听力与言语-语言病理学

行为科学

医学伦理学

你正在浏览NEUROCHEMISTRY INTERNATIONAL期刊下所有文献
  • Identification of secreted factors in dental pulp cell-conditioned medium optimized for neuronal growth.

    abstract::With their potent regenerative and protective capacities, stem cell-derived conditioned media emerged as an effective alternative to cell therapy, and have a prospect to be manufactured as pharmaceutical products for tissue regeneration applications. Our study investigates the neuroregenerative potential of human dent...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2021.104961

    authors: Chouaib B,Collart-Dutilleul PY,Blanc-Sylvestre N,Younes R,Gergely C,Raoul C,Scamps F,Cuisinier F,Romieu O

    更新日期:2021-01-16 00:00:00

  • Understanding the epigenetic landscape and cellular architecture of childhood brain tumors.

    abstract::Pediatric brain tumors are the leading cancer-related cause of death in children and adolescents in the United States, affecting on average 1 in 2000 children per year. Recent advances in cancer genomics have led to profound discoveries about the underlying molecular biology and ontogeny of these tumors. In particular...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104940

    authors: Alencastro Veiga Cruzeiro G,Rota C,Hack OA,Segal R,Filbin MG

    更新日期:2020-12-15 00:00:00

  • Does a hypoxic injury from a non-fatal overdose lead to an Alzheimer Disease?

    abstract::Long term consequence of non-fatal overdose in people who use opioids are not well understood. The intermittent exposure to non-fatal overdose leads to a tauopathy that is often accompanied by abrogated neuroprotective response, abnormal amyloid processing and other pathologies. The scope and limitations of available ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2020.104936

    authors: Voronkov M,Cocchiaro B,Stock JB

    更新日期:2020-12-10 00:00:00

  • Scn1a and Cacna1a mutations mutually alter their original phenotypes in rats.

    abstract::This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104859

    authors: Ohmori I,Kobayashi K,Ouchida M

    更新日期:2020-12-01 00:00:00

  • Bench to bedside: Multiple facets of cannabinoid control in epilepsy.

    abstract::Epilepsy is a neurological disease recognized as the consequence of excessive neuronal excitability. Endocannabinoid system, the critical regulator of synaptic inhibition in brain, was supposed to be closely involved in epilepsy. Cannabinoid receptors mostly locate on presynaptic terminals of both excitatory and inhib...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2020.104898

    authors: Xue B,Zhang X,Wang Y

    更新日期:2020-12-01 00:00:00

  • Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor.

    abstract::Acetylcholinesterase (AChE) hydrolyses acetylcholine to choline and acetate, playing an important role in terminating the neurotransmission in brain and muscle. Recently, the non-neuronal functions of AChE have been proposed in different tissues, in which there are various factors to regulate the expression of AChE. I...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104861

    authors: Wu Q,Bai P,Xia Y,Lai QWS,Guo MSS,Dai K,Zheng Z,Ling CSJ,Dong TTX,Pi R,Tsim KWK

    更新日期:2020-12-01 00:00:00

  • Secreted gingipains from Porphyromonas gingivalis induce microglia migration through endosomal signaling by protease-activated receptor 2.

    abstract::Much attention has been paid to the connection between periodontitis and Alzheimer's disease (AD). We previously showed that infection of P. gingivalis, one of major periodontal pathogen causing periodontitis, induced migration and inflammatory responses in murine microglia through gingipain-induced activation of prot...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104840

    authors: Nonaka S,Nakanishi H

    更新日期:2020-11-01 00:00:00

  • Repeated phencyclidine disrupts nicotinic acetylcholine regulation of dopamine release in nucleus accumbens: Implications for models of schizophrenia.

    abstract::Dopaminergic dysregulation in nucleus accumbens has been implicated in the origin of schizophrenia. Accumbal cholinergic interneurons exert powerful modulatory control of local dopamine function, through nicotinic receptors located on dopamine terminals. Fast-scan cyclic voltammetry in rat brain slices in vitro was us...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104836

    authors: Yavas E,Young AMJ

    更新日期:2020-11-01 00:00:00

  • Novel Drosophila model for parkinsonism by targeting phosphoglycerate kinase.

    abstract::Patients with Parkinson's disease (PD) show a common progressive neurodegenerative movement disorder characterized by rigidity, tremors, postural instability, and bradykinesia due to the loss of dopaminergic neurons in the substantia nigra, and is often accompanied by several non-motor symptoms, called parkinsonism. S...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104816

    authors: Shimizu J,Kasai T,Yoshida H,Huynh AM,Nakao-Azuma Y,Shinomoto M,Tokuda T,Mizuno T,Yamaguchi M

    更新日期:2020-10-01 00:00:00

  • The role of neutrophils in mediating stroke injury in the diabetic db/db mouse brain following hypoxia-ischemia.

    abstract::Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104790

    authors: Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

    更新日期:2020-10-01 00:00:00

  • Glutamate-responsive translation of dendritic GSK3β mRNA triggers a cycle for amplification of reactivated preexisting GSK3β that is indispensable for tau hyperphosphorylation.

    abstract::The molecular mechanism responsible for hyperphosphorylated tau accumulation in dendrites of Alzheimer's disease (AD) neurons has not been fully clarified. Recently, we reported that tau mRNA is distributed into dendrites, and that translation and phosphorylation of tau protein are immediately enhanced in response to ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104808

    authors: Tanaka T,Ohashi S,Takashima A,Kobayashi S

    更新日期:2020-10-01 00:00:00

  • Redox-active DJ-1 sustains brainstem cardiovascular regulation via maintenance of mitochondrial function during mevinphos intoxication.

    abstract::DJ-1 (also known as PARK7) is a redox-active protein that protects against oxidative stress. This study evaluated the hypothesis that DJ-1 sustains brainstem cardiovascular regulation via maintaining mitochondrial function in the rostral ventrolateral medulla (RVLM), a brainstem site known to maintain blood pressure a...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104791

    authors: Tsai CY,Wu CJ,Wu JCC,Fang C,Huang YH,Dai KY

    更新日期:2020-10-01 00:00:00

  • Effects of ghrelin on the electrical activities of substantia nigra dopaminergic neurons treated with MPP.

    abstract::Ghrelin, a 28 amino acid brain-gut peptide, has attracted increasing attention for its neuroprotective effect in Parkinson's disease (PD). In view of the pivotal role of excitability of dopaminergic neurons in substantia nigra pars compacta (SNc) in the function of nigrostriatal system, it is of great significance to ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104780

    authors: Chang X,Ma Z,Shi L,Xie J

    更新日期:2020-09-01 00:00:00

  • Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine.

    abstract::Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. Further, the efficacy of Lanicemine, a low trapping ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104750

    authors: Mishra PK,Adusumilli M,Deolal P,Mason GF,Kumar A,Patel AB

    更新日期:2020-07-01 00:00:00

  • Postnatal functional inactivation of the ventral subiculum enhances dopaminergic responses in the core part of the nucleus accumbens following ketamine injection in adult rats.

    abstract::For almost two decades schizophrenia has been considered to be a functional disconnection disorder. This functional disconnectivity between several brain regions could have a neurodevelopmental origin. Various approaches suggest the ventral subiculum (SUB) is a particular target region for neurodevelopemental disturba...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104736

    authors: Saoud H,De Beus D,Eybrard S,Louilot A

    更新日期:2020-07-01 00:00:00

  • Nonlinear and mixed inhibitory effect of matrine on the cytotoxicity of oligomeric amyloid-β protein.

    abstract::The formation of amyloid β-protein (1-42) (Aβ42) oligomers and Aβ42 oligomer cytotoxicity are two defining characteristics of the etiology of Alzheimer's disease (AD). In this study, we found that matrine (Mat) could maintain or even enhance the cytotrophic effect of Aβ42 monomers by inhibiting their aggregation and b...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104746

    authors: Yang B,Li H,Zhang T,Wang Z,Li H,Zhang Y

    更新日期:2020-07-01 00:00:00

  • Rapid identification of a novel phosphodiesterase 7B tracer for receptor occupancy studies using LC─MS/MS.

    abstract::Phosphodiesterase 7B (PDE7B) inhibition has been considered as a therapeutic target for the treatment of several neurological disorders. Currently, there are no radio-labeled tracers available to determine receptor occupancy (RO) of this target. Developing such a tracer could greatly facilitate the identification of v...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104735

    authors: Chen J,Gu G,Chen M,Scott T,Heger L,Zook D,Chung D,Keenan T,Renick J,Santora VJ,Vivian J,Stauber K,Breitenbucher JG,Tabatabaei A

    更新日期:2020-07-01 00:00:00

  • Connexins in oligodendrocytes and astrocytes: Possible factors for demyelination in multiple sclerosis.

    abstract::Increasing evidences support that glial connexins are involved in the demyelination pathology of multiple sclerosis (MS), a chronic inflammatory demyelinating disorder. Here, we review the data from patients with MS and animal models of MS that implicate connexins in demyelination. Connexins expressed in oligodendrocy...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2020.104731

    authors: Xia CY,Xu JK,Pan CH,Lian WW,Yan Y,Ma BZ,He J,Zhang WK

    更新日期:2020-06-01 00:00:00

  • Neuroinflammation: An overview of neurodegenerative and metabolic diseases and of biotechnological studies.

    abstract::Neuroinflammation is an important factor contributing to cognitive impairment and neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), ischemic injury, and multiple sclerosis (MS). These diseases are characterized by inexorable progressive injur...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2020.104714

    authors: de Araújo Boleti AP,de Oliveira Flores TM,Moreno SE,Anjos LD,Mortari MR,Migliolo L

    更新日期:2020-06-01 00:00:00

  • Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish.

    abstract::Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a possible neuroprotective role of taurine against MK-801-induced mem...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2020.104710

    authors: Franscescon F,Müller TE,Bertoncello KT,Rosemberg DB

    更新日期:2020-05-01 00:00:00

  • PDE9 inhibition promotes proliferation of neural stem cells via cGMP-PKG pathway following oxygen-glucose deprivation/reoxygenation injury in vitro.

    abstract::Cerebral ischemia is one of leading causes of death and long-term disability worldwide. Stem cell-based therapy is promising some valuable strategies for the structural and functional recovery after ischemic insult. The inhibition of phosphodiesterases (PDEs) has wide spectrum neuroprotective properties by stimulating...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104630

    authors: Huan X,Oumei C,Hongmei Q,Junxia Y,Xiaojiao M,Qingsong J

    更新日期:2020-02-01 00:00:00

  • Xanthohumol, an active constituent from hope, affords protection against kainic acid-induced excitotoxicity in rats.

    abstract::Excitotoxicity induced by excessive glutamate has been implicated in many brain disorders. Xanthohumol is a natural product derived from hops (Humulus lupulus L.), which is reported to have glutamate release-inhibiting activity. However, it is unknown whether xanthohumol has protective effects against glutamate-induce...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104629

    authors: Wang CC,Ho YH,Hung CF,Kuo JR,Wang SJ

    更新日期:2020-02-01 00:00:00

  • Polarized hemichannel opening of pannexin 1/connexin 43 contributes to dysregulation of transport function in blood-brain barrier endothelial cells.

    abstract::Dysregulation of blood-brain barrier (BBB) transport exacerbates brain damage in acute ischemic stroke. Here, we aimed to investigate the mechanism of this BBB transport dysregulation by studying the localization and function of pannexin (Px) and connexin (Cx) hemichannels in blood-brain barrier endothelial cells of r...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104600

    authors: Tachikawa M,Murakami K,Akaogi R,Akanuma SI,Terasaki T,Hosoya KI

    更新日期:2020-01-01 00:00:00

  • N-acetyl cysteine ameliorates depression-induced cognitive deficits by restoring the volumes of hippocampal subfields and associated neurochemical changes.

    abstract::Depression is highly comorbid with anxiety disorders and associated with profound cognitive impairment. Moreover, cognitive deficits associated with hippocampal dysfunction are central in depression and anxiety disorders. Furthermore, depression is accompanied by glutamatergic dysfunction which can further impair the ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104605

    authors: Chakraborty S,Tripathi SJ,Srikumar BN,Raju TR,Shankaranarayana Rao BS

    更新日期:2020-01-01 00:00:00

  • Developmental impact of air pollution on brain function.

    abstract::Air pollution is an important contributor to the global burden of disease, particularly to respiratory and cardiovascular diseases. In recent years, evidence is accumulating that air pollution may adversely affect the nervous system as shown by human epidemiological studies and by animal models. Age appears to play a ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2019.104580

    authors: Costa LG,Cole TB,Dao K,Chang YC,Garrick JM

    更新日期:2019-12-01 00:00:00

  • Txnip mediates glucocorticoid-activated NLRP3 inflammatory signaling in mouse microglia.

    abstract::Many studies indicate that chronic stress and excessive stress hormone can cause an inflammatory response. Thioredoxin-interacting protein (Txnip) as an endogenous thioredoxin inhibitor suppresses thioredoxin-produced antioxidant effects. Txnip was also found to interact with nucleotide-binding oligomerization domain-...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104564

    authors: Bharti V,Tan H,Zhou H,Wang JF

    更新日期:2019-12-01 00:00:00

  • The P2Y14 receptor in the trigeminal ganglion contributes to the maintenance of inflammatory pain.

    abstract::P2Y purinergic receptors expressed in neurons and satellite glial cells (SGCs) of the trigeminal ganglion (TG) contribute to inflammatory and neuropathic pain. P2Y14 receptor expression is reported in the spinal cord, dorsal root ganglion (DRG), and TG. In present study, the role of P2Y14 receptor in the TG in inflamm...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104567

    authors: Lin J,Zhang YY,Liu F,Fang XY,Liu MK,Huang CL,Wang H,Liao DQ,Zhou C,Shen JF

    更新日期:2019-12-01 00:00:00

  • Lercanidipine boosts the efficacy of mesenchymal stem cell therapy in 3-NP-induced Huntington's disease model rats via modulation of the calcium/calcineurin/NFATc4 and Wnt/β-catenin signalling pathways.

    abstract::3-Nitropropionic acid (3-NP) induces a spectrum of Huntington's disease (HD)-like neuropathologies in the rat striatum. The present study aimed to demonstrate the neuroprotective effect of lercanidipine (LER) in rats with 3-NP-induced neurotoxicity, address the possible additional protective effect of combined treatme...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104548

    authors: Elbaz EM,Helmy HS,El-Sahar AE,Saad MA,Sayed RH

    更新日期:2019-12-01 00:00:00

  • Clinical spectrum of inflammatory central nervous system demyelinating disorders associated with antibodies against myelin oligodendrocyte glycoprotein.

    abstract::Immunoglobulin G (IgG) antibodies against myelin oligodendrocyte glycoprotein (MOG) are detected in the serum of some patients with demyelinating diseases. These patients are known to show repeated clinical episodes of inflammatory demyelinating attacks in the central nervous system. Although the associated pathogenic...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2018.10.016

    authors: Akaishi T,Sato DK,Takahashi T,Nakashima I

    更新日期:2019-11-01 00:00:00

  • Inflammation and neural repair after ischemic brain injury.

    abstract::Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-reso...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2018.10.013

    authors: Sakai S,Shichita T

    更新日期:2019-11-01 00:00:00

  • Eomes-expressing T-helper cells as potential target of therapy in chronic neuroinflammation.

    abstract::Reserch progresses in understanding the pathogenicity of multiple sclerosis (MS) in the last couple of decade has enabled us to develop new drug entities available in the clinic. However, we still have not succeeded in preventing conversion from relapsing-remitting MS (RR-MS) to secondary progressive MS (SP-MS) and cu...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2018.11.023

    authors: Oki S

    更新日期:2019-11-01 00:00:00

  • The adenosine A2A receptor antagonist SCH58261 reduces macrophage/microglia activation and protects against experimental autoimmune encephalomyelitis in mice.

    abstract::Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104490

    authors: Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

    更新日期:2019-10-01 00:00:00

  • Glutaminase activity in GLS1 Het mouse brain compared to putative pharmacological inhibition by ebselen using ex vivo MRS.

    abstract::Glutaminase mediates the recycling of neurotransmitter glutamate, supporting most excitatory neurotransmission in the mammalian central nervous system. A constitutive heterozygous reduction in GLS1 engenders in mice a model of schizophrenia resilience and associated increases in Gln, reductions in Glu and activity-dep...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104508

    authors: Kosten L,Chowdhury GMI,Mingote S,Staelens S,Rothman DL,Behar KL,Rayport S

    更新日期:2019-10-01 00:00:00

  • Repeated exposure to methiopropamine increases dendritic spine density in the rat nucleus accumbens core.

    abstract::Repeated exposure to classical psychomotor stimulants, like amphetamine (AMPH), produces locomotor sensitization and accompanied structural plasticity of dendritic spines in the nucleus accumbens (NAcc). Following our previous report that repeated administration of methiopropamine (MPA), a structural analog to meth-AM...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104487

    authors: Cai WT,Yoon HS,Lee S,Kim JH

    更新日期:2019-10-01 00:00:00

  • The unresolved role of mitochondrial DNA in Parkinson's disease: An overview of published studies, their limitations, and future prospects.

    abstract::Parkinson's disease (PD), a progressive neurodegenerative disorder, has long been associated with mitochondrial dysfunction in both sporadic and familial forms of the disease. Mitochondria are crucial for maintaining cellular homeostasis, and their dysfunction is detrimental to dopaminergic neurons. These neurons are ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuint.2019.104495

    authors: Müller-Nedebock AC,Brennan RR,Venter M,Pienaar IS,van der Westhuizen FH,Elson JL,Ross OA,Bardien S

    更新日期:2019-10-01 00:00:00

  • Ammonium induced dysfunction of 5-HT2B receptor in astrocytes.

    abstract::Previously we reported that gene expression of astrocytic 5-HT2B receptors was decreased in brains of depressed animals exposed to chronic mild stress (CMS) (Li et al., 2012) and of Parkinson's disease (Song et al., 2018). Depression is also one of the psychiatric symptoms in hyperammonemia, and astrocyte is a primary...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.104479

    authors: Yue T,Li B,Gu L,Huang J,Verkhratsky A,Peng L

    更新日期:2019-10-01 00:00:00

  • Activation of liver x receptors prevents the spinal LTP induced by skin/muscle retraction in the thigh via SIRT1/NF-Κb pathway.

    abstract::It has been reported that skin/muscle incision and retraction (SMIR) in the thigh, produces mechanical allodynia in the hind paw, far from the site of incision/retraction. The mechanical allodynia lasts about 22 days, indicating chronic post-operative pain develops. The precise mechanisms, however, are largely unclear...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.04.002

    authors: Zhong X,Wang W,Mao Z,Gao F,Guo R,Wei X,Liu X,Wei X

    更新日期:2019-09-01 00:00:00

  • Streptozotocin causes acute responses on hippocampal S100B and BDNF proteins linked to glucose metabolism alterations.

    abstract::Streptozotocin (STZ) is a glucosamine-nitrosourea commonly used to induce long-lasting models of diabetes mellitus and Alzheimer's disease. Direct toxicity of STZ on the pancreas and kidneys has been well characterized, but the acute effect of this compound on brain tissue has received less attention. Herein, we inves...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.04.013

    authors: Rodrigues L,Wartchow KM,Suardi LZ,Federhen BC,Selistre NG,Gonçalves CA

    更新日期:2019-09-01 00:00:00

  • Sildenafil treatment of vascular dementia in aged rats.

    abstract:BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2018.12.015

    authors: Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

    更新日期:2019-07-01 00:00:00

  • Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway.

    abstract::Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章

    doi:10.1016/j.neuint.2019.03.006

    authors: Sun YJ,Ma S,Fan B,Wang Y,Wang SR,Li GY

    更新日期:2019-06-01 00:00:00

606 条记录 1/16 页 « 12345678...1516 »