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Inhibition of chick brain cholesterogenic enzymes by phenyl and phenolic derivatives of phenylalanine.

Abstract：

:Phenylalanine and its phenyl metabolites produced a clear inhibition of chick brain mevalonate 5-pyrophosphate decarboxylase, while mevalonate kinase and mevalonate 5-phosphate kinase were not significantly affected. Phenolic derivatives produced a similar or higher inhibition than that found in the presence of phenyl metabolites. The inhibition was progressive with increasing concentrations of inhibitors (1.25-5.00 mM). Phenylpyruvate and p-hydroxyphenyl-lactate were the most potent inhibitors of decarboxylase activity. Simultaneous supplementation of each metabolite at 0.25 mM concentration produced a considerable inhibition of brain decarboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase. At our knowledge this is the first report on the in vitro inhibition of both brain regulatory enzymes of cholesterogenesis in phenylketonuric-like conditions.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Castillo M,Iglesias J,Zafra MF,Garcia-Peregrin E

doi

10.1016/0197-0186(91)90182-d

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

171-4

issue

2

eissn

0197-0186

issn

1872-9754

pii

0197-0186(91)90182-D

journal_volume

18

pub_type

杂志文章

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