Fluorescence studies of endothelin-1.

abstract：:It was shown previously that pure oligodendrocytes release proteins when maintained in a chemically defined medium. Among these proteins, a 53 kDa glycoprotein was characterized as a component accessible from the external surface of these glial cells. Specific antibodies directed against this glycoprotein were obtaine...

journal_title：Neurochemistry international

authors： Pari FM,Roussel G,Nussbaum F,Nussbaum JL

更新日期：1988-01-01 00:00:00

abstract：:Electroacupuncture has been shown to induce a preconditioning effect in the brain. The mechanisms for this protection are not fully elucidated. We hypothesize that this protection is mediated by excitatory amino acid transporters (EAATs) that have been shown to be neuroprotective. To test this hypothesis, two-month ol...

journal_title：Neurochemistry international

authors： Zhu X,Yin J,Li L,Ma L,Tan H,Deng J,Chen S,Zuo Z

更新日期：2013-10-01 00:00:00

abstract：:In this report evidence is presented for a membrane-associated polypeptide that regulates ligand binding properties of a neuronal acetylcholine receptor. Removal of membrane-associated compounds reversibly increased the number of BGTX binding sites and decreased the number of binding sites for ACh in neuronal membrane...

journal_title：Neurochemistry international

authors： Benke D,Breer H

更新日期：1990-01-01 00:00:00

abstract：:A single molecular species of GTP-binding protein (G protein) has been purified from the bovine cerebral cortex. The immunoblot analysis indicated that the isolated G protein might be Gi1 or Gi2 but not Go, since it was reacted by specific antibodies, anti-Gi alpha 1-2 and anti-Gi alpha 1-1, but not anti-Go alpha. Whe...

journal_title：Neurochemistry international

authors： Nishikawa M,Hirouchi M,Kuriyama K

更新日期：1997-07-01 00:00:00

abstract：:Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a possible neuroprotective role of taurine against MK-801-induced mem...

journal_title：Neurochemistry international

authors： Franscescon F,Müller TE,Bertoncello KT,Rosemberg DB

更新日期：2020-05-01 00:00:00

abstract：:Alzheimer's disease has long been associated with increased inflammation in the brain. Activated microglia and increased production of the inflammatory cytokines such as TNF-α, have been proposed to contribute to the onset and progression of the disease. We investigated if systemic administration of an anti-tumor necr...

journal_title：Neurochemistry international

authors： Detrait ER,Danis B,Lamberty Y,Foerch P

更新日期：2014-06-01 00:00:00

abstract：:NaIO(4) oxidation, exo- and endo-glycosidase treatments and combinations thereof have been applied to acetylcholine receptor from Torpedo marmorata in its membrane-bound and detergent-solubilised forms. The effects of these chemical and enzymatic treatments are made apparent in the electrophoretic properties of the fo...

journal_title：Neurochemistry international

authors： Criado M,Barrantes FJ

更新日期：1982-01-01 00:00:00

abstract：:The worldwide prevalence of stroke continues to rise despite recent successes in treating acute ischemic stroke. With limited patient eligibility and associated risk of tPA and mechanical thrombectomy, new preventive and therapeutic modalities are needed to stave the rising wave of stroke. Inflammation plays a key rol...

journal_title：Neurochemistry international

authors： Benedek G,Vandenbark AA,Alkayed NJ,Offner H

更新日期：2017-07-01 00:00:00

abstract：:It is well established that histaminergic neurons in the posterior hypothalamus make connections with whole brain areas and regulate several functions. Recent evidence indicates that histaminergic neurons are heterogeneous cell group and organized into distinct circuits. However, functional circuits of histaminergic n...

journal_title：Neurochemistry international

authors： Umehara H,Mizuguchi H,Fukui H

更新日期：2012-11-01 00:00:00

abstract：:Recently, a new experimental model of epilepsy was introduced by the authors [Neurochem. Int. 40 (2002) 413]. This model combines pentylenetetrazole (PTZ)-kindling in senescence-accelerated mice P8 (SAMP8), a genetic model of aging. Since imbalance of glutamate and GABA is a major cause of seizures, the study of glial...

journal_title：Neurochemistry international

authors： Kondziella D,Hammer J,Sletvold O,Sonnewald U

更新日期：2003-12-01 00:00:00

abstract：:Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

journal_title：Neurochemistry international

authors： Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

更新日期：2009-12-01 00:00:00

abstract：:D1 dopamine receptors have been localized using a radioactive form of a new specific antagonist, [3H]SCH39166. This compound has been shown, in in vitro binding studies, to be highly selective for the D1 receptor subtype; more so than its predecessor, [3H]SCH23390. These ligand binds saturably, reversibly and with hig...

journal_title：Neurochemistry international

authors： Wamsley JK,Alburges ME,McQuade RD,Hunt M

更新日期：1992-03-01 00:00:00

abstract：:Inflammation which is an indispensable participant in tumor progression is intricately linked with redox modulation. The pro-inflammatory cytokine Tumor Necrosis Factor (TNFalpha) elevates reactive oxygen species (ROS) in glioblastoma multiforme (GBM). As both TNFalpha and oxidative stress independently play role in r...

journal_title：Neurochemistry international

authors： Ghosh S,Tewari R,Dixit D,Sen E

更新日期：2010-01-01 00:00:00

abstract：:To elucidate the role of Ca(2+)-activated K(+) (K(Ca)) channels in the presynaptic acetylcholine (ACh) release from splanchnic nerve endings and the postsynaptic catecholamine release from chromaffin cells, we applied microdialysis technique to the left adrenal medulla of anesthetized rats and investigated the effects...

journal_title：Neurochemistry international

authors： Akiyama T,Yamazaki T,Kawada T,Shimizu S,Sugimachi M,Shirai M

更新日期：2010-01-01 00:00:00

abstract：:Neuroserpin, the major inhibitor of tissue plasminogen activator (tPA) in brain, has been shown to be up-regulated in Alzheimer's disease (AD). Inhibition of tPA activity leads to reduced brain levels of plasmin, one of the main enzymes responsible for the degradation and clearance of amyloid-beta and its plaques from...

journal_title：Neurochemistry international

authors： Subhadra B,Schaller K,Seeds NW

更新日期：2013-11-01 00:00:00

abstract：:Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissue-specific manifest...

journal_title：Neurochemistry international

authors： Byrnes J,Ganetzky R,Lightfoot R,Tzeng M,Nakamaru-Ogiso E,Seiler C,Falk MJ

更新日期：2018-07-01 00:00:00

abstract：:Although many studies have revealed alterations in neurotransmission during ischaemia, few works have been devoted to the neurochemical effects of mild hypoxia, a situation encountered during life in altitude or in several pathologies. In that context, the present work was undertaken to determine the in vivo mechanism...

journal_title：Neurochemistry international

authors： Orset C,Parrot S,Sauvinet V,Cottet-Emard JM,Bérod A,Pequignot JM,Denoroy L

更新日期：2005-06-01 00:00:00

abstract：:Agomelatine is a novel antidepressant with agonistic actions at melatonergic (MT1 and MT2 receptors) and antagonistic actions at 5HT-2C receptors. Venlafaxine, a serotonin norepinephrine reuptake inhibitor, is a widely prescribed drug in depression. The present study evaluated the low dose combinations of venlafaxine ...

journal_title：Neurochemistry international

authors： Thomas J,Khanam R,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:Pyrrolidinedithiocarbamate (PDTC) is a compound displaying antioxidant, pro-oxidant and metal chelator properties in different cell types. It has been described that PDTC may exert either anti-apoptotic or apoptotic activity. Moreover it is known that this agent regulates the activity of redox-sensitive transcription ...

journal_title：Neurochemistry international

authors： Porcile C,Stanzione S,Piccioli P,Bajetto A,Barbero S,Bisaglia M,Bonavia R,Florio T,Schettini G

更新日期：2003-07-01 00:00:00

abstract：:Activation of astrocytes occurs during many forms of CNS injury, but its importance for neuronal survival is poorly understood. When hippocampal cultures of neurons and astrocytes were treated from day 2-4 in vitro (DIV 2-4) with 1 microM cytosine arabinofuranoside (AraC), we observed a stellation of astrocytes, an in...

journal_title：Neurochemistry international

authors： Ahlemeyer B,Kölker S,Zhu Y,Hoffmann GF,Krieglstein J

更新日期：2003-06-01 00:00:00

abstract：:Cholinergic neuroblastoma NS20Y cells were differentiated by the chicken gizzard extract. They were first inoculated into a glass culture bottle and the aggregated cells which grew in the suspension culture were collected. The aggregated cells (round and immature neuroblastoma cells) were seeded on a polyornithinecoat...

journal_title：Neurochemistry international

authors： Miki N,Higashida H,Hayashi Y,Akiyama M,Kuo CH

更新日期：1982-01-01 00:00:00

abstract：:Glutathione (GSH) is an essential component of intracellular antioxidant systems that plays a primordial role in the protection of cells against oxidative stress, maintaining redox homeostasis and xenobiotic detoxification. GSH synthesis in the brain is limited by the availability of cysteine and glutamate. Cystine, t...

journal_title：Neurochemistry international

authors： Garza-Lombó C,Petrosyan P,Tapia-Rodríguez M,Valdovinos-Flores C,Gonsebatt ME

更新日期：2018-12-01 00:00:00

abstract：:Chronic variate stress was seen to decrease the ingestion of sweet food when compared to control rats. Brain monoamines are known to be involved in the control of food intake, serotonin appears to be involved in the mechanisms of satiety, and dopamine in mediating appetite or approach behaviors triggered by incentive ...

journal_title：Neurochemistry international

authors： Gamaro GD,Manoli LP,Torres IL,Silveira R,Dalmaz C

更新日期：2003-01-01 00:00:00

abstract：:Astrocytes, the most versatile cells of the central nervous system, play an important role in the regulation of neurotransmitter homeostasis, energy metabolism, antioxidant defenses and the anti-inflammatory response. Recently, our group characterized cortical astrocyte cultures from adult Wistar rats. In line with th...

journal_title：Neurochemistry international

authors： Souza DG,Bellaver B,Raupp GS,Souza DO,Quincozes-Santos A

更新日期：2015-11-01 00:00:00

abstract：:A significant loss of dopamine was found in rat striatal slices incubated with 1-methyl-4-phenylpyridinium ion (MPP+) at a concentration of 2 microM or higher. The addition of 7-nitroindazole, a specific inhibitor of neuronal nitric oxide synthase (nNOS), prevented this effect on dopamine when the concentration of MPP...

journal_title：Neurochemistry international

authors： Cutillas B,Espejo M,Ambrosio S

更新日期：1998-07-01 00:00:00

abstract：:The present experiments investigated the effect of a neurotoxin purified from the venom of the spider Phoneutria nigriventer. This toxic component, P. nigriventer toxin 3-6 (PnTx3-6), abolished Ca(2+)-dependent glutamate release with an IC(50) of 74.4nM but did not alter Ca(2+)-independent secretion of glutamate when ...

journal_title：Neurochemistry international

authors： Vieira LB,Kushmerick C,Reis HJ,Diniz CR,Cordeiro MN,Prado MA,Kalapothakis E,Romano-Silva MA,Gomez MV

更新日期：2003-03-01 00:00:00

abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

journal_title：Neurochemistry international

authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

更新日期：1993-08-01 00:00:00

abstract：:Dopamine is the main catecholamine found in the chick retina whereas norepinephrine is only found in trace amounts. We compared the effectiveness of dopamine and norepinephrine in promoting cyclic AMP accumulation in retinas at embryonic day 13 (E13) and from post-hatched chicken (P15). Dopamine (EC(50)=10microM) and ...

journal_title：Neurochemistry international

authors： Kubrusly RC,Ventura AL,de Melo Reis RA,Serra GC,Yamasaki EN,Gardino PF,de Mello MC,de Mello FG

更新日期：2007-01-01 00:00:00

abstract：:Diisopropyl phosphorofluoridate (DFP) produces Type I organophosphorus compound-induced delayed neurotoxicity (OPIDN) in adult female chickens. We have proposed that calcium/calmodulin protein kinase II (CaM kinase II) plays a role in the development of OPIDN by increasing the phosphorylation of cytoskeletal proteins....

journal_title：Neurochemistry international

authors： Abou-Donia MB,Viana ME,Gupta RP,Anderson JK

更新日期：1993-02-01 00:00:00

abstract：:There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

journal_title：Neurochemistry international

authors： Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

更新日期：2017-09-01 00:00:00