Abstract:
:The present study was designed to investigate the turnover rates of D1 dopamine receptors in the brain and retina of adult and aged rats. To this aim, we monitored the increase in the density of 3H-SCH 23390 binding sites after the administration of the irreversible antagonist N-ethoxycarbonyl-2-ethoxy-1,2 dihydroquinoline (EEDQ). The results indicate that, in aged rats, the production rate of D1 receptors decreases by 41% to 61% in the striatum, nucleus accumbens and substantia nigra, whereas a smaller reduction in the degradation rate of these receptors is observed (-21% to -40%). In contrast, the production rate of D1 receptors in the retina of aged rats remains unchanged, whilst the degradation rate decreases by 25%. These alterations in the rates of receptor production and degradation may account for the age-related decrease in the density of D1 dopamine receptors in the striatum, nucleus accumbens and substantia nigra as well as for the increase in the density of these receptors in the retina of aged rats.
journal_name
Neurochem Intjournal_title
Neurochemistry internationalauthors
Giorgi O,Pibiri MG,Dal Toso R,Toffano G,Biggio Gdoi
10.1016/0197-0186(92)90233-hsubject
Has Abstractpub_date
1992-03-01 00:00:00pages
171S-173Seissn
0197-0186issn
1872-9754journal_volume
20 Supplpub_type
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