Gliotoxin induces Mg2+ efflux from intact brain mitochondria.

abstract：:The morphological differentiation of normal rat glioblasts induced by glia maturation factor (GMF) was investigated with regard to the reorganization of the cytoskeletal structures by the use of indirect immunofluorescence staining methods. The microfilaments were reorganized from a stress fiber form to a plasmalemmal...

journal_title：Neurochemistry international

authors： Ito J,Kato T,Tanaka R

更新日期：1990-01-01 00:00:00

abstract：:Carotenoids play a pivotal role in prevention of many degenerative diseases mediated by oxidative stress including neurodegenerative diseases like Alzheimer's Disease (AD). The involvement of retinoids in physiology, AD pathology and their therapeutic role in vitro and in vivo has been extensively studied. This review...

journal_title：Neurochemistry international

authors： Obulesu M,Dowlathabad MR,Bramhachari PV

更新日期：2011-10-01 00:00:00

abstract：:The saturable and specific high-affinity uptake of [(3)H]serotonin ([(3)H]5HT) (5 x 10(?8) M) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old C57BL/6N mice. Hippocampal [(3)H]5-HT uptake showed a significant biphasic relationship ...

journal_title：Neurochemistry international

authors： Azmitia E,Brennan MJ,Quartermain D

更新日期：1983-01-01 00:00:00

abstract：:The effect of GM(1) administration upon the time course of the postlesion changes of [(3)H]5hydroxytryptamine uptake in the partially denervated rat hippocampus has been studied 6, 21, 42 and 90 days after surgery. At 6 and 21 days after operation the postlesion decrease of [(3)H]5-hydroxytryptamine uptake was counter...

journal_title：Neurochemistry international

authors： Kiedrowski L,Gra Dkowska M,Oderfeld-Nowak B

更新日期：1987-01-01 00:00:00

abstract：:Taurine-like immunoreactivity (TLI) is found in the pigeon retina at high levels within cones, in select cells of the inner nuclear layer and in sublaminae of the inner plexiform layer. At the ultrastructural level a high density of immuno-gold particles in visualized in the ellipsoid, but not in the paraboloid area o...

journal_title：Neurochemistry international

authors： Ueck M,Hach A,Verdone-Smith C,Lake N

更新日期：1995-12-01 00:00:00

abstract：:Phosphodiesterase-5 (PDE5) inhibitors act by competing with the substrate, cGMP, for the catalytic site of the enzyme. Two commercialized PDE5 inhibitors, sildenafil and vardenafil, are being used to treat erectile dysfunction. These two compounds differ in the heterocyclic ring system used to mimic the purine ring of...

journal_title：Neurochemistry international

authors： Corbin JD,Beasley A,Blount MA,Francis SH

更新日期：2004-11-01 00:00:00

abstract：:The neuromodulator adenosine, has been shown to have the highest density of central uptake sites in the nucleus tractus solitarius in the dorsal brain stem. The nucleus tractus solitarius is involved in the central regulation of reflex cardiovascular activity suggesting that adenosine may also be involved in central c...

journal_title：Neurochemistry international

authors： Lawrence AJ,Castillo-Meléndez M,Jarrott B

更新日期：1994-09-01 00:00:00

abstract：:Amyloid deposition within the brains of Alzheimer's Disease patients results in the activation of microglial cells and the induction of a local inflammatory response. The interaction of microglia or monocytes with beta-amyloid (A beta) fibrils elicits the activation a complex tyrosine kinase-based signal transduction ...

journal_title：Neurochemistry international

authors： Combs CK,Bates P,Karlo JC,Landreth GE

更新日期：2001-11-01 00:00:00

abstract：:Glial (GLT-1 and GLAST) and neuronal (EAAC1) high-affinity transporters mediate the sodium dependent glutamate reuptake in mammalian brain. Their dysfunction leads to neuronal damage by allowing glutamate to remain in the synaptic cleft for a longer duration. The purpose of the present study is to understand their con...

journal_title：Neurochemistry international

authors： Raghavendra Rao VL,Rao AM,Dogan A,Bowen KK,Hatcher J,Rothstein JD,Dempsey RJ

更新日期：2000-05-01 00:00:00

abstract：:Recent studies have suggested that neurosteroids such as pregnenolone, progesterone (PG) and their derivatives, have a role in activating autophagy in addition to diverse other functions. In our previous studies, we demonstrated that cellular free Zn(2+) is involved in oxidative stress-induced autophagy and autophagic...

journal_title：Neurochemistry international

authors： Kim HN,Lee SJ,Koh JY

更新日期：2012-01-01 00:00:00

abstract：:Glutathione (GSH) is an essential component of intracellular antioxidant systems that plays a primordial role in the protection of cells against oxidative stress, maintaining redox homeostasis and xenobiotic detoxification. GSH synthesis in the brain is limited by the availability of cysteine and glutamate. Cystine, t...

journal_title：Neurochemistry international

authors： Garza-Lombó C,Petrosyan P,Tapia-Rodríguez M,Valdovinos-Flores C,Gonsebatt ME

更新日期：2018-12-01 00:00:00

abstract：:The Xenopus oocyte expression and recording system has allowed a detailed analysis of the physiology and pharmacology of neuronal ion channels including their sensitivity to ethanol. It is important however, to ascertain the effects of a particular drug on the channels inherently expressed by oocytes to ensure that dr...

journal_title：Neurochemistry international

authors： Clayton R,Woodward JJ

更新日期：2000-01-01 00:00:00

abstract：:Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

journal_title：Neurochemistry international

authors： Romei C,Raiteri L

更新日期：2016-10-01 00:00:00

abstract：:Considerable evidence has been accumulated to suggests that blocking the inflammatory reaction promotes neuroprotection and shows therapeutic potential for clinical treatment of ischemic brain injury. Consequently, anti-inflammatory therapies are being explored for prevention and treatment of these diseases. Induction...

journal_title：Neurochemistry international

authors： Simão F,Matté A,Pagnussat AS,Netto CA,Salbego CG

更新日期：2012-10-01 00:00:00

abstract：:Lycopene is a potent free radicals scavenger with demonstrated protective efficacy in several experimental models of oxidative damage. Trimethyltin (TMT) is an organotin compound with neurotoxic effects on the hippocampus and other limbic structures and is used to model neurodegenerative diseases targeting these brain...

journal_title：Neurochemistry international

authors： Qu M,Zhou Z,Chen C,Li M,Pei L,Chu F,Yang J,Wang Y,Li L,Liu C,Zhang L,Zhang G,Yu Z,Wang D

更新日期：2011-12-01 00:00:00

abstract：:Intrauterine growth retardation induced by ligation of the uterine vessels in pregnant rats on the 5th day before delivery was associated with brain and body weights of hypotrophic offspring significantly lower than those of pair-aged control rats, even after 6 weeks of postnatal rearing under normal conditions. In vi...

journal_title：Neurochemistry international

authors： Chanez C,Flexor MA,Hamon M

更新日期：1985-01-01 00:00:00

abstract：:Aquaporin-4 (AQP4) is a key molecule for maintaining water and ion homeostasis associated with neuronal activity in the central nervous system, but the roles of AQP4 in adult neurogenesis remain largely unexplored. Based on preliminary evidences over the past years, AQP4 appears to emerge as an important player regula...

journal_title：Neurochemistry international

authors： Zheng GQ,Li Y,Gu Y,Chen XM,Zhou Y,Zhao SZ,Shen J

更新日期：2010-04-01 00:00:00

abstract：:Concanavalin A-binding glycoprotein with 250 K M(r) found in the postsynaptic density (PSD)-enriched preparation (or synaptic cytoskeleton) from rat cerebellum was identified with P400 protein from the physicochemical properties and enrichment in the cerebellum. Proteins homologous to the cerebellar 250 K M(r) protein...

journal_title：Neurochemistry international

authors： Suzuki T,Abe-Dohmae S,Tanaka R

更新日期：1992-01-01 00:00:00

abstract：:Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-reso...

journal_title：Neurochemistry international

authors： Sakai S,Shichita T

更新日期：2019-11-01 00:00:00

abstract：:Manganese (Mn) is a widely distributed trace element that is essential for normal brain function and development. However, chronic exposure to excessive Mn has been known to lead to neuronal loss and manganism, a disease with debilitating motor and cognitive deficits, whose clinical syndrome resembling idiopathic Park...

journal_title：Neurochemistry international

authors： Liu X,Yang J,Lu C,Jiang S,Nie X,Han J,Yin L,Jiang J

更新日期：2017-09-01 00:00:00

abstract：:Epilepsy is a neurological disease recognized as the consequence of excessive neuronal excitability. Endocannabinoid system, the critical regulator of synaptic inhibition in brain, was supposed to be closely involved in epilepsy. Cannabinoid receptors mostly locate on presynaptic terminals of both excitatory and inhib...

journal_title：Neurochemistry international

authors： Xue B,Zhang X,Wang Y

更新日期：2020-12-01 00:00:00

abstract：:Glial scar is a major impediment to axonal regeneration in central nervous system (CNS) disorders. Overcoming this physical and biochemical barrier might be crucial for axonal regeneration and functional compensation during the progression of CNS disorders. The mammalian target of rapamycin (mTOR) is an evolutionarily...

journal_title：Neurochemistry international

authors： Li CY,Li X,Liu SF,Qu WS,Wang W,Tian DS

更新日期：2015-04-01 00:00:00

abstract：:The effect of aging and CDP-choline treatment (20 mg kg⁻¹ body weight i.p. for 28 days) on the maximal rates (V(max)) of representative mitochondrial enzyme activities related to Krebs' cycle (citrate synthase, α-ketoglutarate dehydrogenase, malate dehydrogenase), glutamate and related amino acid metabolism (glutamate...

journal_title：Neurochemistry international

authors： Villa RF,Ferrari F,Gorini A

更新日期：2012-12-01 00:00:00

abstract：:Pregnenolone sulfate (PREGS) has been shown, either at high nanomolar or at micromolar concentrations, to increase neuronal activity by inhibiting GABAergic and by stimulating glutamatergic neurotransmission. PREGS is also a potent modulator of sigma type 1 (sigma1) receptors. It has been proposed that these actions o...

journal_title：Neurochemistry international

authors： Schumacher M,Liere P,Akwa Y,Rajkowski K,Griffiths W,Bodin K,Sjövall J,Baulieu EE

更新日期：2008-03-01 00:00:00

abstract：:Previously, we revealed that the state of the actin cytoskeleton affects the uptake activity of the serotonin transporter (SERT). Recently, it was reported that the C-terminus of SERT interacts with MacMARCKS, a substrate of PKC that can bind to the actin cytoskeleton. To elucidate the importance of the C-terminal reg...

journal_title：Neurochemistry international

authors： Mochizuki H,Amano T,Seki T,Matsubayashi H,Mitsuhata C,Morita K,Kitayama S,Dohi T,Mishima HK,Sakai N

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The major hallmark of Alzheimer's disease (AD) is the formation of amyloid aggregates, which are formed due to improper folding of proteins leading to the aggregation of amyloid beta (Aβ) 42 peptide. Inhibition of Aβ 42 aggregation using a drug such as carbenoxolone (Cbx), which has already been stated as ne...

journal_title：Neurochemistry international

authors： Sharma S,Nehru B,Saini A

更新日期：2017-09-01 00:00:00

abstract：:Oxidative stress-induced neuronal death due to hydrogen peroxide overload plays a critical role in the pathogenesis of numerous neurological diseases. Insulin-like growth factor-1 (IGF-1) is important in maintaining neuronal survival, proliferation, and differentiation in the central nervous system. We now report that...

journal_title：Neurochemistry international

authors： Zhong J,Lee WH

更新日期：2007-11-01 00:00:00

abstract：:Ghrelin, a 28 amino acid brain-gut peptide, has attracted increasing attention for its neuroprotective effect in Parkinson's disease (PD). In view of the pivotal role of excitability of dopaminergic neurons in substantia nigra pars compacta (SNc) in the function of nigrostriatal system, it is of great significance to ...

journal_title：Neurochemistry international

authors： Chang X,Ma Z,Shi L,Xie J

更新日期：2020-09-01 00:00:00

abstract：:Gastrointestinal peptides and hormones are known to penetrate through the utero-placental barrier and regulate fetal development. In the present study, we tested permeation of maternal brain-derived neurotrophic factor (BDNF) to fetuses, using BDNF-gene deficient mice and exogenous BDNF administration. At embryonic da...

journal_title：Neurochemistry international

authors： Kodomari I,Wada E,Nakamura S,Wada K

更新日期：2009-02-01 00:00:00

abstract：:The iron siderophore binding protein lipocalin 2 (LCN2, also known as 24p3, NGAL and siderocalin) may be involved in iron homeostasis, but to date, little is known about expression of its putative receptor, brain-type organic cation transporter (BOCT, also known as BOCT1, 24p3R, NGALR and LCN2R), in the brain during n...

journal_title：Neurochemistry international

authors： Chia WJ,Tan FC,Ong WY,Dawe GS

更新日期：2015-08-01 00:00:00