Axonal transports of tripeptidyl peptidase II in rat sciatic nerves.

abstract：BACKGROUND:Axonal injury is the correlate of disease progression in NMO and MS. Neurofilament (Nf) belongs to neuron specific intermediate filaments located in axons. Nf protein subunits are potential biomarkers in cerebrospinal fluid (CSF) for acute axonal injury. However, whether CSF NfH and NfL levels are elevated i...

journal_title：Neurochemistry international

authors： Wang H,Wang C,Qiu W,Lu Z,Hu X,Wang K

更新日期：2013-12-01 00:00:00

abstract：:Neutrophil granulocytes (or polymorphonuclear cells, PMNs) have long been considered as crude killing machines, particularly trained to attack bacterial or fungal pathogens in wounds or infected tissues. That perspective has fundamentally changed over the last decades, as PMNs have been shown to exert a livery exchang...

journal_title：Neurochemistry international

authors： Strecker JK,Schmidt A,Schäbitz WR,Minnerup J

更新日期：2017-07-01 00:00:00

abstract：:Intense glucose-based energy metabolism and glutamate synthesis by astrocytes require malate-aspartate-shuttle (MAS) activity to regenerate NAD⁺ from NADH formed during glycolysis, since brain lacks significant glycerophosphate shuttle activity. Aralar is a necessary aspartate/glutamate exchanger for MAS function in b...

journal_title：Neurochemistry international

authors： Li B,Hertz L,Peng L

更新日期：2012-12-01 00:00:00

abstract：:Microglia, the primary resident immune cells of the central nervous system (CNS), responds rapidly to pathogens and injury by secreting immune mediators including nitric oxide (NO). The reaction of NO with the anti-oxidant glutathione forms S-nitrosoglutathione (GSNO), the major pool of biologic NO in the body. GSNO i...

journal_title：Neurochemistry international

authors： Rossi-George A,Guo CJ

更新日期：2016-10-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00

abstract：:The roles of cyclic AMP and calcium in the regulation of serotonin N-acetyltransferase (NAT) activity were studied in low density monolayer cultures of chick retinal photoreceptors and neurons. Photoreceptor-enriched retinal cell cultures were prepared from embryonic day 6 retinas and cultured for 6 days. NAT activity...

journal_title：Neurochemistry international

authors： Gan J,Alonso-Gómez AL,Avendano G,Johnson B,Iuvone PM

更新日期：1995-08-01 00:00:00

abstract：:Primary cortical neurons exposed to the mitochondrial toxin NaN3 (0.1-3 mM) were submitted to oxidative stress with H2O2 (30-150 μM), to mimic conditions observed in neurodegenerative disorders. The effects of such treatment on a series of parameters useful in characterizing neuronal damage were investigated: (i) the ...

journal_title：Neurochemistry international

authors： Selvatici R,Marani L,Marino S,Siniscalchi A

更新日期：2013-08-01 00:00:00

abstract：:Acetylcholine enhanced in a concentration-dependent way the K(+) (15 mM)-evoked release of [(3)H]dopamine from synaptosomes isolated from rat corpus striatum and prelabeled with the radioactive catecholamine. The concentration-effect curve of ACh obtained in presence of 1.2 mM Ca(2+) was progressively shifted to the l...

journal_title：Neurochemistry international

authors： Versace P,Bocchieri P,Marchi M,Raiteri M

更新日期：1987-01-01 00:00:00

abstract：:To characterise ketamine-induced sympathomimetic action, we examined the effects of ketamine on in vivo cardiac sympathetic nerve endings function. Using adult cats given anaesthesia with pentobarbital, dialysis probes were implanted in the left ventricular myocardium and dialysate noradrenaline (NA) concentrations we...

journal_title：Neurochemistry international

authors： Kitagawa H,Yamazaki T,Akiyama T,Mori H,Sunagawa K

更新日期：2003-02-01 00:00:00

abstract：:Radial glial cells play a significant role in the repair of spinal cord injuries as they exert critical role in the neurogenesis and act as a scaffold for neuronal migration. Our previous study showed that mature astrocytes of spinal cord can undergo a de-differentiation process and further transform into pluripotenti...

journal_title：Neurochemistry international

authors： Yang H,Ling W,Vitale A,Olivera C,Min Y,You S

更新日期：2011-12-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:Resistance to inhibitors of cholinesterase (RIC) -3 promotes the maturation (folding and assembly) of neuronal nicotinic acetylcholine receptors (nAChRs) as a molecular chaperone. The modulation effects of RIC-3 on homomeric α7 nAChRs are always positive, but its effects on heteromeric subtypes are inconsistent among ...

journal_title：Neurochemistry international

authors： Bao H,Xu X,Liu W,Yu N,Liu Z

更新日期：2018-05-01 00:00:00

abstract：:The phenylglycines 3-hydroxyphenylglycine, 4-carboxy-3-hydroxy-phenylglycine (4C3HPG), 4-carboxyphenylglycine (4CPG) and alpha-methyl-4-carboxyphenylglycine (MCPG) were evaluated as putative selective antagonists of metabotropic glutamate receptors on single neurones of the ventrobasal thalamus of rats, with a view to...

journal_title：Neurochemistry international

authors： Salt TE,Eaton SA

更新日期：1994-05-01 00:00:00

abstract：:Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we inves...

journal_title：Neurochemistry international

authors： Rodrigues L,Wartchow KM,Suardi LZ,Federhen BC,Selistre NG,Gonçalves CA

更新日期：2019-09-01 00:00:00

abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

journal_title：Neurochemistry international

authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

更新日期：1982-01-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:Viral infections are implicated in the onset and promotion of autoimmunity in genetically predisposed individuals. In this study, immune response patterns to herpes viruses were compared in aquaporin 4 (AQP4) antibody positive central nervous system (CNS) autoimmunity and multiple sclerosis (MS). Serum samples of pati...

journal_title：Neurochemistry international

authors： Sellner J,Cepok S,Kalluri SR,Nestler A,Kleiter I,Kümpfel T,Linker R,Melms A,Menge T,Tumani H,Paul F,Hemmer B,Berthele A

更新日期：2010-11-01 00:00:00

abstract：:It is well established that histaminergic neurons in the posterior hypothalamus make connections with whole brain areas and regulate several functions. Recent evidence indicates that histaminergic neurons are heterogeneous cell group and organized into distinct circuits. However, functional circuits of histaminergic n...

journal_title：Neurochemistry international

authors： Umehara H,Mizuguchi H,Fukui H

更新日期：2012-11-01 00:00:00

abstract：:It has been reported that mutations of gammaPKC cause hereditary spinocerebellar atrophy type 14 (SCA14). Our recent study has revealed that the SCA14 mutant gammaPKC is susceptible to aggregation and causes cell death. Among mutations/polymorphisms of gammaPKC, the R659S mutation was firstly segregated from families ...

journal_title：Neurochemistry international

authors： Mochizuki H,Seki T,Adachi N,Saito N,Mishima HK,Sakai N

更新日期：2006-12-01 00:00:00

abstract：:Potassium bisperoxo(1,10-phenantroline)oxovanadate (V) [bpV(phen)] is a potent protein tyrocine phosphatase inhibitor which mediates a variety of biological effects. The aim of these studies was to examine the role(s) of mitogen activated protein kinase (MAPK) pathways in PC12 cell proliferation and toxicity by bpV(ph...

journal_title：Neurochemistry international

authors： Cerovac Z,Ban J,Morinville A,Yaccato K,Shaver A,Maysinger D

更新日期：1999-04-01 00:00:00

abstract：:Pregabalin is effective in treating many neuropathic pain conditions. However, the mechanisms of its analgesic effects remain poorly understood. The aim of the present study was to determine whether pregabalin suppresses facial mechanical hypersensitivity and evoked glutamate release in the medullary dorsal horn (MDH)...

journal_title：Neurochemistry international

authors： Kumar N,Cherkas PS,Varathan V,Miyamoto M,Chiang CY,Dostrovsky JO,Sessle BJ,Coderre TJ

更新日期：2013-05-01 00:00:00

abstract：:Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

journal_title：Neurochemistry international

authors： Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

更新日期：1995-03-01 00:00:00

abstract：:JM-20 (3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine) is a novel benzodiazepine dihydropyridine hybrid molecule, which has been shown to be a neuroprotective agent in brain disorders involving glutamate receptors. However, the effect of JM-20 on the functionality of the g...

journal_title：Neurochemistry international

authors： Nuñez-Figueredo Y,Pardo Andreu GL,Oliveira Loureiro S,Ganzella M,Ramírez-Sánchez J,Ochoa-Rodríguez E,Verdecia-Reyes Y,Delgado-Hernández R,Souza DO

更新日期：2015-02-01 00:00:00

abstract：:Guanylate cyclase in the membrane fraction of rod outer segments (ROS-membrane) from the frog retina showed an extremely high activity but had no responsiveness to NaN(3) (+catalase), nitrosoguanidine or superoxide dismutase. These compounds, however, markedly activated the enzyme in a soluble fraction from the retina...

journal_title：Neurochemistry international

authors： Yoshikawa K,Nishimura C,Kuriyama K

更新日期：1982-01-01 00:00:00

abstract：:The parenchyma of the anterior pituitary gland is constituted of distinct specialized glandular cell types, some of them being able to secrete two, or more, genetically related hormones. The synthesis and the release of each hormone is a discontinuous process controlled by a variety of chemical signals of hypothalamic...

journal_title：Neurochemistry international

authors： Gourdji D

更新日期：1985-01-01 00:00:00

abstract：:Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

journal_title：Neurochemistry international

authors： Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

更新日期：2020-10-01 00:00:00

abstract：:The accumulation of extracellular amyloid beta (Abeta42) both in brain and in cerebral vessels characterizes Alzheimer's disease (AD) pathogenesis. Recently, the possibility to functionalize nanoparticles (NPs) surface with Abeta42 binding molecules, making them suitable tools for reducing Abeta42 burden has been show...

journal_title：Neurochemistry international

authors： Conti E,Gregori M,Radice I,Da Re F,Grana D,Re F,Salvati E,Masserini M,Ferrarese C,Zoia CP,Tremolizzo L

更新日期：2017-09-01 00:00:00

abstract：:Many peripheral substances, including ghrelin, induce neuronal activation in the brain. In the present study, we compared the effect of subcutaneously administered ghrelin and its three stable agonists: Dpr(3)ghr ([Dpr(N-octanoyl)(3)] ghrelin) (Dpr - diaminopropionic acid), YA GHRP-6 (H-Tyr-Ala-His-DTrp-Ala-Trp-DPhe-L...

journal_title：Neurochemistry international

authors： Pirnik Z,Bundziková J,Holubová M,Pýchová M,Fehrentz JA,Martinez J,Zelezná B,Maletínská L,Kiss A

更新日期：2011-11-01 00:00:00

abstract：:The present study has been designed to establish the potential benefits from 1-methylnicotinamide (MNA) treatment on brain disorders associated with type 1 diabetes. All experiments were carried out after 6 weeks of streptozotocin-induced diabetes (60 mg/kg of body weight, i.p.) in male Wistar rats treated for 5 weeks...

journal_title：Neurochemistry international

authors： Kuchmerovska T,Shymanskyy I,Chlopicki S,Klimenko A

更新日期：2010-01-01 00:00:00

abstract：:Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT(2A)) have been related to depression pathology. Specific 5-HT(2A) receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT(2A) receptor level. Here we show a direct effect of BDNF on 5-HT(2A) receptor pr...

journal_title：Neurochemistry international

authors： Trajkovska V,Santini MA,Marcussen AB,Thomsen MS,Hansen HH,Mikkelsen JD,Arneberg L,Kokaia M,Knudsen GM,Aznar S

更新日期：2009-12-01 00:00:00