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Diagnostic accuracy of CSF neurofilament light chain protein in the biomarker-guided classification system for Alzheimer's disease.

Abstract：

:We assessed the diagnostic accuracy of cerebrospinal fluid (CSF) neurofilament light chain (NFL) protein in the classification of patients with Alzheimer's disease (AD) and cognitively healthy control individuals (HCs) and patients with frontotemporal dementia (FTD) as comparisons. Particularly, we tested the performance of CSF NFL concentration in differentiating patient groups stratified by fluid biomarker profiles, independently of the severity of cognitive impairment (mild cognitive impairment (MCI) and AD dementia individuals), using a biomarker-guided descriptive classification system for AD. CSF NFL concentrations were examined in a multicenter cross-sectional study of 108 participants stratified in AD pathophysiology-negative (both CSF tau and the 42-amino acid-long amyloid-beta (Aβ) peptide (Aβ1-42)) (n = 15), tau pathology-positive only (n = 15), Aβ pathology-positive only (n = 13), AD pathophysiology-positive (n = 33), FTD (n = 9) patients, and HCs (n = 23), according to the biomarker-based classification system. The performance of CSF NFL in discriminating AD pathophysiology-positive patients from HCs is fair, whereas the ability in differentiating tau-positive patients from HCs is poor. The classificatory performance in distinguishing AD pathophysiology-positive patients from FTD is unsatisfactory.

journal_name

Neurochem Int

journal_title

Neurochemistry international

authors

Lista S,Toschi N,Baldacci F,Zetterberg H,Blennow K,Kilimann I,Teipel SJ,Cavedo E,Dos Santos AM,Epelbaum S,Lamari F,Dubois B,Floris R,Garaci F,Hampel H,Alzheimer Precision Medicine Initiative (APMI).

doi

10.1016/j.neuint.2017.05.010

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

355-360

eissn

0197-0186

issn

1872-9754

pii

S0197-0186(16)30478-8

journal_volume

108

pub_type

杂志文章,多中心研究

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