P400 protein is one of the major substrates for Ca2+/calmodulin-dependent protein kinase II in the postsynaptic density-enriched fraction isolated from rat cerebral cortex, hippocampus and cerebellum.

abstract：:Phosphodiesterase-5 (PDE5) inhibitors act by competing with the substrate, cGMP, for the catalytic site of the enzyme. Two commercialized PDE5 inhibitors, sildenafil and vardenafil, are being used to treat erectile dysfunction. These two compounds differ in the heterocyclic ring system used to mimic the purine ring of...

journal_title：Neurochemistry international

authors： Corbin JD,Beasley A,Blount MA,Francis SH

更新日期：2004-11-01 00:00:00

abstract：:Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

journal_title：Neurochemistry international

authors： Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

更新日期：1995-03-01 00:00:00

abstract：:The short-term influences of stress on the activities of tyrosine hydroxylase in vivo and in vitro were examined in mice. The in vivo tyrosine hydroxylase activity was estimated by the rate of dopa accumulation which was measured at 30 min after the injection of NSD-1015 (100 mg kg), an aromatic l-amino acid decarboxy...

journal_title：Neurochemistry international

authors： Oka K,Ashiba G,Kiss B,Nagatsu T

更新日期：1982-01-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

journal_title：Neurochemistry international

authors： Berman ER,Segal N,Schneider A,Feeney L

更新日期：1980-01-01 00:00:00

abstract：:Increased concentrations of kynurenine pathway metabolites have been reported by several groups for disorders involving psychosis, including schizophrenia and bipolar disorder. To identify components of the pathway that may be relevant as biomarkers or may underlie the etiology of psychosis, it is essential to charact...

journal_title：Neurochemistry international

authors： Miller CL,Llenos IC,Cwik M,Walkup J,Weis S

更新日期：2008-05-01 00:00:00

abstract：:The present study was designed to investigate the turnover rates of D1 dopamine receptors in the brain and retina of adult and aged rats. To this aim, we monitored the increase in the density of 3H-SCH 23390 binding sites after the administration of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2 dihydroquin...

journal_title：Neurochemistry international

authors： Giorgi O,Pibiri MG,Dal Toso R,Toffano G,Biggio G

更新日期：1992-03-01 00:00:00

abstract：:Brain edema and the subsequent increase in intracranial pressure are the major neurological complications in fulminant hepatic failure (FHF). Brain edema in FHF is predominantly "cytotoxic" due principally to astrocyte swelling. It is generally believed that ammonia plays a key role in this process, although the mecha...

journal_title：Neurochemistry international

authors： Jayakumar AR,Rao KV,Murthy ChR,Norenberg MD

更新日期：2006-05-01 00:00:00

abstract：:It is well established that histaminergic neurons in the posterior hypothalamus make connections with whole brain areas and regulate several functions. Recent evidence indicates that histaminergic neurons are heterogeneous cell group and organized into distinct circuits. However, functional circuits of histaminergic n...

journal_title：Neurochemistry international

authors： Umehara H,Mizuguchi H,Fukui H

更新日期：2012-11-01 00:00:00

abstract：:D1 and D2 receptors are key mediators of dopaminergic signaling in the brain, and since the manifestations of pathologies related to dopamine are different in female and male patients, it is important to analyze if there are sex-related differences in dopaminergic markers. To contribute to the knowledge in this regard...

journal_title：Neurochemistry international

authors： Orendain-Jaime EN,Ortega-Ibarra JM,López-Pérez SJ

更新日期：2016-11-01 00:00:00

abstract：:Alteration in the lysosomal system (LS) may represent a central mechanism in neurodegeneration. 6-Hydroxydopamine (6-OHDA) induces oxidative stress and cell death in catecholaminergic cells. The LS and caspases participate in apoptosis, although the mechanism(s) that is involved is not completely understood. Here, we ...

journal_title：Neurochemistry international

authors： Lee DC,Womble TA,Mason CW,Jackson IM,Lamango NS,Severs WB,Palm DE

更新日期：2007-03-01 00:00:00

abstract：:Glutamine has multiple physiological and pathophysiological roles in the brain. Because of their position at the interface between blood and brain, the cerebral capillaries and the choroid plexuses that form the blood-brain barriers (BBB) and blood-cerebrospinal fluid (CSF) barriers, have the potential to influence br...

journal_title：Neurochemistry international

authors： Xiang J,Ennis SR,Abdelkarim GE,Fujisawa M,Kawai N,Keep RF

更新日期：2003-09-01 00:00:00

abstract：:Five glutamate transporter genes have been identified; two of these (EAAT3 and EAAT4) are expressed in neurons and are predominantly confined to the membranes of cell bodies and dendrites. At an ultrastructural level, glutamate transporters have been shown to surround excitatory synapses in hippocampus and cerebellum ...

journal_title：Neurochemistry international

authors： Otis TS,Brasnjo G,Dzubay JA,Pratap M

更新日期：2004-09-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:A simple, rapid and sensitive method for the detection of acetylcholine and choline in tissue extracts is reported. Acetylcholine and choline are first separated by HPLC then react in a mini-column with acetylcholinesterase and choline oxidase immobilized on Sepharose. The resulting H(2)O(2) produced by choline oxidas...

journal_title：Neurochemistry international

authors： Stadler H,Nesselhut T

更新日期：1986-01-01 00:00:00

abstract：:Ischemic neuronal injury is associated with several life- and vision-threatening diseases. Neuroprotection is essential in the treatment of these diseases. Here, we identified and characterized a novel peptide, FK18, from basic fibroblast growth factor (bFGF). We further assessed the neuroprotective effects of this pe...

journal_title：Neurochemistry international

authors： Xiong S,Xu Y,Ma M,Wang H,Wei F,Gu Q,Xu X

更新日期：2017-09-01 00:00:00

abstract：:Striatal quinolinic acid lesions have been used as a model for the pathology seen in Huntington's disease. Seven days following a unilateral injection of 100 nmol of quinolinic acid into the rat caudate-putamen (striatum), a large increase in the binding of [3H]WIN 35,428 to the lesioned caudate-putamen was seen when ...

journal_title：Neurochemistry international

authors： Gehlert DR,Schoepp DD

更新日期：1992-12-01 00:00:00

abstract：:Electroacupuncture has been shown to induce a preconditioning effect in the brain. The mechanisms for this protection are not fully elucidated. We hypothesize that this protection is mediated by excitatory amino acid transporters (EAATs) that have been shown to be neuroprotective. To test this hypothesis, two-month ol...

journal_title：Neurochemistry international

authors： Zhu X,Yin J,Li L,Ma L,Tan H,Deng J,Chen S,Zuo Z

更新日期：2013-10-01 00:00:00

abstract：:Microglial activation has been implicated in neurodegenerative diseases. Therefore, inhibition of inflammation mediated by microglia is a strategy in neurodegenerative disease therapy. In this study, we isolated cryptotanshinone and 15,16-dihydrotanshinone I from Salvia miltiorrhiza, a traditional Korean herb medicine...

journal_title：Neurochemistry international

authors： Lee P,Hur J,Lee J,Kim J,Jeong J,Kang I,Kim SY,Kim H

更新日期：2006-01-01 00:00:00

abstract：:To clarify molecular mechanism for sustained activation of gamma protein kinase C (gammaPKC), a neuron-specific subtype, we investigated the involvement of phospholipase A2 (PLA2) products in the membrane association of gammaPKC upon activation of G protein coupled purinoceptors in CHO-K1 and NG 108-15 cells. In addit...

journal_title：Neurochemistry international

authors： Yagi K,Shirai Y,Hirai M,Sakai N,Saito N

更新日期：2004-07-01 00:00:00

abstract：:GABAA receptors mediate most of the fast inhibitory transmissions in the central nervous system. These receptors are pentameric complexes that exhibit high structural and pharmacological heterogeneity, as they can be constructed from 19 distinct subunits. GABAA receptors are the targets of numerous clinically relevant...

journal_title：Neurochemistry international

authors： Gravielle MC

更新日期：2018-09-01 00:00:00

abstract：:Alzheimer's disease (AD) is a common neurodegenerative disorders, in which oxidative stress plays an important role. The present study investigated the effect of eicosapentaenoic acid-enriched phospholipids (EPA-enriched PL) from the sea cucumber Cucumaria frondosa on oxidative injury in PC12 cells induced by hydrogen...

journal_title：Neurochemistry international

authors： Wu FJ,Xue Y,Liu XF,Xue CH,Wang JF,Du L,Takahashi K,Wang YM

更新日期：2014-01-01 00:00:00

abstract：:Depression is characterized by sadness, purposelessness, irritability, and impaired body functions. Depression causes severe symptoms for several weeks, and dysthymia, which may cause chronic, low-grade symptoms. Treatment of depression involves psychotherapy, medications, or phototherapy. Clinical and experimental ev...

journal_title：Neurochemistry international

authors： Shabbir F,Patel A,Mattison C,Bose S,Krishnamohan R,Sweeney E,Sandhu S,Nel W,Rais A,Sandhu R,Ngu N,Sharma S

更新日期：2013-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder and is characterized by pathological aggregates of amyloid β-protein (Aβ) and tau protein. On the basis of genetic evidence, biochemical data, and animal models, Aβ has been suggested to be responsible for the pathogenesis of AD (the am...

journal_title：Neurochemistry international

authors： Ono K

更新日期：2018-10-01 00:00:00

abstract：:One- and two-dimensional electrophoresis patterns and distribution of major cytoskeletal proteins were studied in primary astrocytes with either flat-epitheloid or stellate appearance. No major differences in the electrophoretic patterns of actin, tubulin, glial fibrillary acidic protein (GFAP) and vimentin were detec...

journal_title：Neurochemistry international

authors： Ciesielski-Treska J,Ulrich G,Mensch C,Aunis D

更新日期：1984-01-01 00:00:00

abstract：:Guanidinosuccinate (GSA) and methylguanidine (MG) are endogenous, convulsant guanidino compounds which have been shown to be greatly increased in uremic patients. In the present study, we have investigated the age-related differences in convulsive action and cerebral uptake of these compounds in juvenile mice of 7, 14...

journal_title：Neurochemistry international

authors： D'Hooge R,Pei YQ,Marescau B,De Deyn PP

更新日期：1994-03-01 00:00:00

abstract：:Human induced pluripotent stem cells (hiPSCs) are considered as a powerful tool for drug and chemical screening and development of new in vitro testing strategies in the field of toxicology, including neurotoxicity evaluation. These cells are able to expand and efficiently differentiate into different types of neurona...

journal_title：Neurochemistry international

authors： Zagoura D,Canovas-Jorda D,Pistollato F,Bremer-Hoffmann S,Bal-Price A

更新日期：2017-06-01 00:00:00

abstract：:An intraocular injection of [(3)H]proline was used to label rabbit retinal ganglion cells including components subjected to axonal transport. Degradation of rapidly axonally transported labelled proteins was estimated in an in vitro system using homogenates of the nerve terminal regions. The energy requirements of thi...

journal_title：Neurochemistry international

authors： Gustavsson S,Karlsson JO

更新日期：1985-01-01 00:00:00

abstract：:Spinal muscular atrophy (SMA), the leading genetic cause of infant mortality worldwide, is characterised by the homozygous loss of the survival motor neuron 1 (SMN1) gene. The consequent degeneration of spinal motor neurons and progressive atrophy of voluntary muscle groups results in paralysis and eventually prematur...

journal_title：Neurochemistry international

authors： Farrelly-Rosch A,Lau CL,Patil N,Turner BJ,Shabanpoor F

更新日期：2017-09-01 00:00:00

abstract：:Age, sex, and gonadal hormones have profound effects on ischemic stroke outcomes, although how these factors impact basic stroke pathophysiology remains unclear. There is a plethora of inconsistent data reported throughout the literature, primarily due to differences in the species examined, the timing and methods use...

journal_title：Neurochemistry international

authors： Liu F,McCullough LD

更新日期：2012-12-01 00:00:00