The role of TNF-alpha/NF-kappa B pathway on the up-regulation of voltage-gated sodium channel Nav1.7 in DRG neurons of rats with diabetic neuropathy.

abstract：:Neurosteroids are modulators of several receptors and ion channels and are implicated in the pathophysiology of several neuropsychiatric diseases including hepatic encephalopathy (HE). The neurosteroid, allopregnanolone, a positive allosteric modulator of GABA(A) receptors, accumulates in the brains of HE patients whe...

journal_title：Neurochemistry international

authors： Ahboucha S,Coyne L,Hirakawa R,Butterworth RF,Halliwell RF

更新日期：2006-06-01 00:00:00

abstract：:Protein kinase C (PKC) is involved in several cell events including proliferation, survival and differentiation. The aim of this work was to investigate the role of PKC activation on retinal cells proliferation. We demonstrated that PKC activation by phorbol 12-myristate 13-acetate (PMA), a tumor promoter phorbol este...

journal_title：Neurochemistry international

authors： dos Santos AA,Medina SV,Sholl-Franco A,de Araujo EG

更新日期：2003-01-01 00:00:00

abstract：:The impact of dietary factors on brain health and vulnerability to disease is increasingly appreciated. The results of epidemiological studies, and intervention trials in animal models suggest that diets rich in phytochemicals can enhance neuroplasticity and resistance to neurodegeneration. Here we describe how intera...

journal_title：Neurochemistry international

authors： Murugaiyah V,Mattson MP

更新日期：2015-10-01 00:00:00

abstract：:The transmitter dopamine and the protein acetylcholinesterase are released within the substantia nigra from the dendrites of nigrostriatal neurons. These phenomena do not correspond to the familiar events involved in information transfer at the classic axons synapse. It is possible that both dopamine and acetylcholine...

journal_title：Neurochemistry international

authors： Greenfield SA

更新日期：1985-01-01 00:00:00

abstract：:Neuroinflammation is believed to play an important role in neurological diseases such as Alzheimer's disease (AD). Growing evidence suggests that n-3 PUFA have protective effects by inhibiting inflammatory processes including synthesis of eicosanoids from arachidonic acid. There is also some evidence suggesting that i...

journal_title：Neurochemistry international

authors： Boudrault C,Bazinet RP,Kang JX,Ma DW

更新日期：2010-03-01 00:00:00

abstract：:Ethanol (15% v/v) was administered in the drinking water to male Wistar rats over period of 3 months. Binding properties of muscarinic receptors were studied in synaptosomes from selected brain areas using [(3)H]quinuclidinyl benzilate and its displacement by the selective antagonist, pirenzepine and the agonist, carb...

journal_title：Neurochemistry international

authors： Pietzak ER,Wilce PA,Shanley BC

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

journal_title：Neurochemistry international

authors： Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

更新日期：2019-07-01 00:00:00

abstract：:Many studies indicate that chronic stress and excessive stress hormone can cause an inflammatory response. Thioredoxin-interacting protein (Txnip) as an endogenous thioredoxin inhibitor suppresses thioredoxin-produced antioxidant effects. Txnip was also found to interact with nucleotide-binding oligomerization domain-...

journal_title：Neurochemistry international

authors： Bharti V,Tan H,Zhou H,Wang JF

更新日期：2019-12-01 00:00:00

abstract：:A low density of brain IR2-imidazoline receptive sites has previously been linked to depression. In this study we evaluated brain IR2-binding sites in a rat model of depression, olfactory bulbectomy, and determined the effects of chronic imipramine treatment in vivo on these sites. Compared with sham-operated controls...

journal_title：Neurochemistry international

authors： Zhu H,Paul IA,McNamara M,Redmond A,Nowak G,Piletz JE

更新日期：1997-01-01 00:00:00

abstract：:The effects of a cerebral anti-ischemic drug ifenprodil on the receptor ionophore complex of an N-methyl-D-aspartate (NMDA)-sensitive subclass of central excitatory amino acid receptors were examined using [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10- imine (MK-801) binding in rat brain synaptic memb...

journal_title：Neurochemistry international

authors： Ogita K,Ohkawara A,Suzuki T,Ohgaki T,Uchida S,Meguri H,Yoneda Y

更新日期：1992-07-01 00:00:00

abstract：:Variants in the gene encoding the enzyme glutamic acid decarboxylase like 1 (GADL1) have been associated with response to lithium therapy. Both GADL1 and the related enzyme cysteine sulfinic acid decarboxylase (CSAD) have been proposed to be involved in the pyridoxal-5'-phosphate (PLP)-dependent biosynthesis of taurin...

journal_title：Neurochemistry international

authors： Winge I,Teigen K,Fossbakk A,Mahootchi E,Kleppe R,Sköldberg F,Kämpe O,Haavik J

更新日期：2015-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is linked to several neurological disorders, and neuronal injury cascades initiated by excessive ER stress are mediated, in part, via mitochondrial dysfunction. In the present study, we identified FAM3A as an important regulator of ER stress-induced cell death in neuronal HT22 cells. ...

journal_title：Neurochemistry international

authors： Song Q,Gou WL,Zhang R

更新日期：2016-03-01 00:00:00

abstract：:The system of GABA transporters in neural cells constitutes an efficient mechanism for terminating inhibitory GABAergic neurotransmission. As such these transporter are important therapeutical targets in epilepsy and potentially other neurological diseases related to the GABA system. In this study a number of analogs ...

journal_title：Neurochemistry international

authors： Sarup A,Larsson OM,Bolvig T,Frølund B,Krogsgaard-Larsen P,Schousboe A

更新日期：2003-09-01 00:00:00

abstract：:Local excitation of the hippocampus with N- methyl- d,l -aspartic acid caused a rapid release of specific proteins into the extracellular fluid. The proteins were recovered from the effluent of a small implanted tubing, permeable to macromolecules, and analyzed by sodium dodecyl sulphate electrophoresis. ...

journal_title：Neurochemistry international

authors： Nyström B,Hamberger A,Karlsson JO

更新日期：1986-01-01 00:00:00

abstract：:Posttranslational processing of peptide-precursors is nowadays believed to play an important role in the functioning of neurons and endocrine cells. Both proenkephalins and chromogranins/secretogranins are considered as precursor molecules in these tissues, resulting in posttranslationally formed degradation products ...

journal_title：Neurochemistry international

authors： Dillen L,Miserez B,Claeys M,Aunis D,De Potter W

更新日期：1993-04-01 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor is a subtype of ionotropic glutamate receptor that is involved in synaptic mechanisms of learning and memory, and mediates excitotoxic neuronal injury. In this study, we tested the hypothesis that NMDA receptor subunit gene expression is altered in cortex and hippocampus of OKA...

journal_title：Neurochemistry international

authors： Kamat PK,Rai S,Swarnkar S,Shukla R,Nath C

更新日期：2014-10-01 00:00:00

abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

journal_title：Neurochemistry international

authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

更新日期：1987-01-01 00:00:00

abstract：:We demonstrated that genetically modified fibroblasts can be encapsulated into biocompatible, biodegradable spheres retaining their viability and capacity to continuously secrete nerve growth factor (NGF) for at least two months. Genetically engineered rat fibroblasts producing NGF were encapsulated in an alginate-pol...

journal_title：Neurochemistry international

authors： Maysinger D,Piccardo P,Filipovic-Grcic J,Cuello AC

更新日期：1993-08-01 00:00:00

abstract：:Development of tissue structure and three-dimensional microenvironment is crucial for regeneration of axons in the peripheral nerve repair. In this study we aimed to evaluate the efficacy of nerve regeneration by using an acellular nerve allograft (ANA) injected with allogenic skin-derived precursor differentiated Sch...

journal_title：Neurochemistry international

authors： Wang H,Wu J,Zhang X,Ding L,Zeng Q

更新日期：2016-07-01 00:00:00

abstract：:The effects of hypoxia on the metabolism of the central nervous system were investigated in rats submitted to a low oxygen atmosphere (8% O(2); 92% N(2)). [1-(13)C]glucose and [2-(13)C]acetate were used as substrates, this latter being preferentially metabolized by glial cells. After 1-h substrate infusion, the incorp...

journal_title：Neurochemistry international

authors： Chateil J,Biran M,Thiaudière E,Canioni P,Merle M

更新日期：2001-04-01 00:00:00

abstract：:On the basis of the specific [(3)H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six day...

journal_title：Neurochemistry international

authors： Gulya K,Kása P

更新日期：1984-01-01 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) plays an important role in synaptic plasticity and contributes to several brain functions such as memory, learning, and behaviours. Although a number of studies have demonstrated that various kinds of stimuli such as electrophysiological stimulation, excitotoxic injury, and stre...

journal_title：Neurochemistry international

authors： Horii-Hayashi N,Yoshikawa M,Matsusue Y,Ishizaka S,Nishi M,Wanaka A

更新日期：2011-01-01 00:00:00

abstract：:Esters of dimethylcarbamic acid are known to be poor substrates of acetylcholinesterase. They carbamylate the active catalytic site of the enzyme and the subsequent decarbamylation is a slow but measurable process. Similarly, acetylcholinesterase can be phosphonylated, and the dephosphonylation is extremely slow. Rapi...

journal_title：Neurochemistry international

authors： Dawson RM,Poretski M,Upsher CM

更新日期：1981-01-01 00:00:00

abstract：:One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detec...

journal_title：Neurochemistry international

authors： Ciesielski-Treska J,Ulrich G,Mensch C,Aunis D

更新日期：1984-01-01 00:00:00

abstract：:Amiloride, a potassium sparing diuretic, inhibits adenosine A1 receptor-radioligand binding in calf and rat brain membranes in the low micromolar range. The drug interacted with the A1 receptor in a manner different from classical A1 ligands, but structure-activity relationship studies indicated that this inhibitory e...

journal_title：Neurochemistry international

authors： Garritsen A,Beukers MW,IJzerman AP,Cragoe EJ Jr,Soudijn W

更新日期：1992-02-01 00:00:00

abstract：:The correlation between rotational behaviors and neurochemical changes associated with the striatal damage induced by an unilateral microinjection of kainic acid were investigated. Shortly after the unilateral striatal injection of kainic acid, rats exhibited contralateral rotational behaviors, and these changes were ...

journal_title：Neurochemistry international

authors： Kuriyama K,Kurihara E

更新日期：1982-01-01 00:00:00

abstract：:Autism spectrum disorder is a neurodevelopmental disorder characterized by impaired social interaction, poor communication skills, and repetitive/restrictive behaviors. Elevated blood levels of pro-inflammatory cytokines have been reported in subjects with autism spectrum disorder. On the other hand, early childhood a...

journal_title：Neurochemistry international

authors： Makinodan M,Iwata K,Ikawa D,Yamashita Y,Yamamuro K,Toritsuka M,Kimoto S,Okumura K,Yamauchi T,Yoshino H,Tsujii M,Sugiyama T,Tsuchiya K,Mori N,Matsuzaki H,Kishimoto T

更新日期：2017-03-01 00:00:00

abstract：:Gliotoxin (GT) is a hydrophobic fungal metabolite of the epipolythiodioxopiperazine group which reacts with membrane thiols. When added to a suspension of energized brain mitochondria, it induces matrix swelling of low amplitude, collapse of membrane potential (DeltaPsi), and efflux of endogenous cations such as Ca2+ ...

journal_title：Neurochemistry international

authors： Salvi M,Bozac A,Toninello A

更新日期：2004-10-01 00:00:00

abstract：:TAR DNA-binding protein 43 (TDP-43) is a major pathological protein of ubiquitinated inclusions in motor neurons of sporadic amyotrophic lateral sclerosis (ALS). TDP-43 is ubiquitously expressed and the majority of TDP-43 is normally localized to the nucleus. In motor neurons of patients with ALS, TDP-43 is not locali...

journal_title：Neurochemistry international

authors： Hishizawa M,Yamashita H,Akizuki M,Urushitani M,Takahashi R

更新日期：2019-03-01 00:00:00

abstract：:D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...

journal_title：Neurochemistry international

authors： Orendain-Jaime EN,Ortega-Ibarra JM,López-Pérez SJ

更新日期：2016-11-01 00:00:00