs with molecular masses of 116 and 94kDa on both sites of the ligature. It is concluded that the functions of presenilin-1 and APPs are not restricted to the neuronal perikarya: they may carry information in both directions, from the cell body to the axon terminals and vice versa.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Papp H,Pakaski M,Kasa P

doi

10.1016/s0197-0186(02)00014-1

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

429-35

issue

6

eissn

0197-0186

issn

1872-9754

pii

S0197018602000141

journal_volume

41

pub_type

杂志文章

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