Immunohistochemical and biochemical evidence for the presence of the pentapeptide met-enkephalin and the heptapeptide met-enkephalin-Arg(6)-Phe(7) but not the octapeptide met-enkephalin-Arg(6)-Gly(7)-Leu(8) in amphibian chromaffin cells.

abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Rupture of lysosome is a major cellular stress condition leading to cell death in PD. We have previously shown that environmenta...

journal_title：Neurochemistry international

authors： Dong H,Qin Y,Huang Y,Ji D,Wu F

更新日期：2019-06-01 00:00:00

abstract：:Cerebellar granule neurons produce homogenous cultures that provide a unique opportunity for quantifying the apoptosis by propidium iodide- and deoxynucleotidyl transferase-flow cytometry combined analysis and for studying its regulation by neurotrophins. Nerve growth factor (NGF) was found to promote postmitotic surv...

journal_title：Neurochemistry international

authors： Muller Y,Tangre K,Clos J

更新日期：1997-08-01 00:00:00

abstract：:The presence of acetylcholinesterase (AChE) mRNA and activity in the tissues and cells involved in immune responses prompted us to investigate the level and pattern of AChE components in spleen. AChE activity was higher in mouse spleen (0.46 +/- 0.13 micromol of acetylthiocholine split per hour and per mg protein) tha...

journal_title：Neurochemistry international

authors： Nieto-Cerón S,Moral-Naranjo MT,Muñoz-Delgado E,Vidal CJ,Campoy FJ

更新日期：2004-07-01 00:00:00

abstract：:It is well established that histaminergic neurons in the posterior hypothalamus make connections with whole brain areas and regulate several functions. Recent evidence indicates that histaminergic neurons are heterogeneous cell group and organized into distinct circuits. However, functional circuits of histaminergic n...

journal_title：Neurochemistry international

authors： Umehara H,Mizuguchi H,Fukui H

更新日期：2012-11-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

journal_title：Neurochemistry international

authors： Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

更新日期：2019-10-01 00:00:00

abstract：:Human atrial natriuretic peptide (Ser 99-Tyr 126) was rapidly degraded by both choroid plexus and hypothalamic membranes with a complex pattern of cleavage. The use of protease inhibitors allowed a preliminary characterization of the enzymes involved in the hydrolysis of the Ser-Phe and Phe-Arg bonds of iodine-labelle...

journal_title：Neurochemistry international

authors： Deschodt-Lanckman M,Vanneste Y,Michaux F

更新日期：1988-01-01 00:00:00

abstract：:Some biochemical and histological studies of Parkinson's disease patients' brains and 6-OHDA-lesioned rats suggest that dopaminergic dennervation of the striatum leads to the nitrergic system hypofunction in this structure. Hence, recently the modulation of nitric oxide (NO)- soluble guanylyl cyclase-cyclic GMP signal...

journal_title：Neurochemistry international

authors： Lorenc-Koci E,Czarnecka A,Lenda T,Kamińska K,Konieczny J

更新日期：2013-12-01 00:00:00

abstract：:In chicks submitted to light stimulation, the synthesis of gangliosides of the retina ganglion cell increases with respect to chicks maintained in the dark. In an attempt to elucidate if the activation of glycosyltransferases participates in the establishment of these light-dark differences detected in vivo, we examin...

journal_title：Neurochemistry international

authors： Bussolino DF,Guido ME,Caputto BL

更新日期：1997-07-01 00:00:00

abstract：:The ultrastructural localization of AChE and BuChE was studied in motor endplates of the rat and mouse diaphragms, using the CNS(?) modification of the one-step Cu-thiocholine procedure. AChE activity was observed on pre- and postsynaptic membranes, in the basal lamina and in the Schwann cell-nerve terminal interspace...

journal_title：Neurochemistry international

authors： Brzin M,Sketelj J,Grubi Z,Kiauta T

更新日期：1980-01-01 00:00:00

abstract：:Recent studies have suggested that neurosteroids such as pregnenolone, progesterone (PG) and their derivatives, have a role in activating autophagy in addition to diverse other functions. In our previous studies, we demonstrated that cellular free Zn(2+) is involved in oxidative stress-induced autophagy and autophagic...

journal_title：Neurochemistry international

authors： Kim HN,Lee SJ,Koh JY

更新日期：2012-01-01 00:00:00

abstract：:Increased neurosteroids with allosteric modulatory activity on GABA(A) receptors such as 3α-5α tertrahydroprogesterone; allopregnanolone (ALLO), are candidates to explain the phenomenon of "increased GABAergic tone" in hepatic encephalopathy (HE). However, it is not known how changes of other GABA(A) receptor modulato...

journal_title：Neurochemistry international

authors： Ahboucha S,Talani G,Fanutza T,Sanna E,Biggio G,Gamrani H,Butterworth RF

更新日期：2012-07-01 00:00:00

abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

journal_title：Neurochemistry international

authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

更新日期：1987-01-01 00:00:00

abstract：:A single molecular species of GTP-binding protein (G protein) has been purified from the bovine cerebral cortex. The immunoblot analysis indicated that the isolated G protein might be Gi1 or Gi2 but not Go, since it was reacted by specific antibodies, anti-Gi alpha 1-2 and anti-Gi alpha 1-1, but not anti-Go alpha. Whe...

journal_title：Neurochemistry international

authors： Nishikawa M,Hirouchi M,Kuriyama K

更新日期：1997-07-01 00:00:00

abstract：:Mitochondria play a pivotal role in the regulation of energy metabolism and apoptotic pathways. Properties and functions of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to a different extent to cellular stress and degeneration. We have investigated the effect of 3-nitro...

journal_title：Neurochemistry international

authors： Singh S,Misiak M,Beyer C,Arnold S

更新日期：2010-10-01 00:00:00

abstract：:Neuroserpin, the major inhibitor of tissue plasminogen activator (tPA) in brain, has been shown to be up-regulated in Alzheimer's disease (AD). Inhibition of tPA activity leads to reduced brain levels of plasmin, one of the main enzymes responsible for the degradation and clearance of amyloid-beta and its plaques from...

journal_title：Neurochemistry international

authors： Subhadra B,Schaller K,Seeds NW

更新日期：2013-11-01 00:00:00

abstract：:Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

journal_title：Neurochemistry international

authors： Storch A,Ludolph AC,Schwarz J

更新日期：1999-11-01 00:00:00

abstract：:The consequences of irreversibly-inhibiting D2 dopaminergic receptors on the expression of D1 and D2 dopamine receptor mRNAs and proenkephalin mRNA and on the levels of mu- and delta-opioid receptors in rat striatum were studied following single or repeated administration of the irreversibly-acting D2 dopamine recepto...

journal_title：Neurochemistry international

authors： Chen JF,Aloyo VJ,Qin ZH,Weiss B

更新日期：1994-10-01 00:00:00

abstract：:This study aimed to elucidate locomotor activity changes in 6-hydroxydopamine (6-OHDA) induced Parkinson's disease (PD) and investigate the possible beneficial effects of melatonin on altered levels of locomotor activity, cyclooxygenase (COX), prostaglandin E2 (PGE2), nuclear factor kappa-B (NF-κB), nitrate/nitrite an...

journal_title：Neurochemistry international

authors： Yildirim FB,Ozsoy O,Tanriover G,Kaya Y,Ogut E,Gemici B,Dilmac S,Ozkan A,Agar A,Aslan M

更新日期：2014-12-01 00:00:00

abstract：:Transglutaminase (TGase) activity is increased in affected regions of brains from patients with Huntington's disease (HD). TGase activity is particularly elevated in the nucleus compared with the cytoplasm from these brains. Gamma-glutaminyl-lysyl cross-links have been detected in nuclear inclusions in HD brain, indic...

journal_title：Neurochemistry international

authors： Karpuj MV,Becher MW,Steinman L

更新日期：2002-01-01 00:00:00

abstract：:Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

journal_title：Neurochemistry international

authors： Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

更新日期：2020-10-01 00:00:00

abstract：:Catalpol has been shown to rescue neurons from kinds of damage in vitro and in vivo in previous reports. However, the effect of catalpol on the nitric oxide (NO) system via MAPKs signaling pathway of mesencephalic neurons largely remains to be verified. The current study examined that whether catalpol modulated NO and...

journal_title：Neurochemistry international

authors： Bi J,Jiang B,Hao S,Zhang A,Dong Y,Jiang T,An L

更新日期：2009-03-01 00:00:00

abstract：:Monosialoganglioside (GM1) is a glycosphingolipid present in most cell membranes that displays antioxidant and neuroprotective properties. It has been recently described that GM1 induces vasodilation. However, the mechanisms underlying GM1-induced vasodilation were not evaluated to date. Therefore, in this study we in...

journal_title：Neurochemistry international

authors： Furian AF,Oliveira MS,Magni DV,Souza MA,Bortoluzzi VT,Bueno LM,Royes LF,Mello CF

更新日期：2008-12-01 00:00:00

abstract：:The distribution of substance P in the colon of piebald lethal (s(1)/s(1)) mice was studied by radioimmunoassay and immunohistochemistry. These animals inherit as a Mendelian recessive trait an aganglionic distal colon. In the region proximal to the aganglionic segment, there is an extensive transitional or hypogangli...

journal_title：Neurochemistry international

authors： Bu'lock AJ,Vaillant C,Dockray GJ

更新日期：1984-01-01 00:00:00

abstract：:The effects of membrane lipid disturbances induced by ischemia and exogenously added lipids on the uptake of GABA and Ca(2+) were investigated in gerbil brain synaptosomes. Ischemia was produced by bilateral ligation of common carotid arteries in Mongolian gerbil for 10 min. The level of the free fatty acids (FFA) inc...

journal_title：Neurochemistry international

authors： Noremberg K,Strosznajder J

更新日期：1986-01-01 00:00:00

abstract：:Lycopene is a potent free radicals scavenger with demonstrated protective efficacy in several experimental models of oxidative damage. Trimethyltin (TMT) is an organotin compound with neurotoxic effects on the hippocampus and other limbic structures and is used to model neurodegenerative diseases targeting these brain...

journal_title：Neurochemistry international

authors： Qu M,Zhou Z,Chen C,Li M,Pei L,Chu F,Yang J,Wang Y,Li L,Liu C,Zhang L,Zhang G,Yu Z,Wang D

更新日期：2011-12-01 00:00:00

abstract：:The relationship between acidosis and the metabolism of glutamine and glutamate was studied in cultured astrocytes. Acidification of the incubation medium was associated with an increased formation of aspartate from glutamate and glutamine. The rise of the intracellular content of aspartate was accompanied by a signif...

journal_title：Neurochemistry international

authors： Yudkoff M,Daikhin Y,Nissim I,Nissim I

更新日期：2000-04-01 00:00:00

abstract：:The ventral pallidum (VP) is a critical component of the basal ganglia neurocircuitry regulating learning and decision making; however, its precise role in controlling associative learning of environmental stimuli conditioned to appetitive or aversive outcomes is still unclear. Here, we investigated the expression of ...

journal_title：Neurochemistry international

authors： Macpherson T,Mizoguchi H,Yamanaka A,Hikida T

更新日期：2019-06-01 00:00:00

abstract：:Maple syrup urine disease (MSUD) is an inherited neurometabolic disorder biochemically characterized by the accumulation of the branched-chain alpha-keto acids (BCKA) alpha-ketoisocaproic (KIC), alpha-keto-beta-methylvaleric (KMV) and alpha-ketoisovaleric (KIV) and their respective branched-chain alpha-amino acids in ...

journal_title：Neurochemistry international

authors： Funchal C,Latini A,Jacques-Silva MC,Dos Santos AQ,Buzin L,Gottfried C,Wajner M,Pessoa-Pureur R

更新日期：2006-12-01 00:00:00

abstract：:Mecamylamine is a well-described non specific antagonist of nicotinic acetylcholine receptors (nAChRs), used in therapy and in psychopharmacological studies. [(11)C]-Mecamylamine was prepared and evaluated as a putative radioligand for positron emission tomography to study nicotinic acetylcholine receptors. The radios...

journal_title：Neurochemistry international

authors： Sobrio F,Debruyne D,Dhilly M,Chazalviel L,Camsonne R,Kakiuchi T,Tsukada H,Barré L

更新日期：2005-05-01 00:00:00

abstract：:We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performa...

journal_title：Neurochemistry international

authors： Lista S,Toschi N,Baldacci F,Zetterberg H,Blennow K,Kilimann I,Teipel SJ,Cavedo E,Dos Santos AM,Epelbaum S,Lamari F,Dubois B,Floris R,Garaci F,Hampel H,Alzheimer Precision Medicine Initiative (APMI).

更新日期：2017-09-01 00:00:00