Role of Ca2+-activated K+ channels in catecholamine release from in vivo rat adrenal medulla.

abstract：:Immunohistochemical study on growth inhibitory factor (GIF) in rat brain has revealed that a glial cell layer on the surface of cerebral cortex and the cells surrounding Purkinje cells has been reported. In addition, neurons in gray matter were weakly immunostained for GIF. In situ hybridization using digoxigenin-labe...

journal_title：Neurochemistry international

authors： Anezaki T,Ishiguro H,Hozumi I,Inuzuka T,Hiraiwa M,Kobayashi H,Yuguchi T,Wanaka A,Uda Y,Miyatake T

更新日期：1995-07-01 00:00:00

abstract：:Human neuroblastoma GOTO cell lines were established that stably express recombinant human lysosomal protective protein/cathepsin A (PPCA) cDNA by transfection. Intracellular cathepsin A (acid serine carboxypeptidase) activity increased four-fold compared with in those of the parent and mock-transfected cell lines. Th...

journal_title：Neurochemistry international

authors： Itoh K,Satoh Y,Kadota Y,Oheda Y,Kuwahara J,Shimmoto M,Sakuraba H

更新日期：2004-05-01 00:00:00

abstract：:Tissue preparations from the brain of rats and guinea-pigs were examined for their activity in binding isotopically labelled colchicine, as a measure of their content of tubulin. The amount of binding material extracted into a cold buffered solution was unaffected by keeping tissues at 0 degrees C. It diminished by on...

journal_title：Neurochemistry international

authors： McIlwain H,Poll JD

更新日期：1983-01-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:Epilepsy is a neurological disease recognized as the consequence of excessive neuronal excitability. Endocannabinoid system, the critical regulator of synaptic inhibition in brain, was supposed to be closely involved in epilepsy. Cannabinoid receptors mostly locate on presynaptic terminals of both excitatory and inhib...

journal_title：Neurochemistry international

authors： Xue B,Zhang X,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:A sandwich enzyme immunoassay (EIA) was established by using purified human serum dopamine-?-hydroxylase (DBH) as a standard protein and a monospecific polyclonal antibody raised against human DBH purified from human pheochromocytoma. The EIA was applied to measuring DBH levels in human CSF from Parkinsonian patients ...

journal_title：Neurochemistry international

authors： Mogi M,Harada M,Kojima K,Inagaki H,Kondo T,Narabayashi H,Arai T,Teradaira R,Fujita K,Kiuchi K,Nagatsu T

更新日期：1988-01-01 00:00:00

abstract：:The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8-10 weeks old male C57BL/6 wild-type mic...

journal_title：Neurochemistry international

authors： Mondal NK,Behera J,Kelly KE,George AK,Tyagi PK,Tyagi N

更新日期：2019-01-01 00:00:00

abstract：:Therapeutic hypothermia as a physical method to lower the brain temperature of patients has been widely used in clinics as an effective and necessary step during the treatment of acute brain injury or edema. However, due to limitations of the ocular structure, the application of hypothermia in retinal neuroprotection ...

journal_title：Neurochemistry international

authors： Sun YJ,Ma S,Fan B,Wang Y,Wang SR,Li GY

更新日期：2019-06-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:The acylation of myelin proteolipid protein (PLP) and intermediate protein (IP) was investigated in an in vitro system of tissue slices prepared from actively myelinating rat brainstem. The incorporation of [(3)H]palmitate into the proteins in nine subcellular fractions including myelin and other cellular membranes wh...

journal_title：Neurochemistry international

authors： Konat G,Gantt G,Hogan EL

更新日期：1986-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases in subjects over 65 years of age. Several postulates have been put forward that relate AD neuropathology to intellectual and functional impairment. These range from free-radical-induced damage, through cholinergic dysfunction,...

journal_title：Neurochemistry international

authors： Hynd MR,Scott HL,Dodd PR

更新日期：2004-10-01 00:00:00

abstract：:Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic and by stimulating glutamatergic neurotransmission. PREGS is also a potent modulator of sigma type 1 (sigma1) receptors. It has been proposed that these actions o...

journal_title：Neurochemistry international

authors： Schumacher M,Liere P,Akwa Y,Rajkowski K,Griffiths W,Bodin K,Sjövall J,Baulieu EE

更新日期：2008-03-01 00:00:00

abstract：:In the past few years, several studies have demonstrated in the rat subcommissural organ the presence of nerve endings and modified ependymocytes showing an uptake of [(3)H]GABA. The present work was performed to demonstrate in this cerebral zone the possibility of a GABA synthesis by the immunohistochemical localizat...

journal_title：Neurochemistry international

authors： Weissmann-Nanopoulos D,Belin MF,Didier M,Aguera M,Partisani M,Maitre M,Pujol JF

更新日期：1983-01-01 00:00:00

abstract：:Dysregulation of blood-brain barrier (BBB) transport exacerbates brain damage in acute ischemic stroke. Here, we aimed to investigate the mechanism of this BBB transport dysregulation by studying the localization and function of pannexin (Px) and connexin (Cx) hemichannels in blood-brain barrier endothelial cells of r...

journal_title：Neurochemistry international

authors： Tachikawa M,Murakami K,Akaogi R,Akanuma SI,Terasaki T,Hosoya KI

更新日期：2020-01-01 00:00:00

abstract：:Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

journal_title：Neurochemistry international

authors： Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

更新日期：2008-12-01 00:00:00

abstract：:Neural stem cells (NSCs) play a crucial role in the development and maturation of the central nervous system. Recently studies suggest that antipsychotic drugs regulate the activities of NSCs. However, the molecular mechanisms underlying antipsychotic-induced changes of the activity of NSCs, particularly protein expre...

journal_title：Neurochemistry international

authors： Kashem MA,Ummehany R,Ukai W,Hashimoto E,Saito T,Mcgregor IS,Matsumoto I

更新日期：2009-12-01 00:00:00

abstract：:Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported that the C-terminus of SERT interacts with MacMARCKS, a substrate of PKC that can bind to the actin cytoskeleton. To elucidate the importance of the C-terminal reg...

journal_title：Neurochemistry international

authors： Mochizuki H,Amano T,Seki T,Matsubayashi H,Mitsuhata C,Morita K,Kitayama S,Dohi T,Mishima HK,Sakai N

更新日期：2005-01-01 00:00:00

abstract：:Mecamylamine is a well-described non specific antagonist of nicotinic acetylcholine receptors (nAChRs), used in therapy and in psychopharmacological studies. [(11)C]-Mecamylamine was prepared and evaluated as a putative radioligand for positron emission tomography to study nicotinic acetylcholine receptors. The radios...

journal_title：Neurochemistry international

authors： Sobrio F,Debruyne D,Dhilly M,Chazalviel L,Camsonne R,Kakiuchi T,Tsukada H,Barré L

更新日期：2005-05-01 00:00:00

abstract：:Diabetic neuropathy (DN) is a common form of peripheral neuropathy, yet the mechanisms responsible for chronic pain in this disease are poorly understood. The up-regulation of the expression and function of voltage-gated sodium channel Nav1.7 has been implicated in DN, however, the exact mechanism is unclear. In the p...

journal_title：Neurochemistry international

authors： Huang Y,Zang Y,Zhou L,Gui W,Liu X,Zhong Y

更新日期：2014-09-01 00:00:00

abstract：:A noticeable loss of cardiolipin, a significant accumulation of fluorescent products of lipid peroxidation and an increased ability to produce reactive oxygen species in vitro are characteristics of aged rat brain mitochondria, as has been demonstrated in this study. In contrast mitochondrial electron transport chain ...

journal_title：Neurochemistry international

authors： Sen T,Sen N,Jana S,Khan FH,Chatterjee U,Chakrabarti S

更新日期：2007-04-01 00:00:00

abstract：:Ischemic neuronal injury is associated with several life- and vision-threatening diseases. Neuroprotection is essential in the treatment of these diseases. Here, we identified and characterized a novel peptide, FK18, from basic fibroblast growth factor (bFGF). We further assessed the neuroprotective effects of this pe...

journal_title：Neurochemistry international

authors： Xiong S,Xu Y,Ma M,Wang H,Wei F,Gu Q,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Synaptic degeneration is one of the earliest hallmarks of Alzheimer disease (AD) and results in loss of cognitive function. One of the causative agents for the synaptic degeneration is the amyloid β-peptide (Aβ), which is formed from its precursor protein by two sequential cleavages mediated by β- and γ-secretase. We ...

journal_title：Neurochemistry international

authors： Frykman S,Teranishi Y,Hur JY,Sandebring A,Yamamoto NG,Ancarcrona M,Nishimura T,Winblad B,Bogdanovic N,Schedin-Weiss S,Kihara T,Tjernberg LO

更新日期：2012-07-01 00:00:00

abstract：:The distribution of substance P in the colon of piebald lethal (s(1)/s(1)) mice was studied by radioimmunoassay and immunohistochemistry. These animals inherit as a Mendelian recessive trait an aganglionic distal colon. In the region proximal to the aganglionic segment, there is an extensive transitional or hypogangli...

journal_title：Neurochemistry international

authors： Bu'lock AJ,Vaillant C,Dockray GJ

更新日期：1984-01-01 00:00:00

abstract：:The amyloid beta-peptide (AbetaP) is the major protein component of brain senile plaques in Alzheimer's disease. The redox state of methionine-35 residue plays a critical role in peptide neurotoxic actions. We used the fragment 31-35 of AbetaP [AbetaP(31-35)], containing a single methionine-35 residue (Met-35), to inv...

journal_title：Neurochemistry international

authors： Misiti F,Clementi ME,Tringali G,Vairano M,Orsini F,Pezzotti M,Navarra P,Giardina B,Pozzoli G

更新日期：2006-10-01 00:00:00

abstract：:The cardiovascular and pulmonary responses to vasoactive intestinal contractor (VIC) were compared with those of endothelin (ET)-1, ET-2, ET-3 and sarafotoxin 6b (S6b) and the mechanism by which ET-1 alters vascular resistance was investigated in the hindquarters vascular bed of the cat. In a manner similar to ET-1 an...

journal_title：Neurochemistry international

authors： Minkes RK,Kadowitz PJ

更新日期：1991-01-01 00:00:00

abstract：:The rat retinal ganglion cell (RGC) line RGC-5 constitutes a widely used model for studying physiological processes in retinal cells. In this paper we investigated the expression of clock and immediately early genes, and calcium mediated responses to physiological stimuli in differentiated and mitotically active RGC-5...

journal_title：Neurochemistry international

authors： Nieto PS,Acosta-Rodríguez VA,Valdez DJ,Guido ME

更新日期：2010-10-01 00:00:00

abstract：:This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

journal_title：Neurochemistry international

authors： Ohmori I,Kobayashi K,Ouchida M

更新日期：2020-12-01 00:00:00

abstract：:There has arisen considerable interest in the study of dopamine D(2/3) agonist binding sites by positron emission tomography (PET), based on the claim that agonist sites represent a functional subset of the total number of sites labeled by more conventional antagonist ligands. To test the basis of this claim, we used ...

journal_title：Neurochemistry international

authors： Minuzzi L,Cumming P

更新日期：2010-05-01 00:00:00

abstract：:This report describes the effects of endothelins (ET-1 and ET-3) on ion transport systems expressed on cultured rat brain capillary endothelial cells (RBEC) and includes investigation of pharmacological properties of ET receptors, their reactivity and induction of signal transduction pathways. ET-1 stimulated IP3 form...

journal_title：Neurochemistry international

authors： Kawai N,Yamamoto T,Yamamoto H,McCarron RM,Spatz M

更新日期：1997-10-01 00:00:00

abstract：:The short-term influences of stress on the activities of tyrosine hydroxylase in vivo and in vitro were examined in mice. The in vivo tyrosine hydroxylase activity was estimated by the rate of dopa accumulation which was measured at 30 min after the injection of NSD-1015 (100 mg kg), an aromatic l-amino acid decarboxy...

journal_title：Neurochemistry international

authors： Oka K,Ashiba G,Kiss B,Nagatsu T

更新日期：1982-01-01 00:00:00