Quercetin promotes cell apoptosis and inhibits the expression of MMP-9 and fibronectin via the AKT and ERK signalling pathways in human glioma cells.


:Gliomas are the most common and malignant primary brain tumours and are associated with a poor prognosis despite the availability of multiple therapeutic options. Quercetin, a traditional Chinese medicinal herb, is an important flavonoid and has anti-cancer activity. Here, we evaluated whether quercetin could inhibit glioma cell viability and migration and promote apoptosis. The treatment of U87-MG glioblastoma and U251 and SHG44 glioma cell lines with different concentrations of quercetin inhibited cell viability in a dose-dependent manner. Wound healing assays indicated that quercetin significantly decreased glioma cell migration. β-galactosidase staining, DNA staining and Annexin V-EGF/PI double staining assays demonstrated that quercetin promoted cell senescence and apoptosis. In addition, the protein levels of p-AKT, p-ERK, Bcl-2, matrix metallopeptidase 9 (MMP-9) and fibronectin (FN) were significantly reduced following quercetin treatment. Therefore, we conclude that quercetin might inhibit the viability and migration and promote the senescence and apoptosis of glioma cells by suppressing the Ras/MAPK/ERK and PI3K/AKT signalling pathways. Quercetin might be a potential candidate for the clinical treatment of glioma.


Neurochem Int


Pan HC,Jiang Q,Yu Y,Mei JP,Cui YK,Zhao WJ




Has Abstract


2015-01-01 00:00:00












  • Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is the most common form of dementia, accounting for 60-70% of cases in subjects over 65 years of age. Several postulates have been put forward that relate AD neuropathology to intellectual and functional impairment. These range from free-radical-induced damage, through cholinergic dysfunction,...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Hynd MR,Scott HL,Dodd PR

    更新日期:2004-10-01 00:00:00

  • The role of neutrophils in mediating stroke injury in the diabetic db/db mouse brain following hypoxia-ischemia.

    abstract::Diabetic mice exhibit increased mortality and morbidity following stroke. Recent studies from our laboratory have indicated that increased morbidity in diabetic db/db mice relative to their non-diabetic db/+ littermates is associated with increased levels of MMP-9 protease activity, increased blood-brain barrier (BBB)...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Kumari R,Bettermann K,Willing L,Sinha K,Simpson IA

    更新日期:2020-10-01 00:00:00

  • RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: a model system to study PMP70 function.

    abstract::The function of PMP70, one of the four ABC half-transporters of mammalian peroxisomes, encoded by ABCD3 gene, is still unclear. The finding that PMP70 over-expression partially corrected very long-chain fatty acid oxidation defects in fibroblasts of X-linked adrenoleukodystrophy patients, has unveiled its potential cl...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Di Benedetto R,Denti MA,Salvati S,Sanchez M,Attorri L,David G,Di Biase A

    更新日期:2008-05-01 00:00:00

  • Modifiable risk factors promoting neurodegeneration is associated with two novel brain degradation markers measured in serum.

    abstract::There has been limited success with blood-based biomarkers of neurodegeneration. One perceived reason is that blood has no direct contact to the brain. Recently developed blood-based biomarkers of tau-degradation have shown promise as potential tools for peripheral assessment of neurodegeneration; however, factors con...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Neergaard JS,Dragsbæk K,Christiansen C,Nielsen HB,Workman CT,Brix S,Henriksen K,Karsdal MA

    更新日期:2017-09-01 00:00:00

  • Extrasynaptic GABAA receptors in the crosshairs of hormones and ethanol.

    abstract::Gamma-aminobutyric acid (GABA) is the main chemical inhibitory neurotransmitter in the brain. In the central nervous system (CNS) it acts on two distinct types of receptor: an ion channel, i.e., an "ionotropic" receptor permeable to Cl- and HCO3- (GABAA receptors) and a G-protein coupled "metabotropic" receptor that i...

    journal_title:Neurochemistry international

    pub_type: 杂志文章,评审


    authors: Mody I

    更新日期:2008-01-01 00:00:00

  • Impaired neuronal and astroglial metabolic activity in chronic unpredictable mild stress model of depression: Reversal of behavioral and metabolic deficit with lanicemine.

    abstract::Major depressive disorder is the leading cause of disability and suicidality worldwide. Here, we evaluated neural metabolic activity in prefrontal cortex (PFC) in C57BL6 mice undergoing a chronic unpredictable mild stress (CUMS) for three weeks to induce depression. Further, the efficacy of Lanicemine, a low trapping ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Mishra PK,Adusumilli M,Deolal P,Mason GF,Kumar A,Patel AB

    更新日期:2020-07-01 00:00:00

  • N-methylisoquinolinium ion as an inhibitor of tyrosine hydroxylase, aromatic l-amino acid decarboxylase and monoamine oxidase.

    abstract::The effect of the N-methylisoquinolinium ion (NMIQ(+)) on the activity of enzymes related to metabolism of dopamine was studied using a rat clonal pheochromocytoma PC12h cell line. The activities of tyrosine hydroxylase (TH), aromatic l-amino acid decarboxylase (AADC) and monoamine oxidase (MAO) were inhibited by NMIQ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Naoi M,Takahashi T,Parvez H,Kabeya R,Taguchi E,Yamaguchi K,Hirata Y,Minami M,Nagatsu T

    更新日期:1989-01-01 00:00:00

  • Neuroprotective role of taurine on MK-801-induced memory impairment and hyperlocomotion in zebrafish.

    abstract::Schizophrenia is a neuropsychiatric condition that reaches around 1% of people worldwide. Because taurine exerts a neuroprotective role in the brain, this molecule is a promising candidate to reduce schizophrenia-like symptoms. Here, we investigated a possible neuroprotective role of taurine against MK-801-induced mem...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Franscescon F,Müller TE,Bertoncello KT,Rosemberg DB

    更新日期:2020-05-01 00:00:00

  • Hemicholinum-3 binding sites in the nervous tissue of insects.

    abstract::High-affinity binding sites for tritiated hemicholinium-3, a potent and selective inhibitor of the sodium-dependent high-affinity choline transport, have been found in synaptosomal membranes from insect ganglia. The binding of hemicholinium to ganglionic membrane preparations was saturable and specific with an apparen...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Knipper M,Krieger J,Breer H

    更新日期:1989-01-01 00:00:00

  • The disk membrane as model for an excitable membrane.

    abstract::Excitable membranes appear to be biochemically characterized by the presence of a highly specific receptor protein, which undergoes conformational changes upon stimulation and returns to its original conformation for renewed excitability. Our present knowledge of the disk membrane and its receptor protein rhodopsin is...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Daemen FJ,de Grip WJ

    更新日期:1980-01-01 00:00:00

  • Biochemical and behavioral effects of long-term citalopram administration and discontinuation in rats: role of serotonin synthesis.

    abstract::We have investigated effects of continuous SSRI administration and abrupt discontinuation on biochemical and behavioral indices of rat brain serotonin function, and attempted to identify underlying mechanisms. Biochemistry of serotonin was assessed with brain tissue assays and microdialysis; behavior was assessed as t...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Bosker FJ,Tanke MA,Jongsma ME,Cremers TI,Jagtman E,Pietersen CY,van der Hart MG,Gladkevich AV,Kema IP,Westerink BH,Korf J,den Boer JA

    更新日期:2010-12-01 00:00:00

  • Ionic requirements for transport and release of [(3)H]GABA by synaptic plasma membrane vesicles.

    abstract::A simple procedure for isolating a fraction enriched in synaptic plasma membrane (SPM) vesicles from sheep brain cortex is described and is used in studying uptake and release of [(3)H]GABA. The crude synaptosomal fraction was subjected to osmotic shock and the lysate was subfractioned in a discontinuous density gradi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Gonçalves PP,Santos MS,Carvalho AP

    更新日期:1990-01-01 00:00:00

  • HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism.

    abstract::Selective dopaminergic neurotoxicity induced by 1-methyl-4-phenylpyridine (MPP+) is believed to be due to the transmembrane uptake by the dopamine transporter and subsequent inhibition of mitochondrial complex I and/or production of free radicals. However, little is known about the molecular sequence of intracellular ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Storch A,Ludolph AC,Schwarz J

    更新日期:1999-11-01 00:00:00

  • Topographic associations between DNA fragmentation and Alzheimer's disease neuropathology in the hippocampus.

    abstract::To identify whether the process of apoptosis bears a topographic relationship to selected aspects of Alzheimer's disease (AD) pathology, we used an in situ nick translation method (TUNEL) to map DNA fragmentation in hippocampal sections immunostained for abnormally phosphorylated tau, which exists in the neurofibrilla...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Sugaya K,Reeves M,McKinney M

    更新日期:1997-08-01 00:00:00

  • Release of acid-soluble radioactivity from rapidly transported proteins in homogenates of rabbit superior colliculus.

    abstract::An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Gustavsson S,Karlsson JO

    更新日期:1985-01-01 00:00:00

  • Sildenafil treatment of vascular dementia in aged rats.

    abstract:BACKGROUND:and purpose: In this study, we employed a multiple microinfarction (MMI) based vascular dementia (VaD) model in aged rats and tested the therapeutic effects of Sildenafil, a phosphodiesterase type 5 inhibitor, on cognitive decline, white matter damage, autophagy and inflammatory response associated with VaD....

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Venkat P,Chopp M,Zacharek A,Cui C,Landschoot-Ward J,Qian Y,Chen Z,Chen J

    更新日期:2019-07-01 00:00:00

  • Adult development of the hippocampal-serotonin system of C57BL/6N mice; analysis of high-affinity uptake of (3)H-5HT in slices and synaptosomes.

    abstract::The saturable and specific high-affinity uptake of [(3)H]serotonin ([(3)H]5HT) (5 x 10(?8) M) was studied in slices from the hippocampus, parietal cortex, septum-preoptic area, and hypothalamus of male 2, 6, 12 and 24-32 month old C57BL/6N mice. Hippocampal [(3)H]5-HT uptake showed a significant biphasic relationship ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Azmitia E,Brennan MJ,Quartermain D

    更新日期:1983-01-01 00:00:00

  • Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder.

    abstract::Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

    更新日期:2008-05-01 00:00:00

  • Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body.

    abstract::The carotid bodies (CBs) are chemosensory organs that respond to hypoxemia with transmitter neurosecretion, leading to a respiratory reflex response. It has been proposed that acetylcholine is a key regulator of transmitter release through activation of presynaptic nicotinic acetylcholine receptors (nAChRs). In the pr...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Meza RC,Ortiz FC,Bravo E,Iturriaga-Vásquez P,Eugenín JL,Varas R

    更新日期:2012-01-01 00:00:00

  • Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.

    abstract::Long-term potentiation (LTP) is a well-established experimental model used to investigate the synaptic basis of learning and memory. LTP at mossy fibre - CA3 synapses in the hippocampus is unusual because it is normally N-methyl-d-aspartate (NMDA) receptor-independent. Instead it seems that the trigger for mossy fibre...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Sherwood JL,Amici M,Dargan SL,Culley GR,Fitzjohn SM,Jane DE,Collingridge GL,Lodge D,Bortolotto ZA

    更新日期:2012-09-01 00:00:00

  • Glycoprotein synthesis and postsynaptic remodelling in long-term memory.

    abstract::This paper describes the background in experiment and theory on which present-day studies of the biochemistry of learning and memory are based. It then reviews specifically the use of passive avoidance training in the day-old chick as a model for the analysis of the cellular events associated with memory-formation. It...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Rose SP

    更新日期:1989-01-01 00:00:00

  • Ammonium induced dysfunction of 5-HT2B receptor in astrocytes.

    abstract::Previously we reported that gene expression of astrocytic 5-HT2B receptors was decreased in brains of depressed animals exposed to chronic mild stress (CMS) (Li et al., 2012) and of Parkinson's disease (Song et al., 2018). Depression is also one of the psychiatric symptoms in hyperammonemia, and astrocyte is a primary...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Yue T,Li B,Gu L,Huang J,Verkhratsky A,Peng L

    更新日期:2019-10-01 00:00:00

  • Effect of calmodulin antagonists on phospholipase D activity in SH-SY5Y cells.

    abstract::The aim of this study was to investigate the involvement of calmodulin in phospholipase D activation in SH-SY5Y cells. Cells prelabelled with [3H]-palmitic acid were incubated with calmodulin antagonists and/or other compounds. Phosphatidylethanol, a specific marker for phospholipase D activity, and phosphatidic acid ...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: del Carmen Boyano-Adánez M,Gustavsson L

    更新日期:2002-03-01 00:00:00

  • Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA.

    abstract::Some biochemical and histological studies of Parkinson's disease patients' brains and 6-OHDA-lesioned rats suggest that dopaminergic dennervation of the striatum leads to the nitrergic system hypofunction in this structure. Hence, recently the modulation of nitric oxide (NO)- soluble guanylyl cyclase-cyclic GMP signal...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Lorenc-Koci E,Czarnecka A,Lenda T,Kamińska K,Konieczny J

    更新日期:2013-12-01 00:00:00

  • Inhibitory effects of lithium ion on intracellular Ca2+ mobilization in the rat hippocampal slices.

    abstract::Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

    更新日期:1995-03-01 00:00:00

  • Inhibition of evoked neurotransmitter release from rat hippocampus by a polypeptide toxin isolated from the marine snail Conus distans.

    abstract::The active fraction, isolated and partially purified from the crude venom of the marine snail Conus distans, with a molecular mass of about 25 kDa, inhibits neurotransmitter release in rat hippocampus. This toxin (distans Toxin) inhibits the electrically evoked tritium labelled noradrenaline release from rat hippocamp...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Saxena VK,Partoens P,de Block J,Coen EP,Vauquelin G,De Potter WP

    更新日期:1992-01-01 00:00:00

  • Long-term changes in noradrenaline (NA) and dopamine (DA) contents of rat cerebellum following neonatal X-irradiation.

    abstract::The effects of neonatal X-irradiation on cerebellar cathecholamine levels in rats were studied at different postnatal intervals. Since synaptogenesis in the cerebellar cortex is basically a postnatal phenomenon, changes in noradrenaline (NA) and dopamine (DA) levels induced by X-rays on the cerebella (CE) of adult rat...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Dopico AM,Zieher LM,Mayo J,Altschüller N,López JJ,Jaim-Etcheverry G

    更新日期:1989-01-01 00:00:00

  • Modulation of choline acetyltransferase synthesis by okadaic acid, a phosphatase inhibitor, and KN-62, a CaM kinase inhibitor, in NS-20Y neuroblastoma.

    abstract::Choline-O-acetyltransferase (ChAT) is the enzyme which catalyses the biosynthesis of the neurotransmitter acetylcholine in cholinergic neurons. Here we show that in mouse cholinergic NS-20Y neuroblastoma cells cultured in the presence of either okadaic acid (serine/threonine phosphatases 1 and 2A inhibitor) or KN-62 (...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Pahud G,Bontron S,Eder-Colli L

    更新日期:2001-01-01 00:00:00

  • The adenosine A2A receptor antagonist SCH58261 reduces macrophage/microglia activation and protects against experimental autoimmune encephalomyelitis in mice.

    abstract::Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) affecting more than 2.5 million individuals worldwide. In the present study, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) mice were treated with adenosine recept...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Chen Y,Zhang ZX,Zheng LP,Wang L,Liu YF,Yin WY,Chen YY,Wang XS,Hou ST,Chen JF,Zheng RY

    更新日期:2019-10-01 00:00:00

  • Tetrahydrocurcumin epigenetically mitigates mitochondrial dysfunction in brain vasculature during ischemic stroke.

    abstract::The objectives of this study are to identify the mechanism of mitochondrial dysfunction during cerebral ischemic/reperfusion (I/R) injury and the therapeutic potential of tetrahydrocurcumin (THC) to mitigate mitochondrial dysfunction in experimental stroke model. In our study, 8-10 weeks old male C57BL/6 wild-type mic...

    journal_title:Neurochemistry international

    pub_type: 杂志文章


    authors: Mondal NK,Behera J,Kelly KE,George AK,Tyagi PK,Tyagi N

    更新日期:2019-01-01 00:00:00