Abnormal glycosylation of myelin-associated glycoprotein in quaking mouse brain.

abstract：:We demonstrate the feasibility and usefulness of the histoblot immunostaining of cryosections of whole hemispheres of healthy and Alzheimer diseased (AD) human brains by localizing a neuron-specific marker, the anti-neuronal nuclei (NeuN) antigen. As expected, cortical NeuN-immunopositive regions were generally thinne...

journal_title：Neurochemistry international

authors： Beliczai Z,Varszegi S,Gulyas B,Halldin C,Kasa P,Gulya K

更新日期：2008-12-01 00:00:00

abstract：:Various populations of bovine adrenal chromaffin cells were isolated first by successive digestions with collagenase (original cell preparation) followed by sedimentation through a stepwise bovine serum albumin gradient (cell layers I, II and III). At the fine structural level, the ratios between the number of adrenal...

journal_title：Neurochemistry international

authors： Lemaire S,Dumont M,Mercier P,Lemaire I,Calvert R

更新日期：1983-01-01 00:00:00

abstract：:Ischemic neuronal injury is associated with several life- and vision-threatening diseases. Neuroprotection is essential in the treatment of these diseases. Here, we identified and characterized a novel peptide, FK18, from basic fibroblast growth factor (bFGF). We further assessed the neuroprotective effects of this pe...

journal_title：Neurochemistry international

authors： Xiong S,Xu Y,Ma M,Wang H,Wei F,Gu Q,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Even though the inducing effect of electromagnetic fields (EMF) on the neural differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) is a distinctive, the underlying mechanism of differentiation remains unclear. To find out the signaling pathways involved in the neural differentiation of BM-MSCs by EMF...

journal_title：Neurochemistry international

authors： Park JE,Seo YK,Yoon HH,Kim CW,Park JK,Jeon S

更新日期：2013-03-01 00:00:00

abstract：:The oligosaccharide chains attached to the multiple forms of acetylcholinesterase (AChE) in a fraction enriched in membranes of the sarcoplasmic reticulum and T-tubules of rabbit skeletal muscle were studied using lectins. By sequential extraction of the membranes with Triton X-100, two preparations of soluble enzyme ...

journal_title：Neurochemistry international

authors： Cánovas-Muñoz MD,Vidal CJ

更新日期：1990-01-01 00:00:00

abstract：:Using specific antibodies to met-enkephalin, met-enkephalin-Arg(6)-Phe(7) and met-enkephalin-Arg(6)-Gly(7)-Leu(8), we have studied the distribution of these opioid peptides in the frog adrenal gland by means of the indirect immunofluorescence technique. Bright staining of all chromaffin cells was observed by applicati...

journal_title：Neurochemistry international

authors： Leboulenger F,Cupo A,Castanas E,Benyamina M,Pelletier G,Vaudry H

更新日期：1986-01-01 00:00:00

abstract：:In this study, the role of exogenous fatty acids in the regulation of proteolipid protein (PLP) gene expression was investigated using the following model culture system: C6 glioma cells expressing the green-fluorescent protein (eGFP) driven by different segments of PLP promoter. Eicosapentanoic acid (EPA; 20:5 n-3), ...

journal_title：Neurochemistry international

authors： Salvati S,Natali F,Attorri L,Raggi C,Di Biase A,Sanchez M

更新日期：2004-04-01 00:00:00

abstract：:The effects of N-methyl-norsalsolinol on basal and inhibited activity of monoamine oxidase (MAO) in membrane preparations from the caudate nucleus of the rat have been studied. For the first time, the physiological step of dopamine oxidation to 3, 4 dihydroxyphenylacetic aldehyde (DPAA) was examined. N-methyl-norsalso...

journal_title：Neurochemistry international

authors： Moser A,Scholz J,Bamberg H,Böhme V

更新日期：1996-01-01 00:00:00

abstract：:The amyloid precursor protein (APP) and presenilin-1 (PS-1) are not only of importance for the normal functioning of the various neurons, but also play central roles in the pathogenesis of Alzheimer's disease (AD). Through the use of immunohistochemical and Western blot techniques, the bidirectional axonal transport o...

journal_title：Neurochemistry international

authors： Papp H,Pakaski M,Kasa P

更新日期：2002-12-01 00:00:00

abstract：:We have previously reported that, unlike their rat counterparts, the survival of mouse cerebellar granule cells is independent of chronic stimulation whether owing to elevated K(+)-induced depolarization or NMDA (N-methyl-D-aspartate) receptor activation. One explanation could be that during the critical period mouse ...

journal_title：Neurochemistry international

authors： Mogensen HS,Jørgensen OS

更新日期：1996-11-01 00:00:00

abstract：:The less active form of human tyrosine hydroxylase has been previously reported but its physiological role is unknown. We partially purified the less active form of tyrosine hydroxylase from human adrenals, and examined differences in the properties of the active and less active forms. We succeeded in activation of th...

journal_title：Neurochemistry international

authors： Ishii A,Kiuchi K,Matsuyama M,Satake T,Nagatsu T

更新日期：1990-01-01 00:00:00

abstract：:This study evaluated the effects of a novel, pH-sensitive surfactant, dodecyl 2-(1'-imidazolyl) propionate (DIP), on cationic lipid mediated transfection in primary rat brain neuronal and glial cultures. The cationic lipid complex DOTAP/DOPE (1, 2-dioleoyl-3-trimethylammonium propionate and dioleoyl phosphatidylethano...

journal_title：Neurochemistry international

authors： Wang S,Bui V,Hughes JA,King MA,Meyer EM

更新日期：2000-07-01 00:00:00

abstract：:Primary cultures of cerebral cortical astrocytes and neurons, as well as neurons growing on top of the astrocytes (sandwich co-cultures), were incubated with 1-[13C]glucose or 2-[13C]acetate and in the presence or absence of the glutamine synthetase inhibitor methionine sulfoximine. [13C]NMR spectroscopy at 125 MHz wa...

journal_title：Neurochemistry international

authors： Sonnewald U,Westergaard N,Schousboe A,Svendsen JS,Unsgård G,Petersen SB

更新日期：1993-01-01 00:00:00

abstract：:We tested the ability of the non-competitive N-methyl-D-aspartate (NMDA) antagonist, dizocilpine (MK-801), to promote protection against the acute effect of 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatal slices. Pretreatment with MK-801 at concentrations higher than 15 microM partially prevented the dopamine (...

journal_title：Neurochemistry international

authors： Venero JL,Santiago M,Machado A,Cano J

更新日期：1996-10-01 00:00:00

abstract：:On the basis of the specific [(3)H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six day...

journal_title：Neurochemistry international

authors： Gulya K,Kása P

更新日期：1984-01-01 00:00:00

abstract：:Biochemical abnormalities have been implicated in possible mechanisms underlying the epileptic phenomena. Some of these alterations include changes in the activity of several enzymes present in epileptic tissues. Systemic administration of pilocarpine in rats induces electrographic and behavioral limbic seizures and s...

journal_title：Neurochemistry international

authors： Fernandes MJ,Naffah-Mazzacoratti MG,Cavalheiro EA

更新日期：1996-05-01 00:00:00

abstract：:There is substantial evidence that hyperammonemia is one of the main factors contributing to the neurological alterations found in hepatic encephalopathy. The mechanisms by which chronic moderate hyperammonemia affects brain function involves alterations in neurotransmission at different steps. This article reviews th...

journal_title：Neurochemistry international

authors： Corbalán R,Hernández-Viadel M,Llansola M,Montoliu C,Felipo V

更新日期：2002-08-01 00:00:00

abstract：:NMDA receptors are essential for neurotransmission and key mediators of synaptic signaling, but they can also trigger deleterious degenerative processes that lead to cell death. Growing evidence suggests that selective blockade of the heterogeneous subunits that comprise the NMDA receptor may enable better control of ...

journal_title：Neurochemistry international

authors： Choo AM,Geddes-Klein DM,Hockenberry A,Scarsella D,Mesfin MN,Singh P,Patel TP,Meaney DF

更新日期：2012-04-01 00:00:00

abstract：:The use of synthetic antisense oligonucleotides as specific inhibitors of gene expression exploits the susceptibility of mRNA to functional blockade at several levels, including mRNA processing, transport, translation and degradation. It is becoming increasingly apparent that the actions of these synthetic oligomers a...

journal_title：Neurochemistry international

authors： Knee R,Murphy PR

更新日期：1997-09-01 00:00:00

abstract：:The effects of cholesterol oxides on regular and neuronal PC12 cells were examined. Among the cholesterol oxides tested, 7-beta-, 22(R)- and 25-OH-cholesterol were very toxic to regular PC12 cells such that approximately 80% of cells were killed after a 3 day incubation with 20 micrograms/ml (50 microM) of these agent...

journal_title：Neurochemistry international

authors： Chang JY,Liu LZ

更新日期：1997-10-01 00:00:00

abstract：:Insulin receptors from rat brain regions were studied for insulin binding and receptor associated kinase activity, in alloxan induced short-term and long-term diabetes, and insulin induced hypoglycemia. Insulin receptor activity was assessed by [125I]insulin binding, and basal as well as insulin stimulated kinase acti...

journal_title：Neurochemistry international

authors： Gupta G,Azam M,Baquer NZ

更新日期：1992-06-01 00:00:00

abstract：:This study aimed to examine the effects of Cacna1a mutation on the phenotype of Scn1a-associated epilepsy in rats. We used rats with an N1417H missense mutation in the Scn1a gene and others with an M251K mutation in the Cacna1a gene. Scn1a/Cacna1a double mutant rats were generated by mating both Scn1a and Cacna1a muta...

journal_title：Neurochemistry international

authors： Ohmori I,Kobayashi K,Ouchida M

更新日期：2020-12-01 00:00:00

abstract：:While studies with [(3)H]D-aspartate ([(3)H]d-Asp) illustrate specific interactions with excitatory amino acid transporters (EAATs), new insights into the pharmacological characteristics and localization of specific EAAT subtypes depend upon the availability of novel ligands. One such ligand is [(3)H]-(2S,4R)-4-methyl...

journal_title：Neurochemistry international

authors： Apricò K,Beart PM,Crawford D,O'shea RD

更新日期：2007-12-01 00:00:00

abstract：:Minocycline is neuroprotective in animal models of a number of acute CNS injuries, neurodegenerative diseases and CNS infection. While anti-inflammatory and anti-apoptotic effects of Minocycline have been characterized, the molecular basis for the neuroprotective effects of Minocycline remains unclear. We report here ...

journal_title：Neurochemistry international

authors： Mishra MK,Ghosh D,Duseja R,Basu A

更新日期：2009-06-01 00:00:00

abstract：:High-affinity binding sites for tritiated hemicholinium-3, a potent and selective inhibitor of the sodium-dependent high-affinity choline transport, have been found in synaptosomal membranes from insect ganglia. The binding of hemicholinium to ganglionic membrane preparations was saturable and specific with an apparen...

journal_title：Neurochemistry international

authors： Knipper M,Krieger J,Breer H

更新日期：1989-01-01 00:00:00

abstract：:Taurine is found at millimolar concentration in the retina and retinal pigment epithelium. High concentrations of taurine are essential for maintenance of retinal function. Taurine uptake by retina and retinal pigment epithelium was significantly enhanced by physiological concentrations of insulin as well as by high g...

journal_title：Neurochemistry international

authors： Salceda R

更新日期：1999-10-01 00:00:00

abstract：:Neurosteroids are modulators of several receptors and ion channels and are implicated in the pathophysiology of several neuropsychiatric diseases including hepatic encephalopathy (HE). The neurosteroid, allopregnanolone, a positive allosteric modulator of GABA(A) receptors, accumulates in the brains of HE patients whe...

journal_title：Neurochemistry international

authors： Ahboucha S,Coyne L,Hirakawa R,Butterworth RF,Halliwell RF

更新日期：2006-06-01 00:00:00

abstract：:With their potent regenerative and protective capacities, stem cell-derived conditioned media emerged as an effective alternative to cell therapy, and have a prospect to be manufactured as pharmaceutical products for tissue regeneration applications. Our study investigates the neuroregenerative potential of human dent...

journal_title：Neurochemistry international

authors： Chouaib B,Collart-Dutilleul PY,Blanc-Sylvestre N,Younes R,Gergely C,Raoul C,Scamps F,Cuisinier F,Romieu O

更新日期：2021-01-16 00:00:00

abstract：:Although the mechanism of electroconvulsive therapy (ECT) is not clearly known, its effects on hormones have been widely studied. However, there are controversies about the effect of ECT on blood glucose level. In addition, the possible effects of ECT on the blood cholesterol, LDL, HDL, and triglyceride levels are ign...

journal_title：Neurochemistry international

authors： Ghanizadeh A,Issaee M,Sigaroody MO,Kaviani K

更新日期：2012-12-01 00:00:00

abstract：:Although ischemic preconditioning (IP) can provide powerful protection on brain against ischemic insult, it is rarely used in clinic to prevent the occurrence of ischemic stroke because of safety concerns. It is therefore necessary to seek the safer stimuli to initiate pharmacological preconditioning. Our previous wor...

journal_title：Neurochemistry international

authors： Wu X,Zhou C,Du F,Lu Y,Peng B,Chen L,Zhu L

更新日期：2013-01-01 00:00:00