BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel.

abstract：:We tested the ability of the non-competitive N-methyl-D-aspartate (NMDA) antagonist, dizocilpine (MK-801), to promote protection against the acute effect of 1-methyl-4-phenylpyridinium ion (MPP+) in rat striatal slices. Pretreatment with MK-801 at concentrations higher than 15 microM partially prevented the dopamine (...

journal_title：Neurochemistry international

authors： Venero JL,Santiago M,Machado A,Cano J

更新日期：1996-10-01 00:00:00

abstract：:Multiple signaling pathways via insulin receptor substrate-1 and -2 play crucial roles in health, diseases, and therapeutics (i.e., longevity, tumorigenesis, and neuroprotection). The 90-kDa heat-shock protein (Hsp90) is an emerging target molecule of therapeutics, Hsp90 inhibitors being promising against various dise...

journal_title：Neurochemistry international

authors： Yoshikawa N,Nemoto T,Satoh S,Maruta T,Yanagita T,Chosa E,Wada A

更新日期：2010-01-01 00:00:00

abstract：:Marked age-related changes are noted in the neurotensin distribution of the human hippocampus. Different neuronal structures containing neurotensin are detected by immunohistochemistry during postnatal brain growth from birth to 4 years but no later. They are the neurotensin-immunoreactive pyramidal cells of the subic...

journal_title：Neurochemistry international

authors： Lotstra F,Mailleux P,Schiffmann SN,Vierendeels G,Vanderhaeghen JJ

更新日期：1989-01-01 00:00:00

abstract：:Taurine is found at millimolar concentration in the retina and retinal pigment epithelium. High concentrations of taurine are essential for maintenance of retinal function. Taurine uptake by retina and retinal pigment epithelium was significantly enhanced by physiological concentrations of insulin as well as by high g...

journal_title：Neurochemistry international

authors： Salceda R

更新日期：1999-10-01 00:00:00

abstract：:A novel copper-containing protein has been isolated in electrophoretically homogeneous state from bovine brain extracts. Some physico-chemical properties of the protein are determined (molecular weight, copper content, isoelectric point, amino acid composition, optical and EPR spectra), and they are compared with thos...

journal_title：Neurochemistry international

authors： Mikaelyan MV,Nalbandyan RM

更新日期：1988-01-01 00:00:00

abstract：:Aminoethylcysteine ketimine is a sulfur-containing cyclic compound produced by the enzymatic alpha-deamination of the parent aminoethylcysteine that has been detected in bovine brain and cerebellum. Aminoethylcysteine ketimine is known to dimerize spontaneously and easily lose one carboxyl group. This decarboxylated c...

journal_title：Neurochemistry international

authors： Matarese RM,Macone A,Crescentini G,Duprè S,Cavallini D

更新日期：1998-04-01 00:00:00

abstract：:Quantitative autoradiography analysis of neurotensin (NT) and somatostatin (SS) binding sites was performed on coronal sections of the medulla oblongata from 2 fetuses, 6 controls and 7 victims of Sudden Infant Death Syndrome (SIDS). Throughout the first postnatal year, mean SS binding site density was similar in cont...

journal_title：Neurochemistry international

authors： Chigr F,Jordan D,Najimi M,Denoroy L,Sarrieau A,de Broca A,Rostene W,Epelbaum J,Kopp N

更新日期：1992-01-01 00:00:00

abstract：:Several metabolic transformations of vitamin A have now been found in the pigment epithelium of cattle retina, leading to the hypothesis that there may be a vitamin A cycle in these cells. A retinol binding protein of MW ? 17,000 in pigment epithelial cytosol has been identified independently in several laboratories. ...

journal_title：Neurochemistry international

authors： Berman ER,Segal N,Schneider A,Feeney L

更新日期：1980-01-01 00:00:00

abstract：:The correlation between rotational behaviors and neurochemical changes associated with the striatal damage induced by an unilateral microinjection of kainic acid were investigated. Shortly after the unilateral striatal injection of kainic acid, rats exhibited contralateral rotational behaviors, and these changes were ...

journal_title：Neurochemistry international

authors： Kuriyama K,Kurihara E

更新日期：1982-01-01 00:00:00

abstract：:Intracellular Ca2+ signals produced by the glutamate receptor agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA; 5 microM) were measured in the somatic and dendritic regions of cerebellar Purkinje neurons in mature cerebellar control cultures (> or = 20 days in vitro) and cultures chronically treated...

journal_title：Neurochemistry international

authors： Netzeband JG,Trotter C,Caguioa JN,Gruol DL

更新日期：1999-08-01 00:00:00

abstract：:Homozygous deletion or mutation in the survival motor neuron (SMN)1 gene causes proximal spinal muscular atrophy (SMA), whereas SMN2 acts as a modifying gene that can influence the severity of SMA. It has been suggested that restoration of the SMN protein level in neuronal cells may prevent cell loss and may be helpfu...

journal_title：Neurochemistry international

authors： Chang HC,Hung WC,Chuang YJ,Jong YJ

更新日期：2004-12-01 00:00:00

abstract：:The integrity of hippocampal G-protein mediated signalling following ibotenate induced lesion of the medial septum was examined. The lesion was confined histologically to the septum and induced a 23% reduction in hippocampal choline acetyltransferase (ChAT) activity and G-proteins levels and related enzyme activities ...

journal_title：Neurochemistry international

authors： McLaughlin M,Inglis FM,Ross BM,Breen KC,McCulloch J

更新日期：1999-07-01 00:00:00

abstract：:Ghrelin, a 28 amino acid brain-gut peptide, has attracted increasing attention for its neuroprotective effect in Parkinson's disease (PD). In view of the pivotal role of excitability of dopaminergic neurons in substantia nigra pars compacta (SNc) in the function of nigrostriatal system, it is of great significance to ...

journal_title：Neurochemistry international

authors： Chang X,Ma Z,Shi L,Xie J

更新日期：2020-09-01 00:00:00

abstract：:Iron accumulation is considered to be involved in the pathogenesis of Parkinson's disease. To demonstrate the relationship between peripheral iron overload and dopaminergic neuron loss in rat substantia nigra (SN), in the present study we used fast cyclic voltammetry, tyrosine hydroxylase (TH) immunohistochemistry, Pe...

journal_title：Neurochemistry international

authors： Jiang H,Song N,Wang J,Ren LY,Xie JX

更新日期：2007-07-01 00:00:00

abstract：:Stroke causes neuronal cell death and destruction of neuronal circuits in the brain and spinal cord. Injury to the brain tissue induces sterile inflammation triggered by the extracellular release of endogenous molecules, but cerebral inflammation after stroke is gradually resolved within several days. In this pro-reso...

journal_title：Neurochemistry international

authors： Sakai S,Shichita T

更新日期：2019-11-01 00:00:00

abstract：:Lithium is well established as a treatment of manic-depressive illness. As for the mechanism of action of lithium, it is proposed that lithium has effects on intracellular calcium ion (Ca2+) movement. But there are few reports in which the effects of lithium on intracellular Ca2+ movement are observed in the mammalian...

journal_title：Neurochemistry international

authors： Okamoto Y,Kagaya A,Motohashi N,Yamawaki S

更新日期：1995-03-01 00:00:00

abstract：:Brain slices from actively myelinating (26-28 days) quaking and normal littermates were dual-labeled with radioactive mannose and fucose for 2 h. Following the incubation myelin was isolated by sucrose density gradient centrifugation and the incorporation of sugars into the major myelinassociated glycoprotein (MAG) de...

journal_title：Neurochemistry international

authors： Konat G,Hogan EL,Leskawa KC,Gantt G,Singh I

更新日期：1987-01-01 00:00:00

abstract：:Intense glucose-based energy metabolism and glutamate synthesis by astrocytes require malate-aspartate-shuttle (MAS) activity to regenerate NAD⁺ from NADH formed during glycolysis, since brain lacks significant glycerophosphate shuttle activity. Aralar is a necessary aspartate/glutamate exchanger for MAS function in b...

journal_title：Neurochemistry international

authors： Li B,Hertz L,Peng L

更新日期：2012-12-01 00:00:00

abstract：:Serotonin2C receptor (5-HT2C) agonists are promising drugs for the treatment of neuropsychiatric diseases. However, their effect is not completely understood in part because they possibly affect several neurobiological networks simultaneously. We studied the effect of the 5-HT2C receptor agonist WAY-163909 (0.3 and 3 ...

journal_title：Neurochemistry international

authors： Chagraoui A,Whitestone S,Baassiri L,Manem J,Di Giovanni G,De Deurwaerdère P

更新日期：2019-03-01 00:00:00

abstract：:Glycine can be substrate for two transporters: GlyT1, largely expressed by astrocytes but also by some non-glycinergic neurons, and GlyT2, most frequently present in glycine-storing nerve endings. In morphological studies, GlyT2 expression had been found to be restricted to caudal regions, being almost undetectable in...

journal_title：Neurochemistry international

authors： Romei C,Raiteri L

更新日期：2016-10-01 00:00:00

abstract：:Platelet-activating factor (PAF), a biologically active lipid (1-O-alkyl-2-acetyl-sn-glycero-3-phosphoholine), is identified in different regions of brain, including hippocampus. Specific PAF-activated receptors (PAFRs) are expressed in corresponding brain areas. PAF has been proposed to be a retrograde messenger of l...

journal_title：Neurochemistry international

authors： Kondratskaya EL,Pankratov YV,Lalo UV,Chatterjee SS,Krishtal OA

更新日期：2004-02-01 00:00:00

abstract：:JM-20 (3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine) is a novel benzodiazepine dihydropyridine hybrid molecule, which has been shown to be a neuroprotective agent in brain disorders involving glutamate receptors. However, the effect of JM-20 on the functionality of the g...

journal_title：Neurochemistry international

authors： Nuñez-Figueredo Y,Pardo Andreu GL,Oliveira Loureiro S,Ganzella M,Ramírez-Sánchez J,Ochoa-Rodríguez E,Verdecia-Reyes Y,Delgado-Hernández R,Souza DO

更新日期：2015-02-01 00:00:00

abstract：:On the basis of abnormal neuropsychological behavior in the open-field test after 2-week zinc deprivation, neurochemical response was examined in young mice fed a zinc-deficient diet for 2 weeks. Serum corticosterone concentration was markedly higher in zinc-deficient mice than in the control mice. Basal signals of in...

journal_title：Neurochemistry international

authors： Takeda A,Yamada K,Tamano H,Fuke S,Kawamura M,Oku N

更新日期：2008-01-01 00:00:00

abstract：:The present study was carried out to clarify whether the imidazolines clonidine, moxonidine and cirazoline as well as the guanidine aganodine inhibit noradrenaline release in the rat and rabbit brain via imidazoline receptors, alpha 2-adrenoceptors and/or histamine H3 receptors. Slices or synaptosomes from the rat or ...

journal_title：Neurochemistry international

authors： Schlicker E,Fink K,Kathmann M,Molderings GJ,Göthert M

更新日期：1997-01-01 00:00:00

abstract：:The mobilization of inositol triphosphate ip3 by N-methyl D-aspartate (NMDA) and kainate, two excitatory amino acid EAA receptor agonists, was studied in cultured chick retina cells as a function of culture differentiation. Kainate (EC50 = 30 microM) stimulated from 6 to 9-fold the production of [3H]ip3 between E8C3 (...

journal_title：Neurochemistry international

authors： Reis RA,Kubrusly RC,de Mello MC,de Mello FG

更新日期：1995-04-01 00:00:00

abstract：:The relationship between acidosis and the metabolism of glutamine and glutamate was studied in cultured astrocytes. Acidification of the incubation medium was associated with an increased formation of aspartate from glutamate and glutamine. The rise of the intracellular content of aspartate was accompanied by a signif...

journal_title：Neurochemistry international

authors： Yudkoff M,Daikhin Y,Nissim I,Nissim I

更新日期：2000-04-01 00:00:00

abstract：:D-aspartate is present in significant concentrations throughout the nervous tissue but its physiological role is still under discussion. Here, we report the process of d-aspartate release in retinal cells. [(3)H]-d-aspartate release occurs through a glutamate/aspartate exchange mechanism using excitatory amino acid tr...

journal_title：Neurochemistry international

authors： Stutz B,Yamasaki EN,de Mello MC,de Mello FG

更新日期：2011-06-01 00:00:00

abstract：:Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic modulator and also as a neuromodulator at the synaptic level. We will present evidence to suggest that these two different modulatory roles are fulfilled by extracellular adenosine originated from different metabolic sources, and involv...

journal_title：Neurochemistry international

authors： Cunha RA

更新日期：2001-02-01 00:00:00

abstract：:A pre-requisite to understanding the physiological mechanisms of action of melatonin is the identification of the target sites where the hormone acts. The radioligand 2-[125I]iodo-melatonin has been used extensively to localize binding sites in both the brain and peripheral tissues. In general these binding sites have...

journal_title：Neurochemistry international

authors： Morgan PJ,Barrett P,Howell HE,Helliwell R

更新日期：1994-02-01 00:00:00

abstract：:Human glutamate dehydrogenase (GDH) gene was fused with a gene fragment encoding the nine amino acid (RKKRRQRRR) protein transduction domain of human immunodeficiency virus TAT protein in bacterial expression vector to produce genetic in-frame TAT-GDH fusion protein. The TAT-GDH protein can enter PC12 cells efficientl...

journal_title：Neurochemistry international

authors： Yoon HY,Lee SH,Cho SW,Lee JE,Yoon CS,Park J,Kim TU,Choi SY

更新日期：2002-07-01 00:00:00